[1]姜灵路,苟甜甜.四川西部地区表观健康藏族成年人群血清同型半胱氨酸参考区间的建立[J].现代检验医学杂志,2023,38(06):174-177.[doi:10.3969/j.issn.1671-7414.2023.06.032]
　JIANG Linglu,GOU Tiantian.Establishment of A Reference Interval of Serum Homocysteine in An Epilogically Healthy Tibetan Adult Population in Western Sichuan Province[J].Journal of Modern Laboratory Medicine,2023,38(06):174-177.[doi:10.3969/j.issn.1671-7414.2023.06.032]
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四川西部地区表观健康藏族成年人群血清同型半胱氨酸参考区间的建立()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第38卷
期数:
2023年06期
页码:
174-177
栏目:
检验与临床
出版日期:
2023-11-15

文章信息/Info

Title:
Establishment of A Reference Interval of Serum Homocysteine in An Epilogically Healthy Tibetan Adult Population in Western Sichuan Province
文章编号:
1671-7414（2023）06-174-04
作者:
姜灵路; 苟甜甜
（通用医疗三六三医院检验科，成都 610041）
Author(s):
JIANG Linglu; GOU Tiantian
（Department of Clinical Laboratory, Genertec 363 Hospital, Chengdu 610041, China）
关键词:
四川西部地区; 健康藏族成年人群; 血清同型半胱氨酸; 参考区间
分类号:
R446.112
DOI:
10.3969/j.issn.1671-7414.2023.06.032
文献标志码:
A
摘要:
目的 分析四川西部地区表观健康藏族成年人群血清同型半胱氨酸（homocysteine，Hcy）的水平，建立该人群Hcy 的参考区间。方法 纳入2022 年1 ～ 12 月在三六三医院体检的四川西部地区表观健康藏族成年人2 668 例，检测Hcy 水平，按性别和年龄分组，使用Mann-Whitney U 检验分析性别间差异，Kruskal-Wallis H 检验分析各年龄段的组间差异，将各组间差异无统计学意义的数据合并后，以百分位数法建立参考区间。结果 该人群Hcy 水平呈正偏态分布（S=0.946，K=1.55），其水平随年龄增加而升高，且男性高于女性（U＝ 3 759.00 ～ 32 576.00，均P ＜ 0.05）。男性18 ～ 60，60 ～ 70 和＞ 70 岁的参考区间分别为≤ 15.60μmol/L， ≤ 16.88μmol/L 和≤ 18.06μmol/L。女性18 ～ 30，30 ～ 50，50 ～ 60，60 ～ 70 和＞ 70 岁参考区间分别为≤ 13.07μmol/ L，≤ 12.04μmol/ L，≤ 12.87μmol/ L，≤ 15.01μmol/ L 和≤ 16.53μmol/L。结论 四川西部地区表观健康藏族成年人群Hcy 水平受性别和年龄影响，有必要建立适宜当地的参考区间，为心脑血管疾病的诊断及预后提供更精准的参考依据。
Abstract:
Objective To analyze the level of serum homocysteine (Hcy) in apparently healthy Tibetan adults in western Sichuan province was analyzed, and the reference interval of Hcy in this population was established. Methods A total of 2 668 cases of apparent healthy Tibetan adults in western Sichuan province who were examined at the Physical Examination Center of Genertec 363 Hospital in January to December 2022 were included. Hcy levels were tested，group by sex and age, the Mann-Whitney U test was used to analyze the sex differences, and the Kruskal-Wallis H test was used to analyze the groups of different age groups, and the data with no statistical difference between the groups were combined to establish the reference interval by percentile method. Results The Hcy data in this population were positively skewed distribution (S=0.946, K=1.55), and the level of Hcy increased with age, and the Hcy levels in men were higher than women, and the differences were statistically significant (U=3 759.00 ～ 32 576.00, all P ＜ 0.05). The reference intervals for males 18~60, 60 ～ 70, and ＞ 70 years old were ≤ 15.60, ≤ 16.88, and ≤ 18.06μmol/L, respectively. The reference intervals for women aged 18 ～ 30, 30 ～ 50, 50 ～ 60, 60 ～ 70 and ＞ 70 years old were ≤ 13.07, ≤ 12.04, ≤ 12.87, ≤ 15.01, and ≤ 16.53μmol/L, respectively. Conclusion The Hcy level of apparently healthy Tibetan adult population in western Sichuan province was affected by gender and age, so it is necessary to establish a suitable local reference interval to provide a more accurate reference basis for the diagnosis and prognosis of cardiovascular and cerebrovascular diseases.

参考文献/References:

[1] 张愉, 权青云, 孙鹃, 等. 视网膜静脉阻塞患者血清同型半胱氨酸水平检测的临床意义[J]. 现代检验医学杂志, 2018, 33(1): 118-120. ZHANG Yu, QUAN Qingyun, SUN Juan, et al. Clinical observation of the relationship between retinal vein occlusion and homocysteine[J]. Journal of Modern Laboratory Medicine, 2018, 33(1): 118-120.
[2] 曹秀丽. 高同型半胱氨酸血症的触发因素及其病理生理学意义分析[J]. 智慧健康, 2020, 6(15): 47-48. CAO Xiuli. Research on triggering factors and pathophysiologicalsign if icance of hyperhomocysteinemia [J]. Smart Healthcare, 2020,6(15): 47-48.
[3] ZARIC B L, OBRADOVIC M, BAJIC V, et al. Homocysteine and hyperhomocysteinaemia[J]. Current Medicinal Chemistry, 2019, 26(16): 2948-2961.
[4] 房亚哲, 郭楠, 聂庆东, 等. 北京地区中老年人同型半胱氨酸参考区间的建立及与尿酸相关性分析[J].临床心血管病杂志, 2022, 38(4): 314-317. FANG Yazhe, GUO Nan, NIE Qingdong, et al.Establish the reference range for homocysteine in middle-aged and elderly individuals in Beijing and analyze the association between homocysteine and uric acid[J]. Journal of Clinical Cardiology, 2022, 38(4):314-317.
[5] 中华人民共和国卫生部. WS/T 402-2012：临床实验室检验项目参考区间的制定[S]. 北京：中国标准出版社, 2012. Ministry of Health of the People’s Republic of China. WS/T 402-2012：Define and determine the reference intervals in clinical laboratory [S]. Beijing：China Standards Press, 2012.
[6] 孙洪岩, 罗小玲, 孟婷, 等. 同型半胱氨酸和维生素B12 及叶酸在糖尿病视网膜病变中的含量变化及临床意义[J]. 国际眼科杂志, 2023, 23(2): 256-260. SUN Hongyan, LUO Xiaoling, MENG Ting, et al. Clinical significance and changes of homocysteine,vitamin B12 and folic acid in diabetic retinopathy[J].International Eye Science, 2023, 23(2): 256-260.
[7] 左林, 赵佳, 姜小建, 等. 缺血性脑血管病患者血清同型半胱氨酸水平与颈动脉狭窄及斑块稳定性的相关性研究[J]. 现代检验医学杂志, 2017, 32(3): 11-13, 17. ZUO Lin, ZHAO Jia, JIANG Xiaojian, et al. Correlation study between serum homocysteine level and carotid artery stenosis plaque stability in patients with ischemic cerebrovascular disease[J]. Journal of Modern Laboratory Medicine, 2017, 32(3): 11-13, 17.
[8] 刘彤, 马建军, 杨建敏, 等. 大连地区表观健康人群同型半胱氨酸参考区间的建立[J]. 检验医学与临床,2018, 15(5): 672-674. LIU Tong, MA Jianjun, YANG Jianmin, et al. Establishment of homocysteine reference intervals in apparently healthy people in Dalian[J]. Laboratory Medicine and Clinic, 2018, 15(5): 672-674.
[9] 陈柯, 范雪松, 莘琳琳, 等. 北京地区健康成人血清同型半胱氨酸水平分布情况及参考区间的建立[J].北京医学, 2022, 44(9): 809-815. CHEN Ke, FAN Xuesong, SHEN Linlin, et al. Distribution of serum homocysteine levels and establishment of reference interval in healthy adults in Beijing[J]. Beijing Medical Journal, 2022, 44(9): 809-815.
[10] 高佳, 李佳, 严翠娥, 等. 健康成人血清同型半胱氨酸的参考区间及其与性别、年龄的关系[J]. 中国临床医生杂志, 2018, 46(10): 1178-1180. GAO Jia, LI Jia, YAN Cuie, et al. Reference interval of serum homocysteine in healthy adults and its relationship with sex and age[J]. Chinese Journal for Clinicians, 2018, 46(10): 1178-1180.
[11] 邹玉, 魏伟, 姜天华, 等. 德阳地区人群血浆同型半胱氨酸水平分析及参考区间建立[J]. 检验医学与临床, 2019, 16(11): 1521-1524. ZOU Yu, WEI Wei, JIANG Tianhua, et al. Analysis of plasma homocysteine level among Deyang area population and reference interval establishment[J].Laboratory Medicine and Clinic, 2019, 16(11): 1521-1524.
[12] 王美英, 韩艳秋. 呼和浩特地区表观健康成年人群血清同型半胱氨酸水平分析和参考区间建立[J]. 现代检验医学杂志, 2022, 37(6): ：144-148. WANG Meiying, HAN Yanqiu. Serum homocysteine level analysis and reference interval establishment of epigenetically healthy adult population in Hohhot, Inner Mongolia[J]. Journal of Modern Laboratory Medicine,2022, 37(6): 144-148.
[13] 旦曲, 米玛顿珠, 普芝, 等. 拉萨地区表观健康人群血清同型半胱氨酸水平分析和参考区间初步调查[J]. 中华检验医学杂志, 2020, 43(10): 1002-1007. DAN Qu, MIMA Dunzhu, PU Zhi, et al. Preliminary investigation of serum homocysteine level and its reference interval in apparent healthy population in Lhasa area [J]. Chinese Journal of Laboratory Medicine, 2020, 43(10): 1002-1007.
[14] 张学平, 杜刚, 许海峰, 等. 克拉玛依地区健康人群血清同型半胱氨酸参考范围的建立[J]. 国际检验医学杂志, 2015, 36(19): 2885-2887. ZHANG Xueping, DU Gang, XU Haifeng, et al. Establishment of a reference range for serum homocysteine in healthy populations in the Karamay region[J]. International Journal of Laboratory Medicine,2015, 36(19): 2885-2887.
[15] LYDIA A, PRIANTONO D, HARIMURTI K, et al. The relationship between folic acid and vitamin B12 serum levels with high sensitivity C-reactive protein and homocysteine in chronic hemodialysis patients: a crosssectional study[J]. Acta Medica Indonesiana, 2021,53(3): 282-290.
[16] 左林, 赵佳, 姜小建, 等. 血清同型半胱氨酸、叶酸、维生素B12 水平与老年脑白质疏松症的相关性[J].现代检验医学杂志, 2019, 34(6): 90-92, 96. ZUO Lin, ZHAO Jia, JIANG Xiaojian, et al. Correlation study between serum homocysteine,folate, vitamin B12 levels and leukoaraiosis in elderly patients[J]. Journal of Modern Laboratory Medicine,2019, 34(6): 90-92, 96.
[17] LAVRI?A ?, HRISTOV H, HRIBAR M, et al. Dietary intake and status of vitamin B12 in slovenian population[J]. Nutrients, 2022, 14(2): 334.
[18] 李宏锦, 于海洋, 李亚楠, 等. 同型半胱氨酸水平和年龄相关疾病的研究进展[J]. 中国医药科学, 2020,10(19): 38-42, 59. LI Hongjin, YU Haiyang, LI Ya’nan, et al. The progress of research on the correlation between the level of homocysteine and age-related diseases[J]. China Medicine and Pharmacy, 2020, 10(19): 38-42, 59.
[19] ZENG Yuan, LI Feifei, YUAN Shuqian, et al. Prevalence of hyperhomocysteinemia in China: an updated meta-analysis[J]. Biology, 2021, 10(10): 959.
[20] TEIXEIRA J A, STELUTI J, GORGULHO B M, et al. Prudent dietary pattern influences homocysteine level more than folate, vitamin B12, and docosahexaenoic acid: a structural equation model approach[J]. European Journal of Nutrition, 2020, 59(1): 81-91.

备注/Memo

备注/Memo:
作者简介：姜灵路（1995-），女，本科，初级检验师，研究方向：生化检验指标的检测及解读，E-mail：1570959889@qq.com。
通讯作者：苟甜甜（1987-），女，医学硕士，副主任技师，研究方向：临床生化检验，E-mail：a362721198@126.com。
更新日期/Last Update: 2023-11-15