[1]陈伟芝,张　宁.高血压病患者血清CXCL9 和 SGK1 水平检测与心肌纤维化的相关性研究[J].现代检验医学杂志,2020,35(03):47-50.[doi:10.3969/j.issn.1671-7414.2020.03.011]
　CHEN Wei-zhi,ZHANG Ning.Correlation between Serum CXCL9 and SGK1 Levels and Myocardial Fibrosis in Hypertension[J].Journal of Modern Laboratory Medicine,2020,35(03):47-50.[doi:10.3969/j.issn.1671-7414.2020.03.011]
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高血压病患者血清CXCL9 和 SGK1 水平检测与心肌纤维化的相关性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年03期
页码:
47-50
栏目:
论著
出版日期:
2020-07-20

文章信息/Info

Title:
Correlation between Serum CXCL9 and SGK1 Levels and Myocardial Fibrosis in Hypertension
文章编号:
1671-7414（2020）03-047-04
作者:
陈伟芝1;  张　宁2
（1. 西安交通大学附属红会医院检验科，西安　710054；2. 咸阳市泾阳县医院检验科，陕西泾阳　713700）
Author(s):
CHEN Wei-zhi1;  ZHANG Ning2
（1. Department of Clinical Laboratory, Honghui Hospital Affiliated to Xi’an Jiaotong University,Xi’an 710054, China; 2. Department of Clinical Laboratory, the Hospital of Jingyang County, Shaanxi Jingyang 713700, China）
关键词:
高血压; 心肌纤维化; T1 值; 心肌细胞外容积分数（ECV）; 血清糖皮质激素诱导蛋白激酶1 （ SGK1）; CXC 趋化因子配体9（CXCL9）
分类号:
R544.1；R392.11
DOI:
10.3969/j.issn.1671-7414.2020.03.011
摘要:
目的　探讨血清CXC 趋化因子配体9(CXC chemokine ligand,CXCL9) 和血清糖皮质激素诱导蛋白激酶1(serum glucocorticoid-inducible kinase 1，SGK1) 水平与高血压病患者心肌纤维化的相关性。方法　收集2018 年9 月～ 2019 年9 月期间在西安交通大学附属红会医院就诊的93 例原发性高血压患者的临床资料进行回顾性分析。依据心肌增强 前T1 值及心肌细胞外容积分数(extracellular volume fraction，ECV) 将高血压患者分为纤维化组(53 例) 和非纤维化组 (40 例)。血清CXCL9 和 SGK1 水平采用酶联免疫吸附法检测；采用心脏磁共振纵向弛豫时间T1(T1mapping) 成像技术 测定心肌增强前T1 值及细胞外容积分数(extracellular volume fraction,ECV) 评价心肌纤维化程度。选择45 例同期体检 健康者作为对照组，比较分析以上指标的变化与高血压心肌纤维化的相关性。结果　在对照组、非纤维化组和纤维化 组中，血清CXCL9(ng/ml) 和SGK1(pg/L) 水平分别为7.20±2.08, 8.73±2.50, 11.09±3.67 和24.39±6.23, 40.79±12.85, 52.67±15.32。与对照组比较，纤维化组和非纤维化组的CXCL9 和SGK1 水平均显著增高，纤维化组增高更显著 (F=135.93 ～ 167.96, P 均=0.000)。在纤维化组中, 血清SGK1 和CXCL9 水平有正相关性(r=0.869，P<0.01)。在纤维化 组中，SGK1 和CXCL9 水平分别与增强前T1 值和ECV 有正相关性(rSGK1=0.857, 0.803, rCXCL9=0.842, 0.797, 均P<0.01)。结 论 　SGK1 及CXCL9 与高血压心肌纤维化的发生发展有关。检测血清SGK1 及CXCL9 水平可以预测高血压心肌纤维 化的发生并为其治疗提供理论依据。
Abstract:
Objective　To investigate the correlation between serum CXC chemokine ligand 9(CXCL9), serum and glucocorticoid inducible kinase 1 (SGK1) levels and myocardial fibrosis in patients with hypertension. Methods　The clinical data of 93 patients with essential hypertension from September 2018 to September 2019 in Honghui Hospital Affiliated to Xi’an Jiaotong University were collected for retrospective analysis. According to the results of T1 value before myocardial enhancement and extracellular volume fraction (ECV) measured by T1 mapping, the patients were divided into fibrosis group (53 cases) and non fibrosis group (40 cases).45 healthy persons in the same period were selected as the control group.45 healthy persons in the same period were selected as the control group.The correlation between the changes of the above indexes and the myocardial fibrosis in hypertension was compared and analyzed. Results　In the control group, non fibrosis group and fibrosis group, the serum levels of CXCL9 (ng / ml) and SGK1 (pg / L) were 7.20±2.08, 8.73±2.50, 11.09± 3.67 and 24.39±6.23, 40.79±12.85,52.67±15.32,respectively . Compared with the control group, the levels of CXCL9 and SGK1 in fibrosis group and non fibrosis group were significantly higher with a more significant increase in fibrosis group(F=135.93~167.96，P=0.000). In fibrosis group, SGK1 and CXCL9 were positively correlated (r= 0.869, P<0.01). In fibrosis group, SGK1 and CXCL9 was positively correlated with pre enhanced T1 and ECV(rSGK1=0.857,0.803， rCXCL9=0.842, 0.797，all P<0.01). Conclusion　SGK1 and CXCL9 are related to the occurrence and development of myocardial fibrosis in hypertension. The detection of the levels of SGK1 and CXCL9 in serum can predict the occurrence of myocardial fibrosisand provide theoretical basis for its treatment.

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备注/Memo

备注/Memo:
收稿日期：2020-01-16 修回日期：2020-01-30作者简介：陈伟芝（1984-），女，本科学历，主管检验师，研究方向：高血压疾病的实验室诊断，E-mail：2191515872@qq.com。 通讯作者：张宁（1973-），女，本科学历，主管检验师，研究方向：高血压疾病的实验室诊断，E-mail：1787320474@qq.com。
更新日期/Last Update: 2020-07-20