[1]李贤见,黄裕林,易　宏,等.重庆市开州地区 0~6岁儿童 25-羟基维生素 D水平调查及相关危险因素分析[J].现代检验医学杂志,2019,34(06):130-134.[doi:10.3969 ／ j.issn.1671-7414.2019.06.033]
　LI Xian-jian,HUANG Yu-lin,YI Hong,et al.Investigation of 25-Hydroxyvitamin D Level and Analysis of Related Risk Factors in Children Aged 0~6 Years in Kaizhou District of Chongqing[J].Journal of Modern Laboratory Medicine,2019,34(06):130-134.[doi:10.3969 ／ j.issn.1671-7414.2019.06.033]
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重庆市开州地区 0~6岁儿童 25-羟基维生素 D水平调查及相关危险因素分析 ()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第34卷
期数:
2019年06期
页码:
130-134
栏目:
检验与临床
出版日期:
2019-12-30

文章信息/Info

Title:
Investigation of 25-Hydroxyvitamin D Level and Analysis of Related Risk Factors in Children Aged 0~6 Years in Kaizhou District of Chongqing
文章编号:
1671-7414（2019）06-130-05
作者:
李贤见; 黄裕林; 易　宏; 黎　妮
（重庆市开州区人民医院检验科，重庆　405499）
Author(s):
LI Xian-jian;  HUANG Yu-lin; YI Hong; LI Ni
（Department of Clinical Laboratory of Kaizhou District People’s Hospital of Chongqing, Chongqing 405499,China）
关键词:
儿童; 25- 羟基维生素D; 危险因素
分类号:
R446.112
DOI:
10.3969 ／ j.issn.1671-7414.2019.06.033
文献标志码:
A
摘要:
目的　分析重庆市开州地区0~6 岁儿童25- 羟基维生素D[25-（OH）D] 水平及相关危险因素，为防治因25-（OH） D 缺乏或不足引起的相关疾病提供依据。方法　选取1 486 例0~6 岁儿童为研究对象，采用磁微粒化学发光免疫分析法 进行25-（OH）D 检测，从性别、年龄、季节方面分析25-（OH）D 水平，并对可能引起其缺乏或不足的相关危险因素 进行单因素及多因素分析。结果　1 486 例0~6 岁儿童血清25- （OH）D缺乏率为21.6%（321/1 486），不足率为29.54%（439/1 486），充足率为48.86%（726/1 486），男女儿童间25-（OH）D 缺乏、不足和充足率差异无统计学意义（χ2=0.472， P >0.05）；3~6 岁儿童25-（OH）D 水平显著低于<1 岁、1~2 岁和2~3 岁儿童（26.18±7.52 ng/ml vs 29.66±8.88 ng/ ml，31.36±9.83 ng/ml and 30.84±8.24 ng/ml），差异具有统计学意义（F =19.529，P <0.01），不同年龄段的儿童25- （OH）D 缺乏率、不足率和充足率差异具有统计学意义（χ2=23.730，P <0.01）；夏、秋季儿童25-（OH）D 水平高于春、 冬季（33.11±9.29 ng/ml，32.73±9.46 ng/ml vs 27.28±8.82 ng/ml，26.51±7.23 ng/ml），不同季节的25-（OH）D 缺乏 率、不足率和充足率差异具有统计学意义（χ2=89.795，P <0.01 ）。单因素分析显示：单独母乳喂养、未规律服用维生 素D 制剂、挑食或厌食、户外活动时间< 2h/ 天、父母文化程度低、反复腹泻是引起受检儿童25-（OH）D 缺乏或 不足的影响因素（χ2=5.823，25.758，10.531，5.666，6.973，4.707，均P <0.05）；多因素分析显示：挑食或厌食、反 复腹泻是引起0~6 岁受检儿童25-（OH）D 缺乏或不足的独立危险因素（χ2=85.690，6.392，均P <0.05）。结论　开州 地区0~6 岁儿童25-（OH）D 缺乏或不足的情况较为严重，应在春、冬季和儿童在3~6 岁阶段进行维生素D 制剂补充； 加强儿保教育，纠正引起儿童25-（OH）D 缺乏或不足的相关危险因素。
Abstract:
Objective　To analyze the level of 25-hydroxyvitamin D[25-（OH）D] and its related risk factors in children aged 0~6 years in Kaizhou of Chongqing in order to provide evidence for the prevention and treatment of related diseases caused by 25-（OH）D deficiency or insufficiency. Methods　A total of 1 486 children aged 0~6 years were selected as subjects. 25-（OH） D was detected by magnetic particle chemiluminescence immunoassay. The levels of 25-（OH）D were analyzed in terms of sex, age and season, and the related risk factors that might cause their deficiency or deficiency were analyzed by single factor and multi-factor analysis. Results　The serum 25-（OH） D deficiency rate was 21.6% （321/1 486）, deficiency rate was 29.54% （439/1 486） and adequacy rate was 48.86% （726/1 486） in 1 486 children aged 0~6 years. There was no significant difference in 25-（OH） D deficiency, insufficiency and adequacy rate between boys and girls （χ2=0.472, P >0.05）. The level of 25-（OH）D in children aged 3~6 years was significantly lower than that in children aged < 1,1~2 and 2~3 years （26.18±7.52 ng/ml vs 29.66±8.88 ng/ml, 31.36±9.83 ng/ml and 30.84±8.24 ng/ml），respectively, the difference was statistically singnificant（F =19.529，P <0.01） . There were significant differences in the rate of 25-（OH）D deficiency, insufficiency and adequacy among children of different ages （χ2=23.730，P <0.01）. The levels of 25-（OH）D in summer and autumn was higher than that in spring and winter （33.11±9.29 ng/ml，32.73±9.46 ng/ml vs 27.28±8.82 ng/ml，26.51±7.23 ng/ml）. There were significant differences in the rate of 25-（OH）D deficiency, insufficiency and adequacy in different seasons （χ2=89.795，P <0.01）. Univariate analysis showed that breastfeeding alone, irregular use of vitamin D preparations, picky or anorexia, outdoor activities less than 2 hours/day, low educational level of parents and recurrent diarrhea were risk factors for 25-（OH） D deficiency or insufficiency （χ2=5.823, 25.758, 10.531, 5.666, 6.973, 4.707, all P <0.05）. Analysis showed that picky eating, anorexia and recurrent diarrhea were independent risk factors for 25-（OH） D deficiency or deficiency in children aged 0~6 years （χ2= 85.690, 6.392, all P <0.05）.Conclusion　The situation of 25-（OH） D deficiency and insufficiency in children aged 0~6 years in Kaizhou is serious.Vitamin D supplementation should be carried out in spring, winter and children aged 3~6 years, and the education of child care should be strengthened to correct the related risk factors of 25-（OH）D deficiency and insufficiency in children.

参考文献/References:

[1]　MUSA I R , RAYIS D A , AHMED M A , et al. Thyroid function and 25 （OH） vitamin D level among sudanese women in early pregnancy[J]. Macedonian Journal of Medical Sciences,2018,6（3）:488-492.
[2]　丁帅.0~7 岁儿童血清25-（OH）D 水平与骨密度的 相关性研究[J]. 中国妇幼保健,2018,33（08） :1790- 1792. DING Shuai.Study on the correlation between serum 25-（OH）D level and bone mineral density in children aged 0-7 years [J].Maternal and Child Health Care of China,2018,33（8）:1790-1792.
[3]　李 旭, 罗朋立. 维生素D 在系统性红斑狼疮中的免 疫调控作用[J]. 生理科学进展,2018,49（2）:125-129. LI Xu,LUO Pengli. The role of vitamin D in immune regulation in systemic lupus erythematosus [J].Progress in Physiological Science,2018,49（2）:125-129.
[4]　MAHENDRA A , KARISHMA, CHOUDHURY B K , et al. Vitamin D and gastrointestinal cancer.[J]. Journal of Laboratory Physicians,2018,10（1）:1-5.
[5]　MADDALONI E ,CAVALLARI I ,NAPOLI N ,et al. Vitamin D and diabetes mellitus.[J]. Frontiers of Hormone Research,2018,50（3）:161-176.
[6]　GHOSN J, VIARD J P. Vitamin D and infectious diseases[J]. Presse Médicale,2013, 42（10）:1371-1376.
[7]　IEGARTH C, GRIMM D, WEHLAND M, et al. The impact of vitamin D in the treatment of essential hypertension[J]. International Journal of Molecular Sciences, 2018,19（2）:E455.
[8]　BIKLE D , BOUILLON R , THADHANI R , et al. Vitamin D metabolites in captivity? Should we measure free or total 25（OH）D to assess vitamin D status?[J]. The Journal of Steroid Biochemistry and Molecular Biology, 2017,173:105-116.
[9]　SURYANARAYANA P , ARLAPPA N , SAI SANTHOSH V , et al. Prevalence of vitamin D deficiency and its associated factors among urban elderly population in Hyderabad metropolitan city, South India[J]. Annals of Human Biology,2018, 45（2）:133-139.
[10] PEREIRA-SANTOS M , QUEIROZ CARVALHO G , DAVID COUTO R , et al. Vitamin D deficiency and associated factors among pregnant women of a sunny city in Northeast of Brazil[J]. Clinical Nutrition Espen,2018,23（2）:240-244.
[11] 刘锦平, 王金凤.0~3 岁婴幼儿维生素D 水平检测结 果及缺乏的风险因素分析[J]. 中国妇幼保健,2018,33 （15）:3466-3468. LIU Jinping，Wang Jinfeng. Detection results of vitamin D levels in infants aged 0~3 years old and analysis on the risk factors of Vitmin D deficiency [J].Maternal and Child Health Care of China,2018,33（15）:3466- 3468.
[12] 王娴, 刘华伟, 邓 彪. 成都地区学龄前儿童25 羟基 维生素D 水平调查[J]. 检验医学与临床,2016,13 （5）:644-645，648. WANG Xian，LIU Huawei, DENG Biao. Study on levels of 25-hydroxy vitamin D among preschool children in Chengdu area [J].Laboratory Medicine and Clinical,2016,13（5）: 644-645，648.
[13] 易聪, 吴红, 张帆, 等. 海南省贫困地区中小学生血 清维生素D 水平分析[J]. 中国学校卫生,2018,39 （1）:111-113. YI Cong, WU Hong, ZHANG Fan, et al. Analysis of serum vitamin D levels of primary and secondary school students in poverty-stricken areas of hainan province [J]. Chinese Journal of School Health, 2018,39（1）:111-113.
[14] 袁明生, 吴起武.120 例0~6 岁儿童血清25- 羟基 维生素D 水平的调查[J]. 中国妇幼保健,2015,30 （14）:2234-2236. YUAN Mingsheng, WU Qiwu. Investigation on serum 25-hydroxy vitamin D level among 120 children aged 0-6 years old [J]. Maternal and Child Health Care of China,2015,30 （14）: 2234-2236.
[15] 陈国微. 丽水市区儿童保健门诊0~6 岁儿童血清 25- 羟维生素D 水平调查[J]. 中国农村卫生事业管 理,2016,36（2）:231-233. CHEN Guowei.Investigation on serum 25-hydroxyvitamin D level of children aged 0-6 years in children health clinic of Lishui city [J].Chinese Rural Health Service Administration, 2016,36（2）:231-233.

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备注/Memo

备注/Memo:
作者简介：李贤见（1986-）男，本科，主管检验师，研究方向：临床基础检验和流式细胞学，E-mail：308216706@qq.com 收稿日期：2019-03-12
更新日期/Last Update: 2019-12-25