[1]赵　佳,左　林,姜小建,等.动脉粥样硬化患者高同型半胱氨酸血症与胆固醇逆向转运的关系[J].现代检验医学杂志,2019,34(06):47-49.[doi:10.3969 ／ j.issn.1671-7414.2019.06.011]
　ZHAO Jia,ZUO Lin,JIANG Xiao-jian,et al.Relationship between Hyperhomocysteinemia and Reverse Cholesterol Transport in Patients with Atherosclerosis[J].Journal of Modern Laboratory Medicine,2019,34(06):47-49.[doi:10.3969 ／ j.issn.1671-7414.2019.06.011]
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动脉粥样硬化患者高同型半胱氨酸血症与胆固醇逆向转运的关系 ()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第34卷
期数:
2019年06期
页码:
47-49
栏目:
论著
出版日期:
2019-12-30

文章信息/Info

Title:
Relationship between Hyperhomocysteinemia and Reverse Cholesterol Transport in Patients with Atherosclerosis
文章编号:
1671-7414（2019）06-047-04
作者:
赵　佳1; 左　林2; 姜小建1; 姚创利1; 朱建伟1
（1. 西安市中心医院检验科，西安　710003；2. 空军军医大学唐都医院放射科，西安　710038）
Author(s):
ZHAO Jia1;  ZUO Lin2;  JIANG Xiao-jian1;  YAO Chuang-li1;  ZHU Jian-Wei1
（1. Department of Clinical Laboratory, Xi’an Central Hospital, Xi’an 710003, China；2. Department of Radiology, Tangdu Hospital of Air Force Medical University , Xi’an 710038, China）
关键词:
动脉粥样硬化; 高同型半胱氨酸血症; 胆固醇逆向转运; 高密度脂蛋白; 载脂蛋白A Ⅰ; 卵磷脂 胆固醇酰基转移酶
分类号:
R543.5；R446.112
DOI:
10.3969 ／ j.issn.1671-7414.2019.06.011
文献标志码:
A
摘要:
目的　探讨高同型半胱氨酸（high homocysteine, HHcy）对动脉粥样硬化（atherosclerosis, AS）患者血脂和卵 磷脂胆固醇酰基转移酶（lecithin cholesterol acyl transferase, LCAT）的影响。方法　选取2018 年9 月~2019 年6 月诊断 有颈动脉粥样硬化的185 例患者作为研究对象。根据患者是否存在HHcy，分为HHcy 组和对照组。测定同型半胱氨酸 （homocysteine, Hcy）、血脂水平和LCAT 浓度，分析Hcy 水平与血脂水平及LCAT 浓度的相关性。结果　HHcy 组高 密度脂蛋白胆固醇（high density lipoprotein cholesterol, HDL-C）、载脂蛋白A Ⅰ（apolipoprotein A Ⅰ , ApoA Ⅰ）水平 和LACT 浓度显著低于对照组，差异均具有统计学意义（t =2.318，2.405，2.484，均P ＜ 0.05）；HHcy 组Hcy 水平显 著高于对照组，差异具有统计学意义（t =11.266，P ＜ 0.001）。Hcy 水平与HDL-C，ApoA Ⅰ水平和LCAT 浓度均呈负 相关（r = － 0.197，P =0.008；r = － 0.212，P =0.006；r = － 0.221，P =0.005）。结论　HHcy 是AS 的一个独立危险因素。 HHcy 可能通过降低ApoA Ⅰ，HDL 和LCAT 水平，影响它们在胆固醇逆向转运（reverse cholesterol transport, RCT）中 的作用，从而促进AS 的发生与发展。
Abstract:
Objective　To investigate the effect of high homocysteine (HHcy) on blood lipid and lecithin cholesterol acyl transferase (LCAT) in patients with atherosclerosis (AS). Methods　185 cases of patients with carotid artery AS plaque diagnosed by neck doppler ultrasound in the department of neurology of Xi’an Central Hospital from September 2018 to June 2019 were selected as the research objects. According to the presence or absence of HHcy, the patients were divided into HHcy group and control group. The levels of homocysteine (Hcy) and blood lipid and the concentration of LCAT were detected. The correlations between the level of Hcy and the level of blood lipid and the concentration of LCAT were analyzed. Results　The levels of high density lipoprotein cholesterol (HDL-C) and apolipoprotein A Ⅰ (ApoA Ⅰ ) and the concentration of LACT in the HHcy group were significantly lower than that in the control group,and the differences were statistically significant (t =2.318, 2.405, 2.484, all P ＜ 0.05). The level of Hcy was significantly higher than that in the control group, and the difference was statistically significant (t =11.266，P ＜ 0.001). The level of Hcy was negatively correlated with the levels of HDL-C, ApoA Ⅰ and the concentration of LACT (r = － 0.197，P =0.008；r = － 0.212, P =0.006；r = － 0.221, P =0.005). Conclusion　HHcy is an independent risk factor for AS. HHcy may affect the function of ApoA Ⅰ , HDL and LCAT in reverse cholesterol transport (RCT) by reducing their levels, thereby promoting the occurrence and development of AS.

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备注/Memo

备注/Memo:
基金项目：西安市科技计划项目 [ 项目编号：201805102YX10SF36(6)]。 作者简介：赵佳（1984-），女，博士，副主任检验师，主要从事临床免疫及分子生物学检验工作，E-mail: 84911zj@163.com。 通讯作者：朱建伟（1971-），男，本科，副主任检验师，主要从事临床微生物学检验工作，E-mail: ysjj0603@sina.com。收稿日期：2019-08-25
更新日期/Last Update: 2019-12-25