[1]张春艳,乔山峰.未足月胎膜早破并发组织型绒毛膜羊膜炎孕妇血液SII 与Presepsin 水平及其诊断价值分析[J].现代检验医学杂志,2024,39(03):147-151.[doi:10.3969/j.issn.1671-7414.2024.03.025]
　ZHANG Chunyan,QIAO Shanfeng.Analysis of the Diagnostic Value of Blood SII and Presepsin for Histological Chorioamnionitis in Pregnant Women with Preterm Premature Rupture of Membranes[J].Journal of Modern Laboratory Medicine,2024,39(03):147-151.[doi:10.3969/j.issn.1671-7414.2024.03.025]
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未足月胎膜早破并发组织型绒毛膜羊膜炎孕妇血液SII 与Presepsin 水平及其诊断价值分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第39卷
期数:
2024年03期
页码:
147-151
栏目:
论著
出版日期:
2024-05-15

文章信息/Info

Title:
Analysis of the Diagnostic Value of Blood SII and Presepsin for Histological Chorioamnionitis in Pregnant Women with Preterm Premature Rupture of Membranes
文章编号:
1671-7414（2024）03-147-05
作者:
张春艳; 乔山峰
（宿迁市第一人民医院妇产科，江苏宿迁 223800）
Author(s):
ZHANG Chunyan;  QIAO Shanfeng
（Department of Obstetrics and Gynecology, Suqian First Hospital, Jiangsu Suqian 223800, China）
关键词:
未足月胎膜早破; 组织型绒毛膜羊膜炎; 系统性免疫炎症指数; 可溶性白细胞分化抗原14 亚型
分类号:
R714.433；R714.62
DOI:
10.3969/j.issn.1671-7414.2024.03.025
文献标志码:
A
摘要:
目的 探讨系统性免疫炎症指数（systemic immune-inflammatory index，SII）与可溶性白细胞分化抗原14 亚型（Presepsin）对未足月胎膜早破（premature rupture of membranes，PROM）孕妇并发组织型绒毛膜羊膜炎（histologicalchorioamnionitis，HCA）的诊断价值。方法 选取2021 年6 月~2023 年6 月宿迁市第一人民医院收治的未足月PROM孕妇146 例，根据是否并发HCA 将患者分为非HCA 组（n=44）和HCA 组（n=102），另根据HCA 的组织学分期将未足月PROM 并发HCA 患者分为Ⅰ期组（n=39），Ⅱ期组（n=33），Ⅲ期组（n=30）。检测所有研究对象的SII，Presepsin，C 反应蛋白（C-reactive protein，CRP）、降钙素原（procalcitonin，PCT）水平，采用Pearson 相关系数分析指标间的相关性，受试者工作特征（receiver operating characteristic，ROC）曲线分析SII，Presepsin 等指标对未足月PROM 孕妇并发HCA 的诊断价值。结果 与非HCA 组比较，HCA 组的SII（638.96±168.12 vs 421.65±153.84），血清Presepsin（608.62±116.97 ng/L vs 453.84±102.15 ng/L），CRP（7.01±3.02 mg/L vs 4.35±1.86 mg/L），PCT（0.13±0.05μg/L vs 0.08±0.03 μg/L）升高，差异具有统计学意义（t=7.347，7.611，5.410，6.165，均P<0.05）。Ⅰ期组、Ⅱ期组、Ⅲ期组的SII 以及血清Presepsin，CRP，PCT 水平依次升高，差异具有统计学意义（F=25.794，54.230，9.459，16.774，均P<0.05）。经Pearson 分析显示，HCA 组孕妇SII 与Presepsin，CRP，PCT 呈正相关（r=0.485，0.312，0.353，均P<0.05），Presepsin 与CRP，PCT 呈正相关（r=0.472，0.421，P<0.05）。经ROC 曲线分析显示，SII，Presepsin 诊断未足月PROM 孕妇并发HCA 的曲线下面积（95% 置信区间）分别为0.859（95%CI：0.794~0.923），0.877（95%CI：0.820~0.934），明显大于CRP（0.773，95%CI：0.699~0.847）和PCT（0.774，95%CI：0.698~0.849）。结论 未足月PROM 并发HCA 孕妇的SII，Presepsin 水平升高，且两指标的水平与HCA 的组织学分期密切相关，SII，Presepsin 对未足月PROM 孕妇并发HCA 有较高的诊断价值。
Abstract:
Objective To investigate the diagnostic value of systemic immune-inflammatory index (SII) and soluble leukocyte differentiation antigen 14 subtype (Presepsin) in women with preterm premature rupture of membranes (PROM) complicated with histological chorioamnionitis (HCA). Methods A total of 146 pregnant women with preterm PROM admitted to Suqian First Hospital from June 2021 to June 2023 were selected. They were divided into non HCA group (n=44) and HCA group (n=102) based on the presence or absence of HCA. Based on the histological staging of HCA, the preterm PROM complicated with HCA group was divided into stage I group (n=39), stage II group (n=33) and stage III group (n=30). The SII, Presepsin, C-reactive protein (CRP) and procalcitonin (PCT) levels of all subjects were detected. Pearson correlation coefficient was used to analyze the correlation between these indicators. The receiver operating characteristic (ROC) curve was used to analyze the diagnostic value of SII, Presepsin and other indicators for HCA in pregnant women with preterm PROM. Results Compared with the non HCA group, the SII (638.96±168.12 vs 421.65±153.84), serum Presepsin (608.62±116.97 ng/L vs 453.84±102.15 ng/L), CRP (7.01±3.02 mg/L vs 4.35±1.86 mg/L) and PCT (0.13±0.05 μg/L vs 0.08±0.03 μg/L) of the HCA group were increased, and the differences were statistically significant (t=7.347, 7.611, 5.410, 6.165, all P<0.05). The levels of SII and serum Presepsin, CRP and PCT in stage Ⅰ , Ⅱ and Ⅲ groups were increased successively, and the differences were significant (F=25.794, 54.230, 9.459, 16.774, all P<0.05). Pearson analysis showed that SII in the HCA group was positively correlated with Presepsin, CRP and PCT (r=0.485, 0.312, 0.353, all P<0.05), and Presepsin in the HCA group was positively correlated with CRP and PCT (r=0.472, 0.421, P<0.05). ROC(95%CI) analysis showed that the areas under the curve of SII and Presepsin diagnosis of pregnant women with HCA was 0.859 (95%CI: 0.794~0.923) and 0.877 (95%CI: 0.820~0.934), respectively, which was significantly larger than those of CRP (0.773, 95%CI: 0.699~0.847), and PCT (0.774, 95%CI: 0.698- 0.849). Conclusion The levels of SII and Presepsin in pregnant women with preterm PROM complicated with HCA were higher, and the levels of these two indicators were closely related to the histological staging of HCA. SII and Presepsin may have high diagnostic value for preterm PROM pregnant women complicated with HCA.

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备注/Memo

备注/Memo:
基金项目：江苏省妇幼健康科研项目（F202049）。
作者简介：张春艳（1987-），女，本科，主治医师，研究方向：产科危急重症，E-mail：zhangchunyan330@163.com。
更新日期/Last Update: 2024-05-15