[1]赵辉.抗CCP抗体,AKA与RF联合检测在类风湿关节炎诊断中的临床意义[J].现代检验医学杂志,2015,30(05):159-161.[doi:10.3969/j.issn.1671-7414.2015.05.051]
 ZHAO Hui.Clinical Significance of Anti-CCP Antibody and Anti-AKA Antibody and Rheumatoid Factor in Rheumatoid Arthritis[J].Journal of Modern Laboratory Medicine,2015,30(05):159-161.[doi:10.3969/j.issn.1671-7414.2015.05.051]
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抗CCP抗体,AKA与RF联合检测在类风湿关节炎诊断中的临床意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第30卷
期数:
2015年05期
页码:
159-161
栏目:
检验与临床
出版日期:
2015-12-10

文章信息/Info

Title:
Clinical Significance of Anti-CCP Antibody and Anti-AKA Antibody and Rheumatoid Factor in Rheumatoid Arthritis
作者:
赵辉
延安大学附属医院,陕西延安716000
Author(s):
ZHAO Hui
the Affiliated Hospital of Yan’an University,Shaanxi Yanan 716000,China
关键词:
抗环瓜氨酸肽抗体抗角蛋白抗体类风湿因子类风湿关节炎联合检测
分类号:
R593.22;R392.11
DOI:
10.3969/j.issn.1671-7414.2015.05.051
文献标志码:
A
摘要:
目的评价抗CCP抗体,AKA与RF联合检测在类风湿关节炎(RA)诊断中的临床意义。方法对80例RA患者、103例非RA患者和30例健康对照者血清标本分别采用ELISA法、间接免疫荧光法、散射比浊法检测抗CCP抗体,AKA和RF。结果①抗CCP抗体,AKA和RF在非RA组中的阳性检出率分别为2.9%,1.9%和22.3%,RA组阳性检出率分别为71.3%,46.3%和80%,两组间比较差异均具有统计学意义(χ2=33.4,17.7,24.1,P<0.05);②单独检测时,抗CCP抗体,AKA和RF敏感度分别为71.3%,46.3%和80%,特异度分别为96.2%,98.5%和80.5%。联合检测时,抗CCP+RF对RA的敏感度最高(48.8%),两两联合或三者联合检测的特异度显著提高(98.5%~100%)。结论抗CCP抗体,AKA和RF联合检测可以提高RA早期诊断的准确率,降低误诊率及漏诊率。
Abstract:
ObjectiveTo evaluate the clinical significance of the combined detection of anti-cyclic citrullinated peptide (Anti-CCP) antibody ,anti-keration antibody (AKA) and rheumatoid factor (RF) for the diagnosis of rheumatoid arthritis (RA) in primary hospital.MethodsAnti-CCP antibody was detected by using ELISA and AKA was detected by the indirect immunofluorescence method and RF was detected by scattering turbidimetry in 80 patients with RA,103 patients with non-RA rheumatic disease with joint discomfort and 30 healthy subjects as control.Results①The positive rate of anti-CCP,anti-MCV and RF was 71.3%,46.3% and 80% respectively in patients with RA,and 2.9%,1.9%,22.3% respectively in patients with non-RA,that was significantly higher than those patients with non-RA (χ2=33.4,17.7,24.1,P<0.05).②The sensitivity and specificity of anti-CCP antibody was 71.3% and 96.2%,that of AKA was 46.3%,98.5%,that of RF was 80%,80.5% respectively.The combined detection of anti-CCP antibody and RF had the highest sensitivity (48.8%).The combined detection of two or three antibodies had significantly higher specificity (98.5%~100%).ConclusionThe combined detection of anti-CCP antibody,AKA and RF can significantly improve the diagnostic efficiency and reduce the misdiagnosis rate and the omission diagnose rate.

参考文献/References:

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备注/Memo

备注/Memo:
作者简介:赵辉(1980-),男,硕士,主治医师,长期从事类风湿关节炎、强直性柱脊炎、系统性红斑狼疮等风湿病临床工作,Tel:15191116390,E-mail:zzhhss@163.com。
更新日期/Last Update: 1900-01-01