[1]庞晓燕,王晓华,冀云鹏,等.2020～2022年呼和浩特地区0～1岁儿童巨细胞病毒感染的血清学检测及危险因素分析[J].现代检验医学杂志,2025,40(05):153-157.[doi:10.3969/j.issn.1671-7414.2025.05.029]
　PANG Xiaoyan,WANG Xiaohua,JI Yunpeng,et al.Serologic Testing and Risk Factor Analysis of Human Cytomegalovirus Infection in Children Aged 0~1 Years in Hohhot Region, 2020~2022[J].Journal of Modern Laboratory Medicine,2025,40(05):153-157.[doi:10.3969/j.issn.1671-7414.2025.05.029]
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2020～2022年呼和浩特地区0～1岁儿童巨细胞病毒感染的血清学检测及危险因素分析()

《现代检验医学杂志》[ISSN:/CN:]

卷:
第40卷
期数:
2025年05期
页码:
153-157
栏目:
论著
出版日期:
2025-09-15

文章信息/Info

Title:
Serologic Testing and Risk Factor Analysis of Human Cytomegalovirus Infection in Children Aged 0~1 Years in Hohhot Region, 2020~2022
文章编号:
1671-7414（2025）05-153-05
作者:
庞晓燕，王晓华，冀云鹏，李 璐，宋月欣，周雪原
内蒙古自治区妇幼保健院遗传优生科/医学遗传学内蒙古自治区工程研究中心，呼和浩特 010020
Author(s):
PANG Xiaoyan，WANG Xiaohua，JI Yunpeng，LI Lu，SONG Yuexin，ZHOU Xueyuan
Department of Genetics Eugenics, Maternital and Child Health Hospital of Inner Mongolia/Inner Mongolia Autonomous Region Engineering Research Center of Medical Genetics，Hohhot 010020，China
关键词:
人巨细胞病毒感染; 血清学检测; 母乳喂养; 阴道分娩; 危险因素
分类号:
R373.11；R446.6
DOI:
10.3969/j.issn.1671-7414.2025.05.029
文献标志码:
A
摘要:
目的研究0～1岁儿童巨细胞病毒（CMV）血清学流行率和感染状况，探讨CMV感染的危险因素，为临床提供参考。方法回顾性分析2020年1月～2022年12月内蒙古自治区妇幼保健院儿内科门诊或住院部就诊的所有行化学发光（CL）法检测TORCH的0～1岁4938例患儿资料，了解该地区儿童人巨细胞病毒（HCMV）血清流行率，结合实验室检测结果和临床信息，分析HCMV感染的相关危险因素。结果4938例患儿总抗体阳性率94.01%(4642/4938)，总IgG抗体阳性率93.86%（4635/4938），总IgM抗体阳性率8.10%（400/4938），两者同时检出阳性率为7.96%（393/4938）。不同年龄组之间HCMV-IgG和HCMV-IgM抗体阳性率比较，差异具有统计学意义（χ2=36.350，1043.199，均P<0.05）；男童与女童HCMV-IgG和IgM抗体阳性率比较，差异无统计学意义（χ2=0.215，1.184，均P＞0.05）。经单因素分析，感染组母乳喂养率和阴道分娩率高于对照组，喂养方式和出生方式差异具有统计学意义（χ2=10.777，5.725，均P<0.05）。多因素分析发现，母乳喂养和阴道分娩是HCMV感染的独立危险因素，差异具有统计学意义（Waldχ2=6.247，10.057，均P<0.05）。结论?1岁内儿童HCMV血清学抗体阳性率高达94.01%，3～6月龄婴儿最易感染。母乳喂养和经阴道分娩是1岁内儿童HCMV感染的独立危险因素。
Abstract:
Objective To understand the serologic prevalence and infection status of Cytomegalovirus（CMV）in children aged 0～1 years, and explore the risk factors of CMV infection for clinical reference. Methods The data of 4 938 children aged 0~1 years who underwent chemiluminescence enzyme immunoassay for TORCH in Department of Inpatient and Department of Pediatrics Outpatient of Maternal and Child Health Hospital of Inner Mongolia from January 2020 to December 2022 were retrospectively analyzed to understand the seroprevalence of human CMV (HCMV) among children in the region, and analyzed the risk factors associated with HCMV infections by combining the results of laboratory tests and clinical information. Results In 4 938 children, the total antibody positivity rate was 94.01% (4 642/4 938)，the total IgG antibody positivity rate was 93.86% (4 635/4 938), the total IgM antibody positivity rate was 8.10% (400/4 938)，and the positive rate of the two simultaneous detections was 7.96% (393/4 938). The difference in HCMV-IgG and HCMV-IgM antibodies positivity rates beteen different age groups were statistically significant (χ2=36.350，1 043.199，all P<0.05), and the differences in HCMV-IgG and IgM antibodies between boys and girls were not statistically significant (χ2=0.215, 1.184，all P＞0.05). According to univariate analysis, the breast-feeding and vaginal delivery rates in the infected group were higher than those in the control group, and the differences in feeding and birth methods were statistically significant (χ2=10.777, 5.725, all P<0.05). Multifactorial analysis found that breast-feeding and transvaginal delivery were independent risk factors for HCMV infection，and the differences was statistically significant (Wald χ2=6.247, 10.057, all P<0.05). Conclusion The serologic antibody positivity rate of HCMV in children within 1 year of age is as high as 94.01%, and infants aged 3 months to 6 months are most susceptible to infection. Breastfeeding and transvaginal delivery are independent risk factors for HCMV infection in children within 1 year of age.

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备注/Memo

备注/Memo:
基金项目：内蒙古自治区妇幼保健院院内科研项目（2024FYYNC033）。
作者简介：庞晓燕（1994-），女，硕士研究生，主管检验师，从事临床分子微生物检验工作，E-mail: 1295156732@qq.com。
通讯作者：周雪原（1986-），女，硕士研究生，主管检验师，从事临床分子微生物检验工作， E-mail: 382263699@qq.com。
更新日期/Last Update: 2025-09-15