[1]林延润a,邱伟全b,彭学博,等.多囊卵巢综合征患者血清性激素水平与胰岛素释放峰值后移的相关性研究[J].现代检验医学杂志,2021,36(06):143-147.[doi:10.3969/j.issn.1671-7414.2021.06.031]
　LIN Yan-run,PENG Xue-bo,QIU Wei-quan,et al.Study on the Relationship between Serum Sex Hormone Level and Insulin Release Peak Shift in Patients with Polycystic Ovary Syndrome[J].Journal of Modern Laboratory Medicine,2021,36(06):143-147.[doi:10.3969/j.issn.1671-7414.2021.06.031]
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多囊卵巢综合征患者血清性激素水平与胰岛素释放峰值后移的相关性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年06期
页码:
143-147
栏目:
研究简报·实验技术
出版日期:
2021-12-15

文章信息/Info

Title:
Study on the Relationship between Serum Sex Hormone Level and Insulin Release Peak Shift in Patients with Polycystic Ovary Syndrome
文章编号:
1671-7414（2021）06-143-05
作者:
林延润1a; 邱伟全1b; 彭学博2; 朱　琳1a; 杨发达1a; 陈跃瑜1a
（1.佛山市南海区妇幼保健院a.检验科；b.生殖健康科 ，广东佛山 528200；2.广东省中西医结合医院公卫科， 广东佛山 528200）
Author(s):
LIN Yan-run;  PENG Xue-bo;  QIU Wei-quan;  et al
（1a.Department of Clinical Laboratory；1b. Department of Reproductive Medicine, Nanhai District Maternal and Child Health Hospital of Foshan City, Guangdong Foshan 528200, China；2. Department of Public Health, Guangdong TCM and Western Medicine Hospital，Guangdong Foshan 528200，China）
关键词:
多囊卵巢综合征; 性激素; 胰岛素; 峰值后移
分类号:
R711.75；R392.11
DOI:
10.3969/j.issn.1671-7414.2021.06.031
文献标志码:
A
摘要:
目的　探讨多囊卵巢综合征（polycystic ovary syndrome，PCOS）患者血清性激素水平与胰岛素释放峰值后移的相关性。方法　选取2019年11月～2021年1月在佛山市南海区妇幼保健院生殖健康科就诊PCOS患者120例，行胰岛素释放试验（insulin release test，IRT）和血清性激素检测。血清性激素检测包括雌二醇（estradiol,E2）、孕酮(progesterone,PG)、黄体生成素(luteinizing hormone,LH)、卵泡刺激素（follicle stimulating hormone,FSH）、泌乳素（prolactin,PRL）和睾酮（testosterone,T）。根据IRT结果进行分组，峰值时间在30或者60min，纳入无峰值后移组（n=60），峰值时间在120或者180 min，纳入峰值后移组（n=60）。比较两组血清性激素水平的差异，并分析性激素水平与胰岛素释放峰值后移的相关性。结果　峰值后移组血清LH和FSH水平高于无后移组（t=2.369, 2.066, P=0.019，0.041），血清E2峰值后移组低于无后移组(t=2.157，P=0.033)，差异均有统计学意义；两组血清PG，PRL和T比较差异无统计学意义（Z=0.458, P =0.648；t =0.089，P =0.930；t =0.191， P =0.850）。Pearson相关性分析结果表明血清PG，PRL和T与胰岛素释放峰值后移无相关性(r=-0.042，0.008，0.018，均P>0.05)，LH和FSH与胰岛素释放峰值后移呈显著正相关(r=0.213，0.187，均P<0.05)，而E2与胰岛素释放峰值后移呈显著负相关(r=-0.195，P<0.05)。结论　PCOS患者峰值后移与血清E2，LH，FSH存在相关性,可为阐明胰岛素释放峰值后移的机制提供参考依据。
Abstract:
Objective　To investigate the relationship between the serum sex hormone level and the insulin release peak shift in patients with polycystic ovary syndrome（PCOS）. Methods　Insulin release test (IRT) and serum sex hormones were performed in 120 patients with PCOS from November 2019 to January 2021 at the Reproductive Health Department of Nanhai District Maternal and Child Health Hospital in Foshan . The serum sex hormone included estradiol（E2），progesterone (PG), luteinizing hormone (LH)、follicle stimulating hormone（FSH）, prolactin （PRL）and testosterone（T）. The subjects were divided into two groups according to the IRT. Those with a peak time of 30 or 60 minutes were included in the non-peak-shift group (n=60), and those with a peak time of 120 or 180 minutes were included in the peak-shift group (n=60) . The differences of serum sex hormone levels between the two groups were compared and the correlation between sex hormone levels and the backward shift of insulin peak was analyzed. Results　The levels of serum LH and FSH in insulin peak shift group were higher than those in insulin peak non-shift group（t=2.369, 2.066, P=0.019, 0.041）, the levels of serum E2 were lower than those insulin peak non-shift group(t=2.157，P=0.033), and the differences of them were statistically significant, respectively. However, the serum PG, PRL and T of the two groups were not statistically significant（Z=0.458, P =0.648; t =0.089, P =0.930; t =0.191, P =0.850, P>0.05）. Pearson correlation analysis showed that there was no correlation between serum PRL, T, PG and insulin release peak shift( r=-0.042, 0.008, 0.018, all P>0.05) , LH and FSH were positively correlated with insulin release peak shift (r=0.213，0.187, all P<0.05), while E2 was negatively correlated with insulin peak shift(r=-0.195, P<0.05). Conclusion　Serum E2, LH and FSH were related with PCOS patients with insulin release peak shift , this may provide a reference for the determination of insulin peak shift.

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备注/Memo

备注/Memo:
基金项目： 2020年佛山市自筹经费类科技计划项目（医学类科技攻关项目）：多囊卵巢综合征患者性激素水平与胰岛素释放峰值后移的相关性研究，编号：2020001004478。作者简介：林延润（1985-），男，本科，副主任技师，研究方向：产前筛查与产前诊断方向，E-mail: linyanrun@163.com。
更新日期/Last Update: 1900-01-01