[1]赵顺锋,胡慧营,王建红,等.血清25(OH)D，SOD，Hcy，hs-CRP 及脂类水平检测与高血压病的关系研究[J].现代检验医学杂志,2020,35(03):51-54.[doi:10.3969/j.issn.1671-7414.2020.03.012]
　ZHAO Shun-feng,HU Hui-ying,WANG Jian-hong,et al.Study on the Relationship between the Levels of Serum 25 (OH) D, SOD, Hcy, hsCRP and Lipids and Hypertension[J].Journal of Modern Laboratory Medicine,2020,35(03):51-54.[doi:10.3969/j.issn.1671-7414.2020.03.012]
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血清25(OH)D，SOD，Hcy，hs-CRP 及脂类水平检测与高血压病的关系研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年03期
页码:
51-54
栏目:
论著
出版日期:
2020-07-20

文章信息/Info

Title:
Study on the Relationship between the Levels of Serum 25 (OH) D, SOD, Hcy, hsCRP and Lipids and Hypertension
文章编号:
1671-7414（2020）03-051-04
作者:
赵顺锋;  胡慧营;  王建红;  张付丽;  程广杰;  祝　慧
（聊城市第三人民医院检验科，山东聊城　252000）
Author(s):
ZHAO Shun-feng;  HU Hui-ying;  WANG Jian-hong;  ZHANG Fu-li;  CHENG Guang-jie;  ZHU Hui
（Department of Clinical Laboratory, the Third People’s Hospital of Liaocheng, Shandong Liaocheng　252000, China）
关键词:
高血压; 25 羟维生素D;  超氧化物歧化酶;  同型半胱氨酸;  超敏C 反应蛋白
分类号:
R544.1；R446.112
DOI:
10.3969/j.issn.1671-7414.2020.03.012
摘要:
目的　探讨25 羟维生素D[25(OH)D]、超氧化物歧化酶（SOD）、同型半胱氨酸（Hcy）、超敏C 反应蛋白（hs- CRP）及脂类指标与高血压的关系。方法　采用病例对照研究方法，选取2017 年1 月~ 2019 年7 月期间入住聊城市第三 人民医院心内科的高血压患者220 例及40 例年龄匹配的查体健康者。采用免疫比浊法检测25(OH)D，hs-CRP，循环酶法 检测Hcy，比色法检测SOD，同时检测两组总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）和低密 度脂蛋白胆固醇（LDL-C）水平。运用logistic 回归模型评价与高血压相关的风险因子，受试者工作曲线（ROC）预测各 指标在高血压诊治中的价值。结果　观察组25(OH)D, HDL-C 显著低于对照组，差异有统计学意义（Z= -3.018，-3.838， 均P ＜ 0.01）; 观察组Hcy 显著高于对照组，差异有统计学意义（Z = - 3.378，P ＜ 0.01）; logistic 回归分析25(OH)D, Hcy, HDL-C 是评估高血压的风险因素，OR 值分别为1.070, 0.876 和9.160。ROC 曲线显示，25(OH)D，Hcy 和HDL-C 诊断高 血压的曲线下面积（AUC）分别为0.650, 0.668 和0.691，最佳界值为20.61, 13.41 和1.36。结论　血清25(OH)D, HDL-C 和 Hcy 表达是高血压诊治中的风险因子。
Abstract:
Objective　To investigate the relationship between the levels 25 hydroxyvitamin D [25 (OH) D], superoxide dismutase (SOD), homocysteine (Hcy), hypersensitive C-reactive protein (hs-CRP), lipid index and hypertension. Methods　A case-control study were conducted，220 cases of hypertensive patients and 40 cases of age-matched healthy subjects were selected from the Department of Cardiology of the Third People’s Hospital of Liaocheng from January 2017 to July 2019.The levels of 25 (OH)D, hsCRP, Hcy, SOD, TC, TG, HDL-C and LDL-C were measured by immunoturbidimetry and colorimetry, respectively. Logistic regression model was used to evaluate the risk factors related to hypertension, and ROC curve was used to predict the value of each index in the diagnosis and treatment of hypertension. Results　25 (OH)-D and HDL-C in the observation group were significantly lower than those in the control group, and the difference was statistically significant (Z values were -3.018, -3.838, all P< 0.01). Hcy in the observation group was significantly higher than that in the control group, and the difference was statistically significant (Z = -3.378, P < 0.01). 25 (OH)D, Hcy and HDL-C in the logistic regression analysis were risk factors for hypertension, or values were 1.070, 0.876 and 9.160, respectively. ROC curve showed that AUC of 25 (OH)D, Hcy and HDL-C was 0.650, 0.668 and 0.691, respectively, and the best boundary value was 20.61, 13.41 and 1.36, respectioely. Conclusion　The expression of serum 25 (OH) VD, HDL-C and Hcy are risk factors in the diagnosis and treatment of hypertension.

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备注/Memo

备注/Memo:
收稿日期：2019-12-12 修回日期：2020-01-14基金项目：国家科技支撑计划项目（2015BAI32H00），中关村高精尖项目（2019F000G284）。 作者单位：赵顺锋（1973-），男，本科，副主任技师，研究方向：生化免疫、分子生物学，E-mail：lcsyzsf@yeah.net
更新日期/Last Update: 2020-07-20