[1]李晓丽,赵　莉,曹阳阳,等.多囊卵巢综合征患者血清肌联素水平表达与多种生化代谢指标的相关性分析[J].现代检验医学杂志,2020,35(06):111-113.[doi:doi:10.3969/j.issn.1671-7414.2020.06.027]
　LI Xiao-li,ZHAO Li,CAO Yang-yang,et al.Correlation Analysis between Expression of Serum Myonectin and VariousBiochemical and Metabolic Indexes in Patients with Polycystic Ovary Syndrome[J].Journal of Modern Laboratory Medicine,2020,35(06):111-113.[doi:doi:10.3969/j.issn.1671-7414.2020.06.027]
点击复制

多囊卵巢综合征患者血清肌联素水平表达与多种生化代谢指标的相关性分析()
分享到：

《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年06期
页码:
111-113
栏目:
论著
出版日期:
2020-12-30

文章信息/Info

Title:
Correlation Analysis between Expression of Serum Myonectin and VariousBiochemical and Metabolic Indexes in Patients with Polycystic Ovary Syndrome
文章编号:
1671-7414（2020）06-111-04
作者:
李晓丽1 ; 赵　莉2 ; 曹阳阳2; 马文鹏
(1. 宝鸡市妇幼保健院妇科，陕西宝鸡 721000；2. 西安高新医院妇科，西安 710075)
Author(s):
LI Xiao-li 1 ;  ZHAO Li 1 ;  CAO Yang-yang;  MA Wen-peng 1
(1. Department of Gynaecology,Baoji Maternal and Child Health Care Hospital, Shaanxi Baoji 721000, China;2. Gynaecology Department, Xi’an Gaoxin Hospital, Xi’an 710075, China)
关键词:
多囊卵巢综合征; 肌联素; 生化代谢指标
分类号:
R711.75；R446.112
DOI:
doi:10.3969/j.issn.1671-7414.2020.06.027
文献标志码:
A
摘要:
目的　探究多囊卵巢综合征 (polycystic ovary syndrome, PCOS) 患者血清肌联素 (myonectin) 水平表达与多种生化代谢指标的相关性分析。方法　选取 2018 年 5 月 ~2019 年 11 月宝鸡市妇幼保健院收治的 55 例 PCOS 患者为观察组，另选取 58 例同期体检健康女性为对照组。收集两组的空腹血糖 (fasting blood glucose, FBG)、总胆固醇 (total cholesterol,TC)、三酰甘油 (triglyceride, TG)、高密度脂蛋白胆固醇 (high density lipoprotein-cholesterol, HDL-C)、低密度脂蛋白胆固醇(low density lipoprotein-cholesterin, LDL-C)、超敏C反应蛋白(hypersensitive C-reactive protein, hs-CRP)、游离睾酮（freetestosterone, FT）、卵泡刺激素（follicle-stimulating hormone, FSH）和促黄体生成素（luteinizing horuone, LH）等生化代谢指标。采用酶联免疫吸附法 (ELISA) 检测受试者血清中 Myonectin 的水平。结果　两组的 hs-CRP，FT 和 Myonectin水平差异均具有统计学意义 (t=0.43,11.6,13.6, 均 P ＜ 0.001)，且观察组的 hs-CRP 和 FT 水平高于对照组 (P< 0.05)，观察组的 Myonectin 为 10.40±4.18 ng/ml，显著高于对照组的 6.45±2.07 ng/ml。Myonectin 高、低表达组的 TC，LDL-C，HDL-C，hs-CRP，FSH，LH 和 FT 水平差异均无统计学意义 (t=1.714，0.504，0.108，0.667，0.374，0.674，0.527，均 P ＞ 0.05)，Myonectin 高、低表达组的 FBG 和 TG 水平差异具有统计学意义 (t=14.384，15.195，均 P ＜ 0.05)。Spearman 相关性分析，血清 Myonectin 水平与 FBG，TG 呈正相关关系 (r s 值分别为 0.074 和 0.681，P ＜ 0.05)。结论Myonectin 是 PCOS 的潜在生物学标记物，其与 FBG，TG 呈正相关关系。

参考文献/References:

[1] SELDIN M M, PETERSON J M, BYERLY M S, etal. Myonectin (CTRP15), a novel myokine that linksskeletal muscle to systemic lipid homeostasis[J]. J BiolChem. 2012;287(15):11968-11980.
[2] LITTLE H C, RODRIGUEZ S, LEI Xia, et al. Myonec-tin deletion promotes adipose fat storage and reducesliver steatosis[J]. FASEB J, 2019,33(7): 8666-8687.
[3] 黎可嘉 . 肌联素对 2 型糖尿病的预测价值 [D]. 重庆：重庆医科大学 ,2018.LI Kejia. Myonectin predicts the development oftype 2 diabetes [D]. Chongqing:Chongqing MedicalUniversity,2018.
[4] SELDIN M M, LEI Xia, TAN S Y, et al. Skeletal mus-cle-derived myonectin activates the mammalian targetof rapamycin (mTOR) pathway to suppress autophagyin liver[J]. J Biol Chem. 2013; 288(50):36073-36082.
[5] PARK S Y, CHOI J H, RYU H S, et al. C1q tumornecrosis factor α-related protein isoform 5 is increasedin mitochondrial DNA-depleted myocytes and activatesAMP-activated protein kinase[J]. J Biol Chem. 2009,284(41):27780-27789.
[6] 魏代敏 , 张真真 , 王泽 , 等 . 高雄激素对多囊卵巢综合征患者辅助生殖治疗妊娠后产科并发症的影响[J]. 中华妇产科杂志 , 2018, 53(1):18-22.WEI Daimin, ZHANG Zhenzhen, WANG Ze, et al.Effect of hyperandrogenism of singleton pregnancyfrom in vitro fertilization in women with polycysticovary syndrome [J].Chinese Journal of Obstetrics andGynecology, 2018, 53(1):18-22.
[7] 杜静 , 李佳丽 , 晏耀明 , 等 . 多囊卵巢综合征患者血清 AMH,LH 和 FSH 水平检测及临床应用研究 [J].现代检验医学杂志 ,2019,34(5):68-71.DU Jing, LI Jiali, YAN Yaoming, et al.Detection andclinical application of serum AMH, FSH and LH inpatients with polycystic ovaryian syndrome [J].JModern Laboratory Medicine, ,2019,34(5):68-71.
[8] 李丽春 , 张红莉 , 南刚 . 多囊卵巢综合征患者血清IL-23 水平的检测及临床意义 [J]. 现代检验医学杂志 ,2017, 32(5):108-109, 114.LI Lichun, ZHANG Hongli, NAN Gang.Clinicalsignificance of serum IL-23 level in patients withpolycystic ovary syndrome(PCOS) [J].Journal ofModern Laboratory Medicine, 2017,32(5):108-109,114.
[9] 袁利 , 程明刚 , 刘香萍 , 等 . 深圳地区健康育龄妇女血清中 AMH 水平现况及其在 PCOS 和 POF 诊疗中的价值 [J]. 现代检验医学杂志 ,2017,32(5):141-144.YUAN Li, CHENG Minggang, LIU Xiangping, etal.Status of AMH in serum of healthy women agein Shenzhen area and its value in the diagnosis andtreatment of PCOS and POF treatment[J].Journal ofModern Laboratory Medicine,2017,32(5):141-144.
[10] 毛维维 , 伊桂叶 . 不同肥胖类型患者血清代谢指标与内脏脂肪指数的相关性分析 [J]. 现代检验医学杂志 , 2019,34(5):1-3,8.MAO Weiwei, Yi Guiye. Correlation adiposity betweenserum metabolic indexes and different obesity typesvisceral adiposity index of [J].J Modern LaboratoryMedicine, 2019,34(5):1-3, 8.
[11] 马清光 , 李慧敏 , 程晓超 , 等 . 超重孕妇肥胖抑制素、炎症因子水平及相关性研究 [J]. 现代检验医学杂志 ,2018,33（6）:65-68.MA Qing-guang, LI Hui-min, CHENG Xiao, et al.Studyon the correlation between obestatin and inflammatoryfactors in prepregnancy overweight women [J]. Journalof Modern Laboratory Medicine,2018,33(6):65-68.
[12] 莫 军 , 杨 丽 珍 , 李 景 , 等 . 化 学 发 光 法 检 测 妇女血清睾酮及其临床应用 [J]. 现代检验医学杂志 ,2007,22(2):105-106.MO Jun, YANG Lizhen, LI Jing, et al. Chemilumines-cence assay of serum testosterone in women and itsclinical application[J]. Journal of Modern LaboratoryMedicine,2007,22(2):105-106.

相似文献/References:

[1]钟社兰,李功娟,樊阳阳,等.多囊卵巢综合征患者血清中Neudesin水平及其与多项生理生化指标的相关性分析[J].现代检验医学杂志,2021,36(02):98.[doi:doi:10.3969/j.issn.1671-7414.2021.02.023]
　ZHONG She-lan,LI Gong-juan,FAN Yang-yang,et al.Correlation Analysis of Serum Neudesin Level and Multiple Physiological and Biochemical Indexes in Patients with Polycystic Ovarian Syndrome[J].Journal of Modern Laboratory Medicine,2021,36(06):98.[doi:doi:10.3969/j.issn.1671-7414.2021.02.023]
[2]曹阳阳,樊阳阳,宋秀英,等.多囊卵巢综合征患者血清镍纹样蛋白水平检测的临床意义及与实验室指标的相关性研究[J].现代检验医学杂志,2021,36(02):111.[doi:doi:10.3969/j.issn.1671-7414.2021.02.026]
　CAO Yang-yang,FAN Yang-yang,SONG Xiu-ying,et al.Clinical Significance of Serum Metrnl Protein Level Detection in Patients with Polycystic Ovary Syndrome and Its Correlation with Laboratory Indexes[J].Journal of Modern Laboratory Medicine,2021,36(06):111.[doi:doi:10.3969/j.issn.1671-7414.2021.02.026]
[3]宋秀英,樊阳阳,赵　莉,等.多囊卵巢综合征患者血清 Spexin 水平表达及其与多项生理生化指标的相关性分析[J].现代检验医学杂志,2021,36(03):80.[doi:10.3969/j.issn.1671-7414.2021.03.018]
　SONG Xiu-ying,ZHAO Li,CAO Yang-yang,et al.Expression of Serum Spexin in Patients with Polycystic Ovary Syndrome andIts Correlation with Multiple Physiological and Biochemical Indexes[J].Journal of Modern Laboratory Medicine,2021,36(06):80.[doi:10.3969/j.issn.1671-7414.2021.03.018]
[4]林延润a,邱伟全b,彭学博,等.多囊卵巢综合征患者血清性激素水平与胰岛素释放峰值后移的相关性研究[J].现代检验医学杂志,2021,36(06):143.[doi:10.3969/j.issn.1671-7414.2021.06.031]
　LIN Yan-run,PENG Xue-bo,QIU Wei-quan,et al.Study on the Relationship between Serum Sex Hormone Level and Insulin Release Peak Shift in Patients with Polycystic Ovary Syndrome[J].Journal of Modern Laboratory Medicine,2021,36(06):143.[doi:10.3969/j.issn.1671-7414.2021.06.031]
[5]朱 琳,林延润,杨发达,等.PCOS 患者胰岛素释放试验峰值后移与胰岛素分泌总量及敏感性的特征分析[J].现代检验医学杂志,2022,37(05):154.[doi:10.3969/j.issn.1671-7414.2022.05.030]
　ZHU Lin,LIN Yan-run,YANG Fa-da,et al.Analysis of the Relationship between the Peak Shift of Insulin Release Test and Total Insulin Secretion and Sensitivity in Patients with PCOS[J].Journal of Modern Laboratory Medicine,2022,37(06):154.[doi:10.3969/j.issn.1671-7414.2022.05.030]
[6]鲁 霞,曹党恩,李晓兰.多囊卵巢综合征患者血清GnSAF, Irisin, Copeptin 表达水平及其与妊娠结局的相关性研究[J].现代检验医学杂志,2022,37(06):34.[doi:10.3969/j.issn.1671-7414.2022.06.007]
　LU Xia,CAO Dang-en,LI Xiao-lan.Changes of Serum GnSAF, Irisin and Copeptin Levels in Patients with Polycystic Ovary Syndrome and Their Relationship with Pregnancy Outcomes[J].Journal of Modern Laboratory Medicine,2022,37(06):34.[doi:10.3969/j.issn.1671-7414.2022.06.007]
[7]朱 琳,陈跃瑜,林延润,等.PCOS 患者MTHFR C677T 基因多态性与胰岛素峰值后移的相关性研究[J].现代检验医学杂志,2023,38(06):54.[doi:10.3969/j.issn.1671-7414.2023.06.010]
　ZHU Lin,CHEN Yueyu,LIN Yanrun,et al.Relationship between MTHFR C677T Polymorphism and Insulin Peak Shift in Patients with PCOS[J].Journal of Modern Laboratory Medicine,2023,38(06):54.[doi:10.3969/j.issn.1671-7414.2023.06.010]
[8]古丽胡马尔·艾尼瓦尔,吐比克孜·依比力,苏比努尔·买买提,等.多囊卵巢综合征患者血清IL-36α，CTRP6水平表达与临床诊断价值研究[J].现代检验医学杂志,2024,39(06):119.[doi:10.3969/j.issn.1671-7414.2024.06.020]
　GULIHUMAER Ainiwaer,TUBIKEIZ ribili,SUBINUER Maimaiti,et al.Study on the Expression of Serum IL-36α and CTRP6 in Patients with Polycystic Ovary Syndrome and Their Clinical Diagnostic Value[J].Journal of Modern Laboratory Medicine,2024,39(06):119.[doi:10.3969/j.issn.1671-7414.2024.06.020]

更新日期/Last Update: 2020-12-20