[1]王秋云,严　敏,程　珍,等.肿瘤及血液病患者血清 sTRAIL表达及与 IL-6和 Hepcidin水平的相关性研究[J].现代检验医学杂志,2021,36(01):58-60.[doi:10.3969/j.issn.1671-7414.2021.01.015]
　WANG Qiu-yun,YAN Min,CHENG Zhen,et al.Study of the Expression of the Serum sTRAIL, and Its Correlation with Levels of Serum IL-6 and Hepcidin in the Patients with the Tumor and Hematological Diseases[J].Journal of Modern Laboratory Medicine,2021,36(01):58-60.[doi:10.3969/j.issn.1671-7414.2021.01.015]
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肿瘤及血液病患者血清 sTRAIL表达及与 IL-6和 Hepcidin水平的相关性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年01期
页码:
58-60
栏目:
论　著
出版日期:
2021-02-05

文章信息/Info

Title:
Study of the Expression of the Serum sTRAIL, and Its Correlation with Levels of Serum IL-6 and Hepcidin in the Patients with the Tumor and Hematological Diseases
文章编号:
1671-7414（2021）01-058-04
作者:
王秋云; 严　敏; 程　珍; 等
（苏州大学附属太仓医院，江苏苏州 215400）
Author(s):
WANG Qiu-yun;  YAN Min;  CHENG Zhen;  et al
(Taicang Hospital Affiliated to Suzhou University, Jiangsu Suzhou 215400,China)
关键词:
肿瘤; 血液病; 可溶性肿瘤坏死因子相关凋亡诱导配体; 白介素 -6; 铁调素
分类号:
R730.43
DOI:
10.3969/j.issn.1671-7414.2021.01.015
文献标志码:
A
摘要:
目的　研究肿瘤及血液病患者血清可溶性肿瘤坏死因子相关凋亡诱导配体（ sTRAIL）表达，以及与白介素 -6（IL-6）和铁调素（ Hepc）表达的相关性及临床意义。方法　2018年 8月 ~2019年 6月住院患者 34例 (18例肿瘤和 16例血液病 )及 17例健康志愿者分别应用酶联免疫吸附法检测血清 sTRAIL和 Hepc，应用电化学发光法检测血清 IL-6和 SF，并分析其表达特点和相关关系。结果　①肿瘤组和血液病组的 sTRAIL水平分别为 357.97±101.9 pg/ml和 297.44±78.7pg/ml，均明显高于对照组的 150.74±43.1pg/ml（F=31.53，P<0.01）；Hepc分别为 61.16±19.6 μg/L和 67.54±19.5μg/L，均明显高于对照组的 34.78±11.9μg/L（F=16.74，P<0.01）；IL-6分别为 4.60±3.14mg/ml和 12.49±11.69mg/ml，均明显高于对照组的 1.66±0.28mg/ml（F=5.69，P<0.01）。②肿瘤组和血液病组的 Hb分别为 112.72±20.4g/L和 76.31±27.4g/L，均明显低于对照组的 138.00±10.5g/L（F=37.71， P<0.01）；而 SF分别为 530.5±381.91 ng/ml和 807.44±543.1 ng/ml，均明显高于对照组的 104.06±112.2 ng/ml（F=14.10，P<0.01）。③ 51例研究对象的 Hb与 SF，Hepc及 sTRAIL水平均呈负相关（ r=-0.487，-0.379和 -0.308，均 P<0.05）。④ SF与 Hepc和 sTRAIL呈正相关（ r=0.350，0.544，均 P<0.01），sTRAIL与 Hepc呈正相关（ r=0.321， P<0.05）。结论　肿瘤及血液病患者血清 sTRAIL高表达， sTRAIL与 Hepc和 IL-6均呈正相关。 sTRAIL对肿瘤和血液病患者的 Hb水平有负调控作用。

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备注/Memo

备注/Memo:
作者简介：王秋云（1994-），女，苏州大学 2018级血液学专业在读硕士研究生，主要从事血液病的基础与临床研究。
通讯作者：潘湘涛，男，医学博士，主任医师，E-mail: panxiangtao@csco.ac.cn。
更新日期/Last Update: 2021-02-05