[1]于　艳,白青山,才蔚涛.子痫前期并发幽门螺旋杆菌感染患者血清 miR-31-5p表达与不良妊娠结局的相关性研究[J].现代检验医学杂志,2022,37(01):17-20.[doi:10.3969/j.issn.1671-7414.2022.01.004]
　YU Yan,BAI Qing-shan,CAI Wei-tao.Correlation between Serum miR-31-5p Expression and Adverse Pregnancy Outcomes in Patients with Preeclampsia Complicated with Helicobacter Pylori Infection[J].Journal of Modern Laboratory Medicine,2022,37(01):17-20.[doi:10.3969/j.issn.1671-7414.2022.01.004]
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子痫前期并发幽门螺旋杆菌感染患者血清 miR-31-5p表达与不良妊娠结局的相关性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第37卷
期数:
2022年01期
页码:
17-20
栏目:
论　著
出版日期:
2022-01-15

文章信息/Info

Title:
Correlation between Serum miR-31-5p Expression and Adverse Pregnancy Outcomes in Patients with Preeclampsia Complicated with Helicobacter Pylori Infection
文章编号:
1671-7414（2022）01-017-05
作者:
于　艳1; 白青山1; 才蔚涛2
（1. 唐山市妇幼保健院，河北唐山 063000；2. 中国人民解放军联勤保障部队第982 医院，河北唐山 063000）
Author(s):
YU Yan1;  BAI Qing-shan1;  CAI Wei-tao2
（1.Tangshan Maternity and Child Health Hospital, Hebei Tangshan 063000,China; 2.the 982th Hospital of the JointLogistics Support Force of the Chinese People’s Liberation Army, Hebei Tangshan 063000,China）
关键词:
子痫前期; 幽门螺旋杆菌; 微小核糖核酸 -31-5p; 不良妊娠结局
分类号:
R714.255；R392.11
DOI:
10.3969/j.issn.1671-7414.2022.01.004
文献标志码:
A
摘要:
目的　探究血清微小核糖核酸 -31-5p（miR-31-5p）表达与子痫前期（ PE）并发幽门螺旋杆菌（ Hp）感染患者不良妊娠结局的相关性。方法　选取 2019年 1月～ 2020年 5月在唐山市妇幼保健院就诊的 204例 PE并发 Hp感染患者作为研究对象，并根据妊娠结局将其分为不良妊娠组（ n=121）和正常妊娠组（ n=83）。用实时荧光定量 PCR法检测 PE确诊时（ T0）、妊娠 28周第 1天（T1）和妊娠 30周第 1天（T2）的血清 miR-31-5p表达量。结果　不良妊娠组的收缩压、舒张压、24 h尿蛋白和剖宫产率分别为 155.64±11.89mmHg，101.25±6.16mmHg，2.69±0.52g/24 h和 85.95%，均高于正常妊娠组（151.75±11.34mmHg，97.93±8.79mmHg，2.06±0.29g/24 h和 65.06%)；分娩孕周为 34.79±2.06周，低于正常妊娠组（ 37.94±0.97周），差异均有统计学意义（ t/χ2=2.344～ 14.631，均 P<0.05）。不良妊娠组的血清 T0-miR-31-5p，T1-miR-31-5p和 T2-miR-31-5p相对表达量分别为 2.42±0.39，2.20±0.42和 2.10±0.25，均高于正常妊娠组（2.11±0.32，
Abstract:
Objective　To explore the correlation between serum microRNA-31-5p (miR-31-5p) expression and adverse pregnancyoutcomes in patients with preeclampsia (PE) complicated with Helicobacter pylori (Hp). Methods　A total of 204 patients withPE complicated with Hp treated in Tangshan Maternity and Child Health Hospital from January 2019 to May 2020 were selectedas the research objects, divided into the poor pregnancy group (n=121) and the normal pregnancy group (n=83) according to thepregnancy outcome. The expression level of serum miR-31-5p at the time of PE diagnosis (T0), the first day of 28th week ofgestation (T1) and the first day of 30th week of gestation (T2) were detected by real-time quantitative PCR. Results　The systolicblood pressure, diastolic blood pressure, 24 h urinary protein and the rates of cesarean section in the poor pregnancy group were155.64±11.89 mmHg, 101.25±6.16 mmHg, 2.69±0.52 g/24h and 85.95%, respectively, which were higher than those in thenormal pregnancy group (151.75±11.34mmHg, 97.93±8.79mmHg, 2.06±0.29 g/24 h and 65.06%), the gestational perimeter ofdelivery was 34.79±2.06 weeks, which was lower than that of the normal pregnancy group (37.94±0.97) weeks, with statisticallysignificant (t/χ2=2.344~12.302, all P ＜ 0.05). The relative expression levels of serum T0-miR-31-5p, T1-miR-31-5p and T2-miR-31-5p in the poor pregnancy group were 2.42±0.39, 2.20±0.42 and 2.10±0.25, respectively, which were all higher than those inthe normal pregnancy group (2.11±0.32, 1.76±0.33 and 1.69±0.20), with statistically significant (t=6.025~12.657, all P=0.000).The area under the receiver operating characteristic curve of T2-miR-31-5p in predicting pregnancy outcome of patients with PEcomplicated with Hp was higher than that of T0-miR-31-5p and T1-miR-31-5p, with statistically significant (Z=4.957, P=0.000;Z=3.009, P=0.003). Logistic regression analysis showed that high 24 h urine protein (OR=15.250, 95%CI:2.844~81.781), high ratesof cesarean section (OR=7.954, 95%CI:1.416~44.675) and high T2-miR-31-5p (OR=24.479, 95%CI:0.132~0.452) were independentrisk factors for poor pregnancy outcome in patients with PE complicated with Hp, and long gestational perimeter of delivery(OR=0.244, P=0.000) was an independent protective factor for poor pregnancy outcome in patients with PE complicated with Hp.Conclusion　The high expression of serum T2-miR-31-5p is related to the adverse pregnancy outcome of patients with PEcomplicated with Hp.

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备注/Memo

备注/Memo:
基金项目：河北省医学科学研究基金项目（20201487）。
作者简介：于艳（1984-），女，本科，主治医师，主要从事子痫前期的治疗及预后标志物研究，E-mail：y12356yy@163.com。
更新日期/Last Update: 1900-01-01