[1]钟社兰,李功娟,樊阳阳,等.多囊卵巢综合征患者血清中Neudesin水平及其与多项生理生化指标的相关性分析[J].现代检验医学杂志,2021,36(02):98-100.[doi:doi:10.3969/j.issn.1671-7414.2021.02.023]
 ZHONG She-lan,LI Gong-juan,FAN Yang-yang,et al.Correlation Analysis of Serum Neudesin Level and Multiple Physiological and Biochemical Indexes in Patients with Polycystic Ovarian Syndrome[J].Journal of Modern Laboratory Medicine,2021,36(02):98-100.[doi:doi:10.3969/j.issn.1671-7414.2021.02.023]
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多囊卵巢综合征患者血清中Neudesin水平及其与多项生理生化指标的相关性分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年02期
页码:
98-100
栏目:
论 著
出版日期:
2021-04-30

文章信息/Info

Title:
Correlation Analysis of Serum Neudesin Level and Multiple Physiological and Biochemical Indexes in Patients with Polycystic Ovarian Syndrome
文章编号:
1671-7414(2021)02-098-04
作者:
钟社兰李功娟樊阳阳
(1.安康市人民医院妇产科, 陕西安康 725000;2. 安康市汉滨区第一人民医院妇科,陕西安康 725000;3.陕西省人民医院产科,西安710068)
Author(s):
ZHONG She-lan LI Gong-juan FAN Yang-yang et al
(1.Department of Obstetrics and Gynecology, Ankang People’s Hospital, Shaanxi Ankang 725000, China;2. Department of Gynecology, the First People’s Hospital of Ankang Hanbin District, Shaanxi Ankang 725000, China;3.Department of Obstetrics, Shaanxi Provincial People’s Hospital, Xi’an 710068, China)
关键词:
多囊卵巢综合征生理指标生化指标身体质量指数
分类号:
R711.75;R446.11
DOI:
doi:10.3969/j.issn.1671-7414.2021.02.023
文献标志码:
A
摘要:
目的 探究多囊卵巢综合征(polycystic ovarian syndrome, PCOS)患者血清中Neudesin的水平及其与多项生理生化指标的相关性分析。方法 选取2018年9月至2019年10月安康市人民医院收治的53例PCOS患者为观察组,另选取同期50例体检健康女性为对照组。通过酶联免疫吸附测定法(ELISA)检测血清中Neudesin水平,电化学发光免疫分析法(ECLIA)检测血清卵泡刺激素(follicle-stimulating hormone, FSH)水平。结果 两组超敏C反应蛋白(high-sensitivity C-reactive protein, hs-CRP)和Neudesin水平比较差异具有统计学意义(t=11.63,12.69,均P<0.001),并且观察组的hs-CRP水平高于对照组(1.33±0.42mg/L vs 0.50±0.21mg/L),而观察组的Neudesin水平低于对照组(4.13±1.65ng/ml vs 6.83±2.19ng/ml)。Spearson相关性检验显示Neudesin与平均年龄、空腹血糖(fasting blood-glucose, FBG)、总胆固醇(total cholesterol, TC)、低密度脂蛋白胆固醇(low density lipoprotein cholesterin, LDL-C)、hs-CRP和FSH无显著相关性,而与身体质量指数(body mass index, BMI)呈显著负相关关系(r=-0.24,P=0.01)。结论 PCOS患者血清中Neudesin水平较低并且其受BMI的影响。

参考文献/References:

[1] KIMURA I, YOSHIOKA M, KONISHI M, et al. Neudesin, a novel secreted protein with a unique primary structure and neurotrophic activity[J]. Journal of Neuroscience Research, 2005, 79(3): 287-294.
[2] OHTA H, KIMURA I, KONISHI M, et al.Neudesin as a unique secreted protein with multi-functional roles in neural functions, energy metabolism, and tumorigenesis.[J]. Frontiers in Molecular Biosciences, 2015, 2:24.
[3] BYERLY M S, SWANSON R D, SEMSARZADEH N N, et al. Identification of hypothalamic neuron-derived neurotrophic factor as a novel factor modulating appetite[J]. American Journal of Physiology-Regulatory Integrative and Comparative Physiology, 2013, 304(12): R1085-R1095.
[4] BOZKAYA G, FENERCIOGLU O, DEMIR I, et al.Neudesin: a neuropeptide hormone decreased in subjects with polycystic ovary syndrome[J]. Gynecological Endocrinology, 2020, 36(10): 849-853.
[5] 魏代敏, 张真真, 王泽, 等.高雄激素对多囊卵巢综合征患者辅助生殖治疗妊娠后产科并发症的影响[J].中华妇产科杂志, 2018, 53(1):18-22. WEI Daimin, ZHANG Zhenzhen, WANG Ze, et al. Effect of hyperandrogenism on obstetric complications of singleton pregnancy from in vitro fertilization in women with polycystic ovary syndrome[J]. Chinese Journal of Obstetrics and Gynecology, 2018, 53(1):18-22.
[6] 杜静, 李嘉丽, 晏耀明, 等.多囊卵巢综合征患者血清AMH,LH和FSH水平检测及临床应用研究[J].现代检验医学杂志, 2019,34(5):68-71.. DU Jing, LI Jiali, YAN Yaoming, et al. Detection and clinical application of serum AMH,FSH and LH in patients with polycystic ovarian syndrome[J]. Journal of Modern Laboratory Medicine, 2019,34(5):68-71.
[7] 袁利, 程明刚, 刘香萍, 等.深圳地区健康育龄妇女血清中AMH水平现况及其在PCOS和POF诊疗中的价值[J].现代检验医学杂志,2017,32(5):141-144. YUAN Li, CHENG Minggang, LIU Xiangping, et al. Status of AMH in serum of healthy women in Shenzhen area and its value in PCOS and POF treatment [J]. Journal of Modern Laboratory Medicine,2017,32(5):141-144.
[8] 马清光, 李慧敏, 程晓, 等.超重孕妇肥胖抑制素、炎症因子水平及相关性研究[J].现代检验医学杂志, 2018, 33(6):65-68. MA Qingguang, LI Huimin, CHENG Xiao, et al. Study on the Correlation between obestatin and inflammatory factors in prepregnancy overweight women[J]. Journal of Modern Laboratory Medicine, 2018, 33(6):65-68.
[9] 马志慧.病毒性肝炎常见的化验指标及其临床意义分析[J].中国医药指南,2013,11(14):627-628. MA Zhihui. Virual hepatitis common laboratory indexes and their clinical significance[J]. Guide of China Medicine, 2013,11(14):627-628.
[10] 李丽春,张红莉,南刚.多囊卵巢综合征患者血清IL-23水平的检测及临床意义[J].现代检验医学杂志, 2017,32(5):108-109,114. LI Lichun, ZHANG Hongli, NAN Gang. Clinical significance of serum IL-23 levels in patients with polycystic ovary syndrome(PCOS)[J].Journal of Modern Laboratory Medicine, 2017,32(5):108-109,114.
[11] 莫军, 杨丽珍, 李景, 等.化学发光法检测妇女血清睾酮及其临床应用[J].现代检验医学杂志,2007,22(2):105-106. MO Jun, YANG Lizhen, LI Jing, et al. Chemiluminescence assay of serum testosterone in women and its clinical application[J]. Journal of Modern Laboratory Medicine,2007,22(2):105-106.
[12] 辛铭, 孟高乐, 王琦, 等.Hp感染消化性溃疡患者血清GAS,hs-CRP及TGF-α水平检测及其临床意义[J].中国实验诊断学,2020,24(10):1671-1672. XIN Ming, MENG Gaole, WANG Qi, et al. Detection of serum GAS, HS-CRP and TGF- levels in patients with Hp infection with peptic ulcer and its clinical significance[J]. Chinese Journal of Laboratory Diagnosis, 2020,24(10):1671-1672.
[13] 杨莉婷,陈翠,蒋兴亮.2型糖尿病患者血清残余胆固醇水平与超敏C反应蛋白表达的相关性研究[J].现代检验医学杂志,2020,35(4):45-49. YANG Liting, CHEN Cui, JIANG Xingliang. Association between serum remnant cholesterol levels and expression of high sensitive C-reactive protein in patients with type 2 diabetes mellitus [J]. Journal of Modern Laboratory Medicine, 2020,35(4):45-49.

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备注/Memo

备注/Memo:
作者简介:钟社兰(1986-),女,本科,主治医师,研究方向:妇科内分泌,E-mail:ankangzhongshel@163.com。
通讯作者:王许锐(1989-),女,本科,住院医师,研究方向:妇科内分泌,E-mail:821487317@qq.com。
更新日期/Last Update: 2021-04-10