[1]张红雨,陆奉科,李 山,等.子宫内膜癌患者血清CA125 水平与外周血RDW 检测在临床病理分期中的应用价值[J].现代检验医学杂志,2020,35(01):94-96.[doi:10.3969/j.issn.1671-7414.2020.01.025]
　ZHANG Hong-yu,LU Feng-ke,LI Shan,et al.Value of Serum CA125 Level and Peripheral Blood RDW Detectionin Clinical Pathological Staging of Patients with Endometrial Cancer[J].Journal of Modern Laboratory Medicine,2020,35(01):94-96.[doi:10.3969/j.issn.1671-7414.2020.01.025]
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子宫内膜癌患者血清CA125 水平与外周血RDW 检测在临床病理分期中的应用价值()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年01期
页码:
94-96
栏目:
论　　著
出版日期:
2020-02-29

文章信息/Info

Title:
Value of Serum CA125 Level and Peripheral Blood RDW Detection in Clinical Pathological Staging of Patients with Endometrial Cancer
文章编号:
1671-7414(2020)01-094-04
作者:
张红雨; 陆奉科; 李 山; 秦 雪
(广西医科大学,南宁 530021)
Author(s):
ZHANG Hong-yu;  LU Feng-ke;  LI Shan;  QIN Xue(
Guangxi Medical University, Nanning 530021,China)
关键词:
红细胞分布密度;  糖类抗原125;  子宫内膜癌
分类号:
R737.33; R730.43
DOI:
10.3969/j.issn.1671-7414.2020.01.025
文献标志码:
A
摘要:
目的 探讨子宫内膜癌患者血清糖类抗原125(CA125)水平与外周血红细胞分布宽度(RDW)检测在临床病理分期中的应用价值。方法 以柳州市中医医院东院2019年1～7月收集的81例子宫内膜癌患者的临床资料作为观察组,并抽取40例健康体检人员作为对照组,采用分组t检验比较丙氨酸氨基转移酶(ALT)、总蛋白(TP)、肌酐、尿素(UREA)和CA125在观察组与对照组之间的差异; 另外子宫内膜癌患者被分为Ⅰ～Ⅱ组和Ⅲ～Ⅳ组,比较RDW与CA125在两组之间的差异; 通过受试者工作特征曲线(receiver operating characteristic curve,ROC曲线)分析评价RDW与CA125联合诊断子宫内膜癌的价值。结果 RDW与CA125在观察组与对照组之间存在明显差异(P<0.05),RDW在Ⅰ～Ⅱ组和Ⅲ～Ⅳ组之间存在明显差异(t=-4.85,P<0.05),而CA125在Ⅰ～Ⅱ组和Ⅲ～Ⅳ组之间差异无统计学意义(t=-0.90,P= 0.370)。CA125, RDW诊断子宫内膜癌的ROC曲线下面积(AUC)分别为0.821(95%置信区间为0.749～0.894)和0.819(95%置信区间为0.746～0.892),而两者联合诊断子宫内膜癌的AUC为0.914(95%置信区间为0.866～0.962)。结论 检测子宫内膜癌患者外周血RDW对其临床病理分期有重要的应用价值。
Abstract:
Objective To explore the application value of serum CA125 level and peripheral blood RDW detection in clinical pathological staging of patients with endometrial cancer. Methods 81 patients with endometrial cancer in Liuzhou Chinese Medicine Hospital from January to July 2019 were used as observation groups. 40 healthy subjects were selected as control. Independent samples t-test was used to compare alanineaminotransferase, total protein, creatinine, urea and CA125 in the observation group and the control group.Endometrial cancer patients were divided into I～II group and III～IV group, comparing the difference between RDW and CA125 in the two groups. The value of RDW combined with CA125 in the diagnosis of endometrial cancer was evaluated by the receiver operating characteristic(ROC)curve. Results There was a significant difference between RDW and CA125 in the observation group and the control group(P<0.05). There was a significant difference in RDW between group I～II and group III～IV(t=-4.85,P<0.05), while there was no significant difference in CA125 between group I～II and group III～IV(t=-0.90,P=0.370). The area under the ROC curve(AUC)for diagnosis of endometrial cancer for CA125 was 0.821(95% confidence interval 0.749～0.894),0.819(95% confidence interval 0.746～0.892)for RDW, and the AUC of the combined diagnosis of endometrial cancer was 0.914(95% confidence interval 0.866～0.962),respectively. Conclusion Detection of peripheral blood RDW in patients with endometrial cancer has important application value in clinical pathological staging.

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备注/Memo

备注/Memo:
作者简介:张红雨(1986-),男,研究生,主管检验师,研究方向:临床检验诊断学,E-mail: 360328467@qq.com。 通讯作者:秦雪(1963-),女,医学博士,主任医师,博士研究生导师。 收稿日期:2019-07-12 修回日期:2019-07-28
更新日期/Last Update: 2020-03-30