[1]梁培松,王结珍,陈 康,等.孕早期年龄,BMI 和PAPPA 水平综合评价对GDM 的预测价值[J].现代检验医学杂志,2020,35(01):133-135.[doi:10.3969/j.issn.1671-7414.2020.01.035]
　LIANG Pei-song,WANG Jie-zhen,CHEN Kang,et al.Predictive Value of Comprehensive Evaluation of Early Pregnant Age,BMI and PAPPA Levels to the GDM[J].Journal of Modern Laboratory Medicine,2020,35(01):133-135.[doi:10.3969/j.issn.1671-7414.2020.01.035]
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孕早期年龄,BMI 和PAPPA 水平综合评价对GDM 的预测价值()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年01期
页码:
133-135
栏目:
检验与临床
出版日期:
2020-02-29

文章信息/Info

Title:
Predictive Value of Comprehensive Evaluation of Early Pregnant Age,BMI and PAPPA Levels to the GDM
文章编号:
1671-7414(2020)01-133-03
作者:
梁培松; 王结珍; 陈 康; 王伟佳
(中山大学附属中山市人民医院检验医学中心,广东中山 528403)
Author(s):
LIANG Pei-song; WANG Jie-zhen; CHEN Kang; WANG Wei-jia
(Department of Clinical Laboratory,the People's Hospital ofZhongshanAffiliated to Sun Yat-sen University, Guangdong Zhongshan 5284003,China)
关键词:
妊娠糖尿病;  身体质量指数;  年龄;  妊娠相关血浆蛋白A
分类号:
R714.256; R446.11
DOI:
10.3969/j.issn.1671-7414.2020.01.035
文献标志码:
A
摘要:
目的 探讨孕早期年龄、身体质量指数(body mass index,BMI)和妊娠相关血浆蛋白A(pregnancy-associated plasma protein A,PAPPA)综合评价对妊娠糖尿病(gestational diabetes mellitus,GDM)的预测价值。方法 选取365例孕妇作为研究对象,其中GDM孕妇112例,非GDM孕妇253例; 收集孕妇孕期检查资料,分析孕妇孕早期BMI,年龄和PAPPA值等与GDM的相关性。结果 GDM组年龄、BMI,空腹血糖(gestational diabetes mellitus,FPG),餐后1h血糖(1hPG)和餐后2h血糖(2hPG)均高于对照组,差异具有统计学意义(t=-21.836～-0.459,均P=0.000); PAPPA与2hPG有显著相关性(r =-0.242,P=0.010); PAPPA,BMI及年龄与GDM有显著相关性(wald=7.011,7.174,20.476, 均P=0.000); PAPPA单项所得ROC曲线与联合(PAPPA+BMI+年龄)所得比较,差异无统计学意义(z=1.667,P=0.095)。PAPPA,BMI+年龄及PAPPA+BMI+年龄的敏感度、特异度和诊断准确度均<0.7,诊断比值比均<1。结论 PAPPA,BMI和年龄对GMD有一定的预测价值,但有限。
Abstract:
Objective To explore the gestational diabetes mellitus(GDM)predictive value of early pregnant women age,BMI and PAPPA. Methods 365 cases of pregnant women were selected as the research object,112 cases pregnant women were with GDM and 253 cases pregnant women were not,and the pregnant women clinical information were collected during pregnancy. The correlation of early pregnant women BMI,age,PAPPA and GDM were analyzed.Results The age,BMI,FPG,1hPG and 2hPG of GDM group were higher than the control group,and the difference was statistically significant(t=-21.836 ～-0.459,all P=0.000). The correlation of PAPPA and 2hPG were statistically significant(r=-0.242,P=0.010).PAPPA,BMI and age were significantly correlated with GDM(wald=7.011,7.174,20.476,all P =0.000).The ROC curve of individual PAPPA and cobination income(PAPPA+BMI+age)compared were no statistically significant difference(z=1.1.667, P=0.095), and the sensitivity,specificity and diagnosis accuracy of PAPPA, BMI and PAPPA + BMI+age were <0.7,with all Diagnostic odds ratio < 1.Conclusion PAPPA, BMI and age have a certain extent predictive value of GDM,but limited.

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备注/Memo

备注/Memo:
基金项目:2017年度中山市社会公益科技研究专项立项项目(2017B1024 )。 作者简介:梁培松(1976-),男,本科,副主任技师,主要从事临床检验免疫学工作和研究,E-mail:mark113388@163.com。 通讯作者:王伟佳,男,硕士研究生导师,博士后,主任技师,E-mail:xuelangchichao@163.com。 收稿日期:2019-02-20 修回日期:2019-04-01
更新日期/Last Update: 2020-03-30