[1]徐 超1,祝兴元2,黄彩芝2,等.中国部分省市临床过敏患者血清链格孢霉和烟曲霉特异性IgE抗体检测的多中心调查研究[J].现代检验医学杂志,2025,40(03):13-17.[doi:10.3969/j.issn.1671-7414.2025.03.003]
　XU Chao1,ZHU Xingyuan2,HUANG Caizhi2,et al.Multi-center Study on Specific IgE Antibodies to Alternaria Alternata and Aspergillus Fumigatus in Sera of Clinical Allergy Patients in Selected Provinces in China[J].Journal of Modern Laboratory Medicine,2025,40(03):13-17.[doi:10.3969/j.issn.1671-7414.2025.03.003]
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中国部分省市临床过敏患者血清链格孢霉和烟曲霉特异性IgE抗体检测的多中心调查研究()

《现代检验医学杂志》[ISSN:/CN:]

卷:
第40卷
期数:
2025年03期
页码:
13-17
栏目:
论著
出版日期:
2025-05-15

文章信息/Info

Title:
Multi-center Study on Specific IgE Antibodies to Alternaria Alternata and Aspergillus Fumigatus in Sera of Clinical Allergy Patients in Selected Provinces in China
文章编号:
1671-7414（2025）03-013-05
作者:
徐 超1，祝兴元2，黄彩芝2，朱 鸿3，王 树4，袁红霞5，赵鹏飞6，闫 吉7，马建华8，邝春雷9，谢艳丽10，吴荣才11，张 瑜12，梁 盛13,汪群英14，段颖莎15，郑轶武16
[1. 大连妇女儿童医疗中心（集团）呼吸实验室，辽宁大连 116000；2. 湖南省儿童医院检验科，长沙 410000；3.大连医科大学附属第一医院检验科，辽宁大连116000；4. 蚌埠市第三人民医院检验科，安徽蚌埠 233000；5. 郴州市第一人民医院检验科，湖南郴州 423000；6.丹东市第一医院检验科，辽宁丹东 118000；7. 沈阳市第四人民医院检验科，沈阳 110000；8. 辽宁省健康产业集团铁煤总医院检验科，沈阳 110000；9. 项城敏好佳医院，河南周口 466000；10. 武汉科技大学附属天佑医院变态反应科，武汉 430000；11. 广西壮族自治区人民医院检验科，南宁 530000；12. 重庆高新区第一人民医院检验科，重庆 401300；13. 广西横州市人民医院检验科，南宁 530000；14. 郑州大学第一附属医院消化科，郑州 450000；...
Author(s):
XU Chao1，ZHU Xingyuan2，HUANG Caizhi2，ZHU Hong3，WANG Shu4，YUAN Hongxia5，ZHAO Pengfei6， YAN Ji7，MA Jianhua8，KUANG Chunlei9，XIE Yanli10，WU Rongcai11，ZHANG Yu12，LIANG Sheng13， WANG Qunying14，DUAN Yingsha15，ZHENG Yiwu16
（1. Respiratory Laboratory，Dalian Women and Children’s Hospital （Medical Group）, Liaoning Dalian 116000，China；2. Department of Clinical Laboratory，Hunan Children’s Hospital，Changsha 410000，China；3. Department of Clinical Laboratory，the First Affiliated Hospital of Dalian Medical University，Liaoning Dalian 116000，China；4. Department of Clinical Laboratory，the Third People’s Hospital of Bengbu，Anhui Bengbu 233000，China；5. Department of Clinical Laboratory，Chenzhou First People’s Hospital，Hunan Chenzhou 423000，China；6. Department of Clinical Laboratory，Dandong First Hospital, Liaoning Dandong 118000，China；7. Department of Clinical Laboratory, the Fourth People’s Hospital of Shenyang，Shenyang 110000，China；8. Department of Clinical Laboratory，Liaoning Health Industry Group Tiemei Hospital，Shenyang 110000，China；9. Xiangcheng Minhaojia Hospital，Henan Zhoukou 466000，China；...
关键词:
链格孢霉; 烟曲霉; 免疫球蛋白E
分类号:
R593.1；R446.62
DOI:
10.3969/j.issn.1671-7414.2025.03.003
文献标志码:
A
摘要:
目的考察中国部分省市临床过敏患者血清链格孢霉和烟曲霉特异性IgE抗体阳性情况。方法选取11个省、17个城市的20家医院检验科过敏原特异性IgE抗体检测数据，分析链格孢霉和烟曲霉特异性IgE抗体水平及其在不同省区及不同季节的变化情况。结果研究分别纳入链格孢霉和烟曲霉特异性IgE数据27471例和32843例。链格孢霉IgE抗体全国平均阳性率为10.40%，江苏最高（22.68%），广西最低（2.06%）。烟曲霉IgE抗体平均阳性率为4.24%，湖北省最高（7.25%），湖南省最低（1.23%）；不同省区链格孢霉和烟曲霉IgE水平的差异具有统计学意义（H=9955，16993，均P<0.0001）。链格孢霉特异性IgE水平达到3级及以上的患者为5.84%，而烟曲霉3级及以上仅为0.57%。以辽宁、湖南、安徽三省数据考察特异性IgE抗体的季节性变化，链格孢霉和烟曲霉IgE抗体均具有显著的季节性变化（H链格孢霉=347.6，338.0，401.3，H烟曲霉=196.6，133.7，231.7，均P<0.0001）。结论链格孢霉和烟曲霉致敏具有明显的地域特性，且随季节变化，链格孢霉IgE水平较高，应引起足够的临床重视。
Abstract:
Objective To investigate the prevalence of specific IgE antibodies against Alternaria alternata and Aspergillus fumigatus in serum samples from clinical allergy patients across selected provinces in China. Methods Data on specific IgE antibodies for Alternaria A. and Aspergillus F. were collected from 20 hospital laboratories in 17 cities spanning 11 provinces. The study analyzed the levels of specific IgE and their variations across different provinces and seasons. Results A total of 27 471 cases of Alternaria A. and 32 843 cases of Aspergillus F. specific IgE data were included. The national average positive rate of Alternaria A. IgE was 10.40%, with the highest rate of 22.68% in Jiangsu and the lowest rate of 2.06% in Guangxi. For Aspergillus F . specific IgE, the average positive rate was 4.24%, with Hubei province having the highest rate (7.25%) and Hunan province the lowest (1.23%). The difference in IgE levels for both Alternaria A. and Aspergillus F. among provinces were statistically significant (H=9 955, 16 993, all P<0.0001). Among patients, 5.85% had Alternaria A. specific IgE levels at grade 3 or above, while only 0.57% had Aspergillus F. specific IgE levels at this level. When examining seasonal variations using data from Liaoning, Hunan and Anhui provinces, significant seasonal changes were observed for both Alternaria A. and Aspergillus F. IgE antibodies ( HAlternaria A=347.6, 338.0, 401.3, HAspergillus F=196.6, 133.7, 231.7, all P<0.0001). Conclusion The sensitization to Alternaria A. and Aspergillus F. exhibits distinct geographical characteristics and vary significantly with seasons. Given the relatively high IgE levels associated with Alternaria A., it should be given adequate clinical attention.

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备注/Memo

备注/Memo:
作者简介： 徐超（1987-），女，硕士，副主任中医师，研究方向：小儿呼吸系统疾病及变态反应性疾病，E-mail:783678099@qq.com。
通讯作者： 黄彩芝（1976-），女，硕士，主任技师，研究方向：儿童感染性疾病与变态反应性疾病的实验室诊断，E-mail:hncshcz@163.com。郑轶武(1973-)，男，博士，副主任药师，研究方向：过敏原、过敏性疾病的诊断、脱敏治疗等，E-mail:zhengyiwu@hob-biotech.com，同为通讯作者。
更新日期/Last Update: 2025-05-15