[1]杨 瑜,薛 伟,孔 维.腔隙性脑梗死患者血清 Lp-PLA2 及 MIF 水平与认知功能障碍的相关性研究[J].现代检验医学杂志,2021,36(03):132-136.[doi:10.3969/j.issn.1671-7414.2021.03.030]
 YANG Yua,XUE Weib,KONG Weic.Correlation between the Levels of Lp-PLA2 and MIF in Serum andCognitive Dysfunction in Patients with Lacunar Infarction[J].Journal of Modern Laboratory Medicine,2021,36(03):132-136.[doi:10.3969/j.issn.1671-7414.2021.03.030]
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腔隙性脑梗死患者血清 Lp-PLA2 及 MIF 水平与认知功能障碍的相关性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年03期
页码:
132-136
栏目:
检验与临床
出版日期:
2021-05-31

文章信息/Info

Title:
Correlation between the Levels of Lp-PLA2 and MIF in Serum andCognitive Dysfunction in Patients with Lacunar Infarction
文章编号:
1671-7414(2021)03-132-05
作者:
杨 瑜薛 伟孔 维
( 咸阳市第一人民医院 a. 检验科;b. 输血科;c. 神经内科 , 陕西咸阳 712000)
Author(s):
YANG Yua XUE WeibKONG Weic
(a.Department of Clinical Laboratory;b.Department of Blood Transfusion;c.Department of Neurology, the First People’s Hospital of Xianyang City, Shaanxi Xianyang 712000, China)
关键词:
腔隙性脑梗死认知功能障碍脂蛋白相关磷脂酶 A2巨噬细胞游走抑制因子蒙特利尔认知功能评估颈动脉内膜中层厚度
分类号:
R743.33;R392.11
DOI:
10.3969/j.issn.1671-7414.2021.03.030
文献标志码:
A
摘要:
目的 探讨血清脂蛋白相关磷脂酶 A2(lipoprotein-associated phospholipase A2,Lp-PLA2) 及巨噬细胞游走抑制因子 (macrophage migration inhibitory factor,MIF) 水平与腔隙性脑梗死 (lacunar infarction,LI) 患者认知功能障碍的相关性。方法 收集 2018 年 3 月 ~2020 年 3 月期间在咸阳市第一人民医院就诊的 90 例 LI 患者的临床资料进行回顾性分析 , 依据患者是否有认知功能障碍将其分为认知功能正常组 ( 正常组 47 例 ) 和认知功能障碍组 ( 障碍组 43 例 )。另选取 45 例同期体检健康者作为对照组。采用酶联免疫吸附法检测血清 Lp-PLA2 及 MIF 水平。所有研究对象均接受蒙特利尔认知功能评估 (Montreal Cognitive Assessment,MoCA) 以及颈动脉超声检查 , 通过彩色多普勒超声诊断仪获得所有研究对象的颈动脉内膜中层厚度 (carotid intima-media thickness,CIMT)。比较分析以上指标的变化与 LI 患者认知功能障碍的相关性。结果 对照组、正常组和障碍组的血清 Lp-PLA2 和 MIF 水平分别为 (8.63±2.79, 17.26±3.93,25.67±5.03μg/L 和60.17±11.29, 83.35±15.30,105.28±20.19ng/ml)。与对照组比较 , 正常组和障碍组的 Lp-PLA2 和 MIF 水平明显增高 ,且障碍组增高更显著 (F=16.068~33.693,均 P=0.000)。相关性分析显示 , 正常组和障碍组的血清 Lp-PLA2 和 MIF 水平分别呈正相关性(r=0.826,0.850,均P<0.01)。正常组的MIF及Lp-PLA2分别与MoCA评分及CIMT呈正相关性(rMIF=0.809,0.816, 均 P<0.01;rLp-PLA2=0.789,0.802, 均 P<0.01),障碍组的 MIF 及 Lp-PLA2 水平分别与 MoCA 评分及 CIMT 呈正相关性(rMIF=0.830,0.842,P 均 <0.01;rLp-PLA2=0.828,0.835, 均 P<0.01)。结论 Lp-PLA2 及 MIF 与 LI 患者认知功能障碍的发生相关。检测血清 Lp-PLA2 及 MIF 水平可评估 LI 的进展并预测 LI 的预后,其差异性的变化可以反映 LI 患者认知功能障碍发展过程。

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备注/Memo

备注/Memo:
作者简介:杨瑜(1984-),女,本科,主管检验师,研究方向:脑卒中标志物的研究,E-mail:1357606542@qq.com。
通讯作者:薛伟(1967-),男,本科,副主任检验师,研究方向:脑卒中标志物的研究,E-mail:2191487760@qq.com。
更新日期/Last Update: 1900-01-01