[1]任丽芬,张志平,徐　蓓,等.孕妇葡萄糖耐量和血清胰岛素及 C- 肽释放水平检测对妊娠糖尿病的诊断研究[J].现代检验医学杂志,2020,35(06):167-170.[doi:doi:10.3969/j.issn.1671-7414.2020.06.041]
　REN Li-fen,ZHANG Zhi-ping,XU Bei,et al.Study on Diagnosis of Gestational Diabetes Mellitus by Detection of GlucoseTolerance, Serum Insulin and C-peptide Release Levels in Pregnant Women[J].Journal of Modern Laboratory Medicine,2020,35(06):167-170.[doi:doi:10.3969/j.issn.1671-7414.2020.06.041]
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孕妇葡萄糖耐量和血清胰岛素及 C- 肽释放水平检测对妊娠糖尿病的诊断研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年06期
页码:
167-170
栏目:
检验与临床
出版日期:
2020-12-30

文章信息/Info

Title:
Study on Diagnosis of Gestational Diabetes Mellitus by Detection of GlucoseTolerance, Serum Insulin and C-peptide Release Levels in Pregnant Women
文章编号:
1671-7414（2020）06-167-04
作者:
任丽芬1; 张志平1 ; 徐　蓓1 ; 陈建康1 ; 黄晓燕2
（1. 空军军医大学西京医院检验科，西安 710032；2 . 陕西省人民医院中心实验室，西安 710068）
Author(s):
REN Li-fen 1 ;  ZHANG Zhi-ping 1 ; XU Bei 1 ;  CHEN Jian-kang 1 ;  HUANG Xiao-yan 2
(1.Department of Clinical Laboratory, Xijing Hospital Affiliated to the Air Force Medical University, Xi’an 710032，China;2.Central Laboratory of Shaanxi Provincial People’s Hospital, Xi’an 710068,China)
关键词:
孕妇; 葡萄糖耐量; 胰岛素; C 肽; 胰岛素抵抗
分类号:
R714.256；R446.112
DOI:
doi:10.3969/j.issn.1671-7414.2020.06.041
文献标志码:
A
摘要:
目的　研究孕妇葡萄糖耐量试验（ oral glucose tolerance test，OGTT）、胰岛素、C- 肽释放曲线特点，探讨其对妊娠糖尿病（gestational diabetes mellitus ,GDM）的诊断价值。方法　选取 2017 年 12 月～ 2019 年 6 月在西京医院进行产前检查的孕妇 420 例，平均年龄 30.6±4.5 岁，根据 OGTT 测定结果将妊娠妇女分为妊娠糖尿病 (GDM) 组 55 例，正常妊娠者（对照组）365例。分析各组OGTT、胰岛素和C-肽释放曲线特点，比较各组胰岛素抵抗和胰岛分泌功能情况。结果　① GDM 组空腹、1h 和 2h 血糖水平高于对照组 (t=5.599, 19.253, 5.486, 均 P<0.05)，3h 血糖水平与对照组比较，差异无统计学意义（t=1.543，P>0.05）； GDM 组和对照组空腹胰岛素、C 肽水平比较差异无统计学意义（t=1.698，2.12，均 P>0.05），1h，2h 和 3h 胰岛素和 C 肽水平高于对照组（t=2.662~6.909，均 P<0.05）。胰岛素抵抗程度（HOMA-IR）GDM 组高于对照组（t=2.2，P<0.05）；胰岛分泌功能（HOMA-β）GDM 组低于对照组（t=2.235, P<0.05）。②约 17.8% 的孕妇糖耐量曲线、胰岛素释放曲线及 C 肽释放曲线呈“N 字型”，3h 血糖、胰岛素及 C 肽未恢复至正常水平。③GDM孕妇胰岛素、C肽释放出现峰值延迟。结论　OGTT正常孕妇中有部分存在N字形双峰，胰岛素和C肽峰值后移，表明存在胰岛功能受损；GDM 孕妇较正常孕妇胰岛素抵抗更严重，同时有胰岛 β 细胞功能受损。

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更新日期/Last Update: 2020-12-20