[1]杨海燕,翁洁瑶,钱怡琳,等.急性ST段抬高型心肌梗死患者血清IRGM，Syndecan-1水平表达对PCI术后预后的影响[J].现代检验医学杂志,2025,40(03):123-128.[doi:10.3969/j.issn.1671-7414.2025.03.023]
　YANG Haiyan,WENG Jieyao,QIAN Yilin,et al.Effect of Serum IRGM, Syndecan-1 Level Expression on Prognosis after PCI in Patients with Acute ST-segment Elevation Myocardial Infarction[J].Journal of Modern Laboratory Medicine,2025,40(03):123-128.[doi:10.3969/j.issn.1671-7414.2025.03.023]
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急性ST段抬高型心肌梗死患者血清IRGM，Syndecan-1水平表达对PCI术后预后的影响()

《现代检验医学杂志》[ISSN:/CN:]

卷:
第40卷
期数:
2025年03期
页码:
123-128
栏目:
论著
出版日期:
2025-05-15

文章信息/Info

Title:
Effect of Serum IRGM, Syndecan-1 Level Expression on Prognosis after PCI in Patients with Acute ST-segment Elevation Myocardial Infarction
文章编号:
1671-7414（2025）03-123-06
作者:
杨海燕，翁洁瑶，钱怡琳，王瑾枫，张 凯
（上海交通大学医学院苏州九龙医院检验科，江苏苏州 215000）
Author(s):
YANG Haiyan，WENG Jieyao，QIAN Yilin，WANG Jinfeng，ZHANG Kai
(Department of Clinical Laboratory， Suzhou Jiulong Hospital of Shanghai Jiaotong University School of Medicine，Jiangsu Suzhou 215000，China)
关键词:
急性ST段抬高型心肌梗死; 免疫相关鸟苷三磷酸酶M蛋白; 多配体蛋白聚糖-1; 经皮冠状动脉介入治疗
分类号:
R542.22；R392.11
DOI:
10.3969/j.issn.1671-7414.2025.03.023
文献标志码:
A
摘要:
目的探讨急性ST段抬高型心肌梗死（ASTEMI）患者血清免疫相关鸟苷三磷酸酶M蛋白（IRGM）和多配体蛋白聚糖-1（Syndecan-1）水平表达对经皮冠状动脉介入治疗（PCI）术后预后的影响。方法选取2021年1月～2023年1月上海交通大学医学院苏州九龙医院收治的ASTEMI患者135例（ASTEMI组），PCI治疗三个月后分为不良预后组（n=37）和良好预后组（n=98）；另选取同期65例体检健康者（对照组）。采用酶联免疫吸附法（ELISA）检测血清IRGM，Syndecan-1水平，Logistic回归分析ASTEMI患者PCI术后不良预后的影响因素，并绘制受试者工作特征（ROC）曲线评价血清IRGM，Syndecan-1水平对ASTEMI患者PCI术后不良预后的预测价值。结果与对照组比较，ASTEMI组血清IRGM（6.17±2.50ng/mlvs2.59±0.94ng/ml），Syndecan-1（420.97±123.65ng/mlvs278.89±43.06ng/ml）水平更高，差异具有统计学意义（t＝14.628，11.932，均P＜0.01）。随访三个月，135例ASTEMI患者PCI术后不良预后发生率为27.41%（37/135）；不良预后组患者年龄、KILLIP分级≥Ⅱ级占比、Gensini评分、白细胞计数、LDL-C，IRGM，Syndecan-1水平高于良好预后组，LVEF分数低于良好预后组，差异具有统计学意义（χ2/t/Z=2.119～8.042，均P＜0.05）。ASTEMI患者PCI术后KILLIP分级≥Ⅱ级、Gensini评分高、IRGM高表达、Syndecan-1高表达为不良预后的独立危险因素；LVEF分数高为独立保护因素（Waldχ2=4.225～11.413，均P＜0.05）。血清IRGM，Syndecan-1水平联合预测ASTEMI患者PCI术后不良预后的曲线下面积高于IRGM，Syndecan-1单独预测，差异具有统计学意义（Z＝3.400，2.905，均P＜0.05）。结论血清IRGM，Syndecan-1水平高是ASTEMI患者PCI术后不良预后的独立危险因素，血清IRGM，Syndecan-1水平联合对其有较高的预测价值。
Abstract:
Objective To investigate the effect of serum expression of immune-related guanosine triphosphatase M (IRGM) and Syndecan-1levels in patients with acute ST-segment elevation myocardial infarction (ASTEMI) on the prognosis after percutaneous coronary intervention (PCI). Methods 135 patients with ASTEMI admitted to Suzhou Jiulong Hospital of Shanghai Jiaotong University School of Medicine from January 2021 to January 2023 (ASTEMI group) were selected and divided into the poor prognosis group (n=37) and the good prognosis group (n=98) after PCI treatment for 3 months, and 65 physically examined and healthy people (control group) were also selected during the same period. The enzyme-linked immunosorbent assay（ELISA） was used to detect serum IRGM, Syndecan-1 levels, Logistic regression was used to analyze the influencing factors of poor prognosis after PCI in ASTEMI patients, and receiver operating characteristic(ROC) curves were plotted to evaluate the predictive value of serum IRGM, Syndecan-1 levels on poor prognosis after PCI in ASTEMI patients. Results Compared with the control group, serum IRGM (6.17±2.50 ng/ml vs 2.59±0.94 ng/ml), Syndecan-1 (420.97±123.65 ng/ml vs 278.89±43.06 ng/ml) levels were higher in the ASTEMI group, and the differences were statistically significant (t=14.628, 11.932, all P<0.001). During a three-month follow-up, the incidence of poor prognosis after PCI in 135 patients with ASTEMI was 27.41% (37/135). The age, proportion of KILLIP grade ≥ II, Gensini score, white blood cell count, LDL-C, IRGM and Syndecan-1 levels in the poor prognosis group were higher than those in the good prognosis group, and the LVEF scores was lower than those in the good prognosis group, and the differences were statistically significant (χ2/t/Z=2.119～8.042，all P<0.05). Independent risk factors for poor prognosis after PCI in patients with ASTEMI were KILLIP classification≥ II，high Gensini score，high IRGM，high Syndecan-1, and high LVEF were the independent protective factors (Wald χ2=4.225～11.413, all P<0.05). The AUC（95%CI） of serum IRGM combined with Syndecan-1 level in predicting poor prognosis in patients with ASTEMI after PCI was larger than that of IRGM, and Syndecan-1 alone predictsed poor prognosis, and the differences were statistically significant (Z=3.400, 2.905, all P<0.05). Conclusion High serum IRGM, Syndecan-1 level is an independent risk factor for poor prognosis after PCI in pa-tients with ASTEMI, and the combination of serum IRGM, Syndecan-1 level has a high predictive value for it.

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备注/Memo

备注/Memo:
基金项目：江苏省卫生健康委科研课题（BJ22017)。
作者简介：杨海燕（1988-），女，大学本科，主管检验师，研究方向：心血管疾病的临床检验，E-mail：wjy8403@163.com。
通讯作者：翁洁瑶，研究方向：心血管疾病的临床检验，E-mail：258975986@qq.com。
更新日期/Last Update: 2025-05-15