[1]张　珍,王新庄.脓毒症患者血清 YKL-40 水平检测与急性肾损伤早期诊断的相关性研究[J].现代检验医学杂志,2021,36(03):148-150.[doi:10.3969/j.issn.1671-7414.2021.03.034]
　ZHANG Zhen,WANG Xin-zhuang.Correlation between Serum YKL-40 Level and Early Diagnosis of AcuteKidney Injury in Patients with Sepsis[J].Journal of Modern Laboratory Medicine,2021,36(03):148-150.[doi:10.3969/j.issn.1671-7414.2021.03.034]
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脓毒症患者血清 YKL-40 水平检测与急性肾损伤早期诊断的相关性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年03期
页码:
148-150
栏目:
检验与临床
出版日期:
2021-05-31

文章信息/Info

Title:
Correlation between Serum YKL-40 Level and Early Diagnosis of AcuteKidney Injury in Patients with Sepsis
文章编号:
1671-7414（2021）03-148-03
作者:
张　珍; 王新庄
( 西安高新医院急诊科，西安 710075)
Author(s):
ZHANG Zhen;  WANG Xin-zhuang
（Department of Emergency, Xi’an Gaoxin Hospital, Xi ’an 710075, China）
关键词:
脓毒症; 人类软骨糖蛋白 39（YKL-40）; 急性肾损伤
分类号:
R631；R691.6；R392.11
DOI:
10.3969/j.issn.1671-7414.2021.03.034
文献标志码:
A
摘要:
目的　探究脓毒症患者血清人类软骨糖蛋白 -39(YKL-40) 水平检测与急性肾损伤 (acute kidney injury, AKI) 早期诊断的相关性研究。方法　选择 2018 年 7 月～ 2020 年 2 月西安高新医院急诊科收治的 170 例脓毒症患者为研究对象，根据患者入住 ICU 后 24 h 内是否发生 AKI 分为 AKI 组和非 AKI 组。采用酶联免疫吸附法 (ELISA) 检测血清 YKL40 的水平。结果 AKI 组和非 AKI 组的平均年龄、吸烟史、饮酒史、白细胞计数 (white blood cell count, WBC) 比较差异均无统计学意义 (t=0.37,χ2=1.71,χ2=0.90,t=0.67, 均 P ＞ 0.05)，AKI 组的血肌酐 (serum creatinine, SCr) 和 YKL-40 水平均高于非 AKI 组，其差异均有统计学意义 (χ2=5.97，10.11，均 P ＜ 0.05)。脓毒症伴 AKI- Ⅲ期患者血清 YKL-40 水平高于脓毒症伴 AKI- Ⅱ期和 AKI- Ⅰ期，脓毒症伴 AKI- Ⅱ期显著高于 AKI- Ⅰ期，其组间差异具有统计学意义 (F=1.37，P=0.00)。Pearson 相关法分析结果显示，血清 YKL-40 水平与 SCr 和 AKI 分期呈正相关关系 (r= 0.19，0.25，P=0.00)。ROC 曲线分析结果显示，区别诊断 AKI 及非 AKI 患者时，血清 YKL-40 的 AUC 为 0.88(95%CI 0.81~0.94)，当 cut-off值为 4.20 ng/mg 时，特异度和灵敏度分别为 0.75 和 0.78。区别诊断脓毒症伴 AKI- Ⅲ期与 AKI-Ⅰ/Ⅱ期患者时，血清YKL-40 的 AUC 为 0.82(95%CI 0.71~0.94)，当 cut-off 值为 6.79 ng/mg 时，特异度和灵敏度分别为 0.83 和 0.72。结论血清 YKL-40 在脓毒症伴 AKI 患者中高表达，可用于诊断 AKI 和判断 AKI 的严重程度。

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备注/Memo

备注/Memo:
作者简介：张珍（1987-），女，本科，主治医师，研究方向：急诊科常见疾病的临床诊疗，E-mail:luckzhangzhen@163.com。
通讯作者：王新庄（1980-），男，主治医师，研究方向：急诊科常见疾病的临床治疗，E-mail:838035758@qq.com。
更新日期/Last Update: 1900-01-01