[1]刘亚东,成 欣,李先先,等.陕西省延安市成年人群血清n-HDL-C 水平参考区间的建立及影响因素分析[J].现代检验医学杂志,2024,39(04):76-82.[doi:10.3969/j.issn.1671-7414.2024.04.014]
　LIU Yadong,CHENG Xin,LI Xianxian,et al.Establishment of Reference Interval for Serum n-HDL-C Level of Adult Population in Yan’an City of Shaanxi Province and Analysis of Influencing Factors[J].Journal of Modern Laboratory Medicine,2024,39(04):76-82.[doi:10.3969/j.issn.1671-7414.2024.04.014]
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陕西省延安市成年人群血清n-HDL-C 水平参考区间的建立及影响因素分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第39卷
期数:
2024年04期
页码:
76-82
栏目:
论著
出版日期:
2024-07-15

文章信息/Info

Title:
Establishment of Reference Interval for Serum n-HDL-C Level of Adult Population in Yan’an City of Shaanxi Province and Analysis of Influencing Factors
文章编号:
1671-7414（2024）04-076-07
作者:
刘亚东1; 成 欣2; 李先先2; 雷 烨2; 唐姣姣2; 杨延星1
（1. 延安大学附属医院，陕西延安 716099；2. 延安大学医学院，陕西延安 716099）
Author(s):
LIU Yadong1;  CHENG Xin2;  LI Xianxian2;  LEI Ye2;  TANG Jiaojiao2;  YANG Yanxing1
(1. Yan’an University Affiliated Hospital, Shaanxi Yan’an 716099, China；2. Medicine School of Yan’an University, Shaanxi Yan’an 716099, China)
关键词:
非高密度脂蛋白胆固醇; 成年人群; 参考区间; 延安地区
分类号:
R446.11
DOI:
10.3969/j.issn.1671-7414.2024.04.014
文献标志码:
A
摘要:
目的 建立陕西省延安市成年人血清非高密度脂蛋白- 胆固醇（non-high-density lipoprotein cholesterol，n-HDL-C）的参考区间并分析影响因素。方法 采用随机整体抽样的方法，抽取2023 年1 ～ 9 月陕西省延安市10 个乡镇16 921例成人为研究对象。调查年龄、性别、吸烟、饮酒、锻炼、高血压、糖尿病、血脂异常、慢性病、居住、饮食习惯、婚姻状况、文化程度、月收入等。测量身高、体重、腰围和血压。检测血清三酰甘油（TG）、总胆固醇（TCHO）、高密度脂蛋白- 胆固醇（HDL-C）、低密度脂蛋白- 胆固醇（LDL-C）、载脂蛋白A1（ApoA1）、载脂蛋白B（ApoB）及脂蛋白a[Lp(a)] 水平，计算n-HDL-C 水平，n-HDL-C（mmol/L）=TCHO（mmol/L）-HDL-C（mmol/L）。按照WS/T402-2012《中华人民共和国卫生行业标准》建议的百分位数法计算95% 参考区间（P2.5 ～ P97.5）。采用多因素Logistic回归分析影响血清n-HDL-C 水平的影响因素。结果 男性和女性血清n-HDL-C 水平均呈非正态分布（S=2.119，2.091，均P<0.001）。男性＞ 60 岁血清n-HDL-C 水平[2.98（2.50，3.37）mmol/L] 与18 ～ 30 岁[2.84（2.49，3.26）mmol/L]，31 ～ 40 岁[2.98（2.62，3.42）mmol/L]，41 ～ 50 岁[3.10（2.62，3.47）mmol/L] 和51 ～ 60 岁[3.05（2.64，3.46）mmol/L] 比较，差异具有统计学意义（H=3.618 ～ 5.680，均P ＜ 0.05）；女性51 ～ 60 岁血清n-HDL-C 水平[3.08（2.71，3.44）mmol/L] 与18 ～ 30 岁[2.64（2.29，3.07）mmol/L]，31 ～ 40 岁[2.67（2.31，3.08）mmol/L]，41 ～ 50 岁[2.94（2.58，3.29）mmol/L] 比较（H=8.161 ～ 13.445，均P<0.001），＞ 60 岁血清n-HDL-C 水平[2.98（2.57，3.34）mmol/L] 与18 ～ 30岁、31 ～ 40 岁、41~50 岁比较，差异具有统计学意义（H=7.985~14.018，均P<0.001）。将无统计学意义的年龄组合并，得到成年人群血清n-HDL-C 水平参考区间：男性18 ～ 60 岁（1.97 ～ 3.97mmol/L），＞ 60 岁（1.86 ～ 3.91mmol/L）；女性18 ～ 50 岁（1.82 ～ 3.74mmol/L），＞ 50 岁（1.94 ～ 3.88mmol/L）。将纳入的16 921 例成人分为n-HDL-C 水平正常组和异常组，两组血清TG（1.02±0.31 mmol/L vs 1.24±0.37mmol/L），TCHO（3.97±1.02 mmol/L vs 4.66±1.25mmol/L），LDL-C（2.37±0.58mmol/L vs 2.59±0.67 mmol/L）水平及年龄（43.55±11.52 岁 vs 46.27±8.13 岁）比较，差异具有统计学意义（t=2.041 ～ 3.151，均P ＜ 0.05），血清n-HDL-C 水平异常率42.50%。经多因素Logistic 回归分析，男性、锻炼缺乏、超重和肥胖、血脂异常、城市居民、高中及以上学历是该地区成年人血清n-HDL-C 水平的影响因素（均P ＜ 0.05）。结论 初步建立了该地区成年人血清n-HDL-C 水平参考区间，男性、锻炼缺乏、超重和肥胖、血脂异常、城市居民、高中及以上学历是该地区成年人血清n-HDL-C 水平异常的影响因素。
Abstract:
Objective To establish the reference interval of serum non-high-density lipoprotein cholesterol (n-HDL-C) in adults in Yan’an city of Shaanxi Province and analyze the influencing factors. Methods A total of 16 921 adults from 10 towns in Yan’an City of Shaanxi Province from January to September 2023 were selected by random sampling. Age, sex, smoking,drinking, exercise, hypertension, diabetes, dyslipidemia, chronic disease, residence, eating habits, marital status, education and monthly income were investigated. Height, weight, waist circumference and blood pressure were measured. Serum triglyceride (TG), total cholesterol (TCHO), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), Apolipoprotein A1 (ApoA1), Apolipoprotein B (ApoB) and lipoprotein a [Lp(a)] levels were detected, and n-HDL-C levels were calculated: n-HDL-C (mmol/L) = TCHO (mmol/L)-HDL-C (mmol/L). The 95% reference interval (P2.5 ～ P97.5) was calculated according to the percentile method recommended in WS/T402-2012 Health Industry Standard of the People’s Republic of China. Multivariate logistic regression was used to analyze the influencing factors of serum n-HDL-C level. Results The serum n-HDL-C levels in both males and females were not normally distributed (S=2.119, 2.091, all P<0.001). There were significant differences in serum levels of n-HDL-C among males aged ＞ 60 years old [2.98 (2.50, 3.37) mmol/L], 18 ～ 30 years old [2.84 (2.49, 3.26) mmol/L], 31 ～ 40 years old [2.98 (2.62, 3.42) mmol/L], 41 ～ 50 years old [3.10 (2.62, 3.47) mmol/L] and 51 ～ 60 years old [3.05 (2.64, 3.46) mmol/L] contrast, and the differences were significant (H=3.618 ～ 5.680, all P ＜ 0.05). There were significant differences in serum levels of n-HDL-C among women aged 51 ～ 60 years [3.08 (2.71, 3.44) mmol/L], 18 ～ 30 years [2.64 (2.29, 3.07) mmol/L], 31 ～ 40 years [2.67 (2.31, 3.08) mmol/L] and 41 ～ 50 years old [2.94 (2.58, 3.29) mmol/L] contrast (H= 8.161~13.445, all P<0.001). There were significant differences in serum n-HDL-C levels among patients aged ＞ 60 years old [2.98 (2.57, 3.34) mmol/L], 18 ～ 30 years old, 31 ～ 40 years old and 41 ～ 50 years old contrast, and the differences were significant (H=7.985 ～ 14.018, all P<0.001). The reference interval of serum n-HDL-C level in adult population was obtained by combining the age groups with no statistical significance: males aged 18 ～ 60 years old (1.97 ～ 3.97mmol/L), ＞ 60 years old (1.86 ～ 3.91mmol/L); females aged 18 ～ 50 years (1.82 ～ 3.74 mmol/L), ＞ 50 years old (1.94 ～ 3.88 mmol/L). A total of 16 921 adults were divided into normal n-HDL-C group and abnormal group, and the differences of serum TG （1.02±0.31 mmol/L vs 1.24±0.37mmol/L）, TCHO（3.97±1.02 mmol/L vs 4.66±1.25 mmol/L）, LDL-C （2.37±0.58mmol/ L vs 2.59±0.67 mmol/L）levels and age（43.55±11.52 years vs 46.27±8.13 years） between the two groups were significant (t=2.041 ～ 3.151, all P ＜ 0.05), in which the abnormal rate of serum n-HDL-C level was 42.50%. Multivariate Logistic regression analysis showed that males, lack of exercise, overweight or obesity, dyslipidemia, urban residents, and high school education or above were the influential factors for serum n-HDL-C levels in adults in this region (all P ＜ 0.05). Conclusion The reference interval of serum n-HDL-C level in adults in this area was preliminarily established. Males, lack of exercise, overweight or obesity, dyslipidemia, urban residents, and high school education or above were the influential factors of abnormal serum n-HDL-C levels in adults in this area.

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相似文献/References:

[1]程俊杰,李 静,梁西强,等.非高密度脂蛋白胆固醇 与冠心病患者心功能分级的相关性研究[J].现代检验医学杂志,2016,31(03):43.[doi:10.3969/j.issn.1671-7414.2016.03.012]
　CHENG Jun-jie,LI Jing,LIANG Xi-qiang,et al.Correlation between Non High Density Lipoprotein Cholesterol and Cardiac Function in Patients with Coronary Heart Disease[J].Journal of Modern Laboratory Medicine,2016,31(04):43.[doi:10.3969/j.issn.1671-7414.2016.03.012]

备注/Memo

备注/Memo:
基金项目： 陕西省大学生创新创业训练计划项目（项目编号：S202210719122）; 延安大学大学生创新创业训练计划项目（项目编号：D2021232）；延安市科技计划项目（项目编号：2022SLSFG G-057）。
作者简介：刘亚东（1988-），男，本科，副主任检验技师，研究方向：心血管疾病检验诊断。
通讯作者：杨延星，E-mail：18091102099@163.com。
更新日期/Last Update: 2024-07-15