[1]郭晓莉a,惠 晶b,惠 慧.多囊卵巢综合征患者血清前蛋白转化酶枯草溶菌素9表达水平与糖脂代谢及胰岛素抵抗的相关性研究[J].现代检验医学杂志,2025,40(02):156-159.[doi:10.3969/j.issn.1671-7414.2025.02.029]
　GUO Xiaolia,HUI Jingb,HUI Hui.Study on the Correlation between Serum Proprotein Convertase Subtilisin/ Kexin Type 9 and Glucose and Lipid Metabolism and Insulin Resistance in Patients with Polycystic Ovary Syndrome[J].Journal of Modern Laboratory Medicine,2025,40(02):156-159.[doi:10.3969/j.issn.1671-7414.2025.02.029]
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多囊卵巢综合征患者血清前蛋白转化酶枯草溶菌素9表达水平与糖脂代谢及胰岛素抵抗的相关性研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第40卷
期数:
2025年02期
页码:
156-159
栏目:
论著
出版日期:
2025-03-15

文章信息/Info

Title:
Study on the Correlation between Serum Proprotein Convertase Subtilisin/ Kexin Type 9 and Glucose and Lipid Metabolism and Insulin Resistance in Patients with Polycystic Ovary Syndrome
文章编号:
1671-7414（2025）02-156-04
作者:
郭晓莉1a; 惠 晶1b; 惠 慧2
（1. 延安市人民医院a. 妇产科一病区；b. 妇产科二病区，陕西延安 716000；2. 延安市中医医院妇科，陕西延安 716000）
Author(s):
GUO Xiaoli1a; HUI Jing1b; HUI Hui2
(1a. Department of Obstetrics and Gynecology；1b. the Second Ward of Obstetrics and Gynecology, Yan’an People’s Hospital，Shaanxi Yan’an 716000，China；2. Department of Gynecology，Yan’an Hospital of Traditional Chinese Medicine，Shaanxi Yan’an 716000，China)
关键词:
多囊卵巢综合征; 前蛋白转化酶枯草溶菌素9; 胰岛素抵抗; 糖脂代谢
分类号:
R711.75；R446.11
DOI:
10.3969/j.issn.1671-7414.2025.02.029
文献标志码:
A
摘要:
目的 探讨血清前蛋白转化酶枯草溶菌素9（PCSK9）与多囊卵巢综合征（PCOS）患者糖脂代谢和胰岛素抵抗（IR）的关系。方法 选取2019 年6 月～ 2021 年8 月延安市人民医院收治的初诊PCOS 患者154 例作为PCOS 组，采用稳态模型计算患者的胰岛素抵抗指数（HOMA-IR），将HOMA-IR<2.69 者纳入到非IR 组（n=62），HOMA-IR ≥ 2.69 者纳入到IR 组（n=92）。另选取同期延安市人民医院体检结果为正常的健康志愿者50 例作为对照组。采用酶联免疫试剂盒检测血清PCSK9 的水平。比较所有研究对象的性激素指标以及糖脂代谢指标差异。Pearson 相关分析PCOS 患者血清PCSK9 与糖脂代谢指标及性激素指标的关系；多因素Logistics 回归分析PCOS 患者并发IR 的影响因素。结果 PCOS 组血清PCSK9（292.57±42.31ng/ml）高于对照组（226.94±20.18ng/ml），差异具有统计学意义（t=10.379，P<0.001）。IR 组患者血清PCSK9（324.51±50.33 ng/m l）高于非IR 组（245.18±40.16 ng/ml），差异具有统计学意义（t=10.379，P<0.001）。Pearson 分析显示，PCOS 患者血清PCSK9 与LH，空腹血糖、空腹胰岛素、HOMA-IR，LDL-C，TC 和TG 均呈正相关（r=0.302 ～ 0.684，均P<0.05）。经多因素Logsitic 回归分析显示，空腹血糖、空腹胰岛素和血清PCSK9 均是PCOS 患者并发IR 的影响因素（Wald χ2=8.501，8.024，7.886，均P ＜ 0.05）。结论 PCSK9 在PCOS 患者血清中呈异常高表达，且其表达水平与患者的糖脂代谢以及IR 情况密切相关。
Abstract:
Objective To investigate the relationship between serum proprotein convertase subtilisin/kexin type 9 (PCSK9) and glucose and lipid metabolism and insulin resistance (IR) in patients with polycystic ovary syndrome (PCOS). Methods 154 newly diagnosed PCOS patients admitted to Yan’an People’s Hospital from June 2019 to August 2021 were selected as the PCOS group.The homeostasis model assessment of insulin resistance index (HOMA-IR) of patients, those with HOMA-IR<2.69 were included in the non IR group (n=62), and those with HOMA-IR ≥ 2.69 were included in the IR group (n=92). Another 50 healthy volunteers with normal physical examination results were selected as the control group. The level of serum PCSK9 was detected by ELISA kit. The sex hormone indexes and glucose lipid metabolism indexes of all subjects were compared. The relationship between serum PCSK9, glucose and lipid metabolism indexes, and sex hormone indexes in PCOS patients were analyzed by Pearson correlation. The factors influencing IR in PCOS patients were analyzed using binary logistics regression. Results Serum PCSK9 in PCOS group(292.57±42.31 ng/ml）was higher than that in control group（226.94±20.18 ng/ml）, the difference was statistically significant（t=10.379, P<0.001). Serum PCSK9 in IR group(324.51±50.33 ng/ml）was higher than that in non- IR group（245.18±40.16 ng/ml)，the difference was statistically significant（t=10.379, P<0.001). Pearson analysis showed that serum PCSK9 of PCOS patients was positively correlated with LH, fasting blood glucose, fasting insulin, HOMA-IR, LDL-C, total cholesterol, and triglyceride (r=0.302 ～ 0.684，all P<0.05). Multivariate Logsitic regression analysis showed that fasting blood glucose，fasting insulin and serum PCSK9 were the influencing factors of IR in PCOS patients（Wald χ2=8.501， 8.024，7.886，all P ＜ 0.05）. Conclusion PCSK9 is abnormally high expressed in serum of PCOS patients, and its expression level is closely related to the glucose and lipid metabolism and IR status of patients.

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备注/Memo

备注/Memo:
基金项目：陕西省自然科学基础研究计划（2018JQ2043）。
作者简介： 郭晓莉（1987-），女，本科，主治医师，研究方向：多囊卵巢综合征、子宫内膜异位症、妊娠期糖尿病，E-mail：guoxiaoli1698@163.com。
通讯作者：惠慧（1990-），女，本科，主治医师，研究方向：妇产科常见病的诊疗，E-mail：664381360@qq.com。
更新日期/Last Update: 2025-03-15