[1]谈　昀a,马勇智b,雷　方c,等.2014~2018年临床患者送检样本肠球菌的菌种分布及耐药性分析[J].现代检验医学杂志,2019,34(06):93-96.[doi:10.3969 ／ j.issn.1671-7414.2019.06.023]
　TAN Yuna,MA Yong-zhib,LEI Fangc,et al.Species Distribution and Drug Resistance Analysis of Enterococcus from 2014 to 2018[J].Journal of Modern Laboratory Medicine,2019,34(06):93-96.[doi:10.3969 ／ j.issn.1671-7414.2019.06.023]
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2014~2018年临床患者送检样本肠球菌的菌种分布及耐药性分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第34卷
期数:
2019年06期
页码:
93-96
栏目:
论著
出版日期:
2019-12-30

文章信息/Info

Title:
Species Distribution and Drug Resistance Analysis of Enterococcus from 2014 to 2018
文章编号:
1671-7414（2019）06-093-04
作者:
谈　昀a; 马勇智b; 雷　方c; 刘　晶d; 王　文a
（武警陕西省总队医院a. 检验科；b. 卫勤处；c. 疾控科；d. 护理部，西安　710054）
Author(s):
TAN Yuna;  MA Yong-zhib;  LEI Fangc;  LIU Jingd;  WANG Wena
(a.Clinical Laboratory; b.Medical Office ；c.CDC Division； d. Department of Nursing, Shaanxi Corps Hospital of Chinese Peoples’s Armed Police Forces, Xi’an 710054，China）
关键词:
肠球菌; 屎肠球菌; 粪肠球菌; 耐药性
分类号:
R378.1；R446.5
DOI:
10.3969 ／ j.issn.1671-7414.2019.06.023
文献标志码:
A
摘要:
目的　探讨肠球菌属菌种分布及其耐药性，为临床治疗提供依据。方法　采用回溯性方法，收集2014 年1 月 ~2018 年12 月医院临床患者送检样本检出的肠球菌223 株，进行细菌鉴定及药物敏感性监测，并对数据进行统计分 析。结果　5 年来，223 株肠球菌多分布于泌尿外科、ICU，胃肠烧伤科、肾脏科等；标本主要来源于尿液、体液、血 液；其中分离出粪肠球菌123 株、屎肠球菌90 株、鸡肠球菌4 株、鸟肠球菌 3 株、坚韧球菌2 株和恶臭肠球菌1 株， 分离株主要为粪肠球菌占55.16%、屎肠球菌占40.36%；223 株肠球菌对大多数抗生素耐药率屎肠球菌均高于粪肠球菌 （χ2=9.184~93.217，P <0.05）, 而对四环素耐药率屎肠球菌低于粪肠球菌（χ2=23.207，P <0.05）；粪肠球菌、屎肠球菌 对高浓度的庆大霉素、利奈唑胺、万古霉素和替考拉宁的耐药率无统计学意义（P >0.05），而对氨苄西林尿肠球菌耐药 率（81.1%）与粪肠球菌耐药率（1.6%）相比差异有统计学意义（χ2=93.217，P <0.05），两者耐药性呈多重耐药，耐药 率逐年上升。结论　院内感染的肠球菌属主要以粪肠球菌、屎肠球菌为主；其耐药率逐年上升且呈多重耐药，但对利奈 唑胺、万古霉素、替考拉宁仍保持较好的敏感性，临床应建立完善的医院感染监测系统，根据药敏结果进行合理用药。
Abstract:
Objective　To study the distribution and drug resistance of Enterococci and provide evidence for clinical treatment. Methods　A retrospective method was used to collect 223 strains of Enterococci detected in samples from clinical patients in the hospital from January 2014 to December 2018 for bacterial identification and drug sensitivity monitoring, and statistical analysis was conducted on the data. Results　In the past five years, 223 strains of Enterococcus were distributed in urology, ICU, gastrointestinal burn and nephrology. The specimens mainly came from urine, body fluids and blood. Among them, 123 strains of Enterococcus faecalis, 90 strains of Enterococcus faecalis, 4 strains of Enterococcus gallinaceus, 3 strains of Enterococcus ornithae, 2 strains of tenacity coccus and 1 strain of Enterococcus malodorius were isolated. The isolates were mainly Eterococcus faecalis （55.16%）and Enterococcus faecium （40.36%）. The drug resistance rate of 223 Enterococcus faecalis was higher than that of Enterococcus faecium (χ2=9.184~93.217，all P <0.05), while the drug resistance rate of Enterococcus faecalis was lower than that of Enterococcus faecalis (χ2=23.207，P <0.05). In Enterococcus excrement Enterococcus to a high concentration of gentamicin, rina thiazole amine, vancomycin, their stead of ning percentages of no statistical significance (P > 0.05), and to ampicillin urine Enterococcus resistant rate (81.1%), and Enterococcus (1.6%) compared with dung the difference was statistically significant (χ2=93.217, P < 0.05), and both resistance in multiple drug resistance, resistance to rise year by year. Conclusion　Enterococci were mainly faecalis Enterococcus and faecium Enterococcus in nosocomial infection. The drug resistance rate increased year by year and showed multiple drug resistance, but it still maintained a good sensitivity to linezolid, vancomycin and tikoranin. Therefore, a perfect nosocomial infection monitoring system should be established in clinical practice and rational drug use should be conducted according to the drug sensitivity results.

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备注/Memo

备注/Memo:
作者简介：谈 昀(1972-)，女，副主任技师，主要从事微生物及免疫学工作，E-mail： chhhty@sina.com。 通讯作者：刘 晶，E-mail： 1972820192@qq.com。收稿日期：2019-08-16
更新日期/Last Update: 2019-12-25