[1]张丽洁a,袁晓华b,赵　园a,等.466例不良孕产史夫妇的细胞遗传学与临床特征分析[J].现代检验医学杂志,2019,34(06):67-69.[doi:10.3969 ／ j.issn.1671-7414.2019.06.016]
　ZHANG Li-jiea,YUAN Xiao-huab,ZHAO Yuana,et al.Analysis on Cytogenetics and Clinical Characteristics of 466 Couples with the History of Abnormal Gestation and Birth[J].Journal of Modern Laboratory Medicine,2019,34(06):67-69.[doi:10.3969 ／ j.issn.1671-7414.2019.06.016]
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466例不良孕产史夫妇的细胞遗传学与临床特征分析 ()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第34卷
期数:
2019年06期
页码:
67-69
栏目:
论著
出版日期:
2019-12-30

文章信息/Info

Title:
Analysis on Cytogenetics and Clinical Characteristics of 466 Couples with the History of Abnormal Gestation and Birth
文章编号:
1671-7414（2019）06-067-04
作者:
张丽洁a; 袁晓华b; 赵　园a; 王九菊a; 赵乔佳杰a; 魏绪仓a
( 陕西省人民医院a. 血液遗传研究所；b. 产科，西安　710068)
Author(s):
ZHANG Li-jiea;  YUAN Xiao-huab;  ZHAO Yuana;  WANG Jiu-jua;  ZHAO Qiao-jia-jiea;  WEI Xu-canga
（a.Institute of Hematology and Genetics；b. Department of Obstetrics, Shaanxi Provincial People’s Hospital, Xi’an 710068, China）
关键词:
不良孕产史; 染色体核型; 染色体畸变; 染色体多态性
分类号:
R714.2；Q343
DOI:
10.3969 ／ j.issn.1671-7414.2019.06.016
文献标志码:
A
摘要:
目的　探讨染色体异常与不良孕产史的关系。方法　选取466 例不良孕产史夫妇，采集其外周血进行淋巴细 胞培养及G 显带方法分析其染色体核型。80 例健康婚检夫妇为对照组。结果　466 例不良孕产史夫妇中发生染色体畸 变者14 例，检出率3.0%，其中结构异常10 例，数目异常4 例，染色体多态性携带者的检出率13.52% （63/466）。 健康婚检夫妇的畸变染色体检出率为1.25%（1/80），比不良孕产夫妇的畸变染色体检出率低，但差异无统计学意义 （χ2=0.874，P >0.05）。染色体多态性携带者检出率为5%（4/80），显著低于不良孕产史夫妇, 差异有统计学意义（χ2=5.082， P <0.05）。结论　染色体畸变和染色体多态性是不良孕产的重要因素。
Abstract:
Objective　To explore the relationship between chromosomal abnormalities and adverse pregnancy and childbirth history. Methods　466 couples with the history of abnormal gestation and birth were selected and their peripheral blood was collected for lymphocyte culture and G-banding to analyze their chromosome karyotypes. 80 couples for premarital health checkup were taken as control group. Results　Among 466 couples with adverse pregnancy and childbirth history, 14 had chromosomal aberration, the detection rate was 3.0%. Among them, 10 had structural abnormalities and 4 had numerical abnormalities. The detection rate of carriers of chromosomal polymorphism was 13.52% (63/466). The detection rate of aberrant chromosomes in healthy couples was 1.25% (1/80), lower than that in poor pregnant couples, but there was no significant difference (χ2=0.874, P >0.05). The detection rate of carriers of chromosome polymorphism was 5% (4/80), which was significantly lower than that in couples with poor pregnant and parturient history, the difference was statistically significant (χ2=5.082, P <0.05). Conclusion　Chromosome aberration and chromosome polymorphism are important factors in adverse pregnancy and delivery.

参考文献/References:

[1]　PYLYP L Y, SPYNENKO L O, VERHOGLYAD N V. et al. Chromosomal abnormalities in products of conception of first-trimester miscarriages detected by conventional cytogenetic analysis: a review of 1 000 cases [J]. Journal of Assisted Reproduction and Genetics, 2018, 35(2): 265-271.
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[3]　刘天盛，费冬梅，孙惟佳，等. 2 396 对自然流产 夫妇的细胞遗传学分析 [J]. 中华妇产科杂志, 2014, 49(8): 624-625. LIU Tiansheng, FEI Dongmei, SUN Weijia, et al. Cytogenetic analysis of 2 396 couples with spontaneous abortion [J]. Chinese Journal of Obstetrics and Gynecology, 2014, 49 (8): 624-625.
[4]　付爱红，苏坤华. 生殖异常夫妇染色体核型分析 [J]. 现代检验医学杂志, 2009, 24(6): 129-130. FU Aihong, SU Kunhua. Karyotype analysis of couples with reproductive abnormalities [J]. Journal of Modern Laboratory Medicine, 2009, 24 (6): 129-130.
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[6]　张建芳，陈必良，赵海波，等. 328 对不良孕产史 夫妇染色体核型分析 [J]. 现代检验医学杂志, 2009, 24(6): 125-127. ZHANG Jianfang, CHEN Biliang, ZHAO Haibo, et al. Chromosome analysis of 328 couples with unhealthy gravidity history [J]. Journal of Modern Laboratory Medicine, 2009, 24 (6): 125-127. 　

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备注/Memo

备注/Memo:
基金项目：国家自然科学基金（项目编号81200418）。 作者简介：张丽洁（1982-），女，博士，主治医师，从事细胞和分子遗传学诊断检测，E-mail: cyzlj8383@163.com。 通讯作者：魏绪仓（1962-），男，本科，研究员，二级教授，硕士生导师，从事血液遗传诊断工作，E-mail: weixucang62@sina.com 收稿日期：2019-08-07
更新日期/Last Update: 2019-12-25