[1]高　伟,席　锐,李　涛.血清C-反应蛋白和内皮素水平检测与急性胆囊炎临床分级的相关性分析[J].现代检验医学杂志,2021,36(02):144-147.[doi:doi:10.3969/j.issn.1671-7414.2021.02.034]
　GAO Wei,XI Rui,LI Tao.Correlation Analysis of Serum C-reactive Protein and Endothelin Levels with Clinical Grade of Acute Cholecystitis[J].Journal of Modern Laboratory Medicine,2021,36(02):144-147.[doi:doi:10.3969/j.issn.1671-7414.2021.02.034]
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血清C-反应蛋白和内皮素水平检测与急性胆囊炎临床分级的相关性分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年02期
页码:
144-147
栏目:
检验与临床
出版日期:
2021-04-30

文章信息/Info

Title:
Correlation Analysis of Serum C-reactive Protein and Endothelin Levels with Clinical Grade of Acute Cholecystitis
文章编号:
1671-7414（2021）02-144-04
作者:
高　伟; 席　锐; 李　涛
(汉中市中心医院肝胆外科，陕西汉中 723000)
Author(s):
GAO Wei;  XI Rui;  LI Tao
(Department of Hepatobiliary Surgery, Hanzhong Central Hospital, Shaanxi Hanzhong 723000, China)
关键词:
急性胆囊炎; C-反应蛋白; 内皮素
分类号:
R576；R446.11
DOI:
doi:10.3969/j.issn.1671-7414.2021.02.034
文献标志码:
A
摘要:
目的　探究血清C-反应蛋白(C-reactive protein, CRP)、内皮素(endothelin, ET)水平检测与急性胆囊炎(acute cholecystitis, AC)临床分级的相关性。方法　选取汉中市中心医院2017年3月～2019年11月收治的110例AC患者为观察组，另选取同期110例健康体检者为对照组，分别收集两组的吸烟、饮酒、高血压、CRP和ET水平等一般资料。采用酶联免疫吸附测定法(ELISA)检测人血清中CRP水平，采用放射免疫法(radioimmunoassay, RIA)检测人血清中ET水平。采用Spearson相关性检验分析CRP，ET联合与AC临床分级的相关性。结果　两组的性别、平均年龄、吸烟、饮酒、高血压、糖尿病差异均无统计学意义(χ2/t=1.640，0.428，3.160，4.250，3.570，3.660，均P＞0.05)。两组的CRP和ET水平差异具有统计学意义(t=9.629，7.374，均P＜0.05)，且观察组患者的CRP和ET水平显著高于对照组。ROC曲线分析CRP，ET和二者联合诊断AC的曲线下面积(AUC)分别是0.843 (95% CI: 0.771～0.916，P=0.000)，0.772 (95% CI:0.683～0.860，P=0.000)和0.910 (95% CI:0.851～0.969，P=0.000)，约登指数最大值对应的CRP，ET为诊断AC的最佳截距值(cut-off)分别是8.2 mg/L和72.5 pg/ml，CRP与ET联合诊断AC的灵敏度，特异度均高于单独使用CRP和ET。CRP，ET联合与AC分级呈正相关关系(r=0.386，P＜0.05)。结论　CRP和ET联合水平可区分不同严重程度的AC。CRP，ET联合与AC分级呈正相关关系，值得深入研究和应用。

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备注/Memo

备注/Memo:
作者简介：高伟（1979-），男，硕士，副主任医师，研究方向：肝胆外科疾病的防治，E-mail:Gaowei05235@sohu.com。
更新日期/Last Update: 2021-04-10