[1]党珊a,周健a,杨帆b,等.胰腺癌组织中缺氧诱导因子-2α的表达及临床意义[J].现代检验医学杂志,2015,30(06):32-34.[doi:10.3969/j.issn.1671-7414.2015.06.009]
　DANG Shana,ZHOU Jiana,YANG Fanb,et al.Expression of Hypoxia Inducible Factor 2α in Pancreatic Carcinoma and Its Clinical Significance[J].Journal of Modern Laboratory Medicine,2015,30(06):32-34.[doi:10.3969/j.issn.1671-7414.2015.06.009]
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胰腺癌组织中缺氧诱导因子-2α的表达及临床意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第30卷
期数:
2015年06期
页码:
32-34
栏目:
论著
出版日期:
2015-12-30

文章信息/Info

Title:
Expression of Hypoxia Inducible Factor 2α in Pancreatic Carcinoma and Its Clinical Significance
作者:
党珊1a; 周健1a; 杨帆1b; 周家琛2; 易黙1a; 史丽萍1a
1.陕西省人民医院 a.消化内二科；b.泌尿科，西安710068；2.大连医科大学，辽宁大连116044
Author(s):
DANG Shan1a; ZHOU Jian1a; YANG Fan1b; ZHOU Jia-chen2; YI Mo1a;  SHI Li-ping1a
1a.the Second Department of Gastroenterology; 1b.Department of Urology，Shaanxi Provincial People’s Hospital， Xi’an 710068，China；2.Dalian Medical University，Liaoning Dalian 116044，China
关键词:
胰腺癌; 缺氧诱导因子-2α
分类号:
R735.9；R730.43
DOI:
10.3969/j.issn.1671-7414.2015.06.009
文献标志码:
A
摘要:
目的探讨胰腺癌中缺氧诱导因子-2α(HIF-2α)的表达，并观察HIF-2α的表达对患者预后生存的影响。方法选取62例胰腺癌标本，采用免疫组织化学方法对胰腺癌组织中的HIF-2α表达进行检测，分析其与临床病理特征及预后生存的关系。结果32例胰腺癌组织HIF-2α表达阳性，阳性表达率51.6%(32/62)。10例正常胰腺组织HIF-2α表达均阴性。HIF-2α阳性表达于细胞质。HIF-2α在胰腺癌组织中的表达与肿瘤TNM分期、血管侵犯有关，差异具有统计学意义(χ2=6.452，4.089；P均<0.05)，而HIF-2α在胰腺癌组织中的表达与性别、年龄、肿瘤部位、肿瘤大小、淋巴结转移、组织学分级无关，差异无统计学意义(χ2=0.008，0.001，0.518，1.004，2.325，1.617；P均>0.05)。胰腺癌中HIF-2α阴性组病例3年生存率为30%，而HIF-2α阳性组病例3年生存率为6.25%，两组之间差异具有统计学意义(χ2=5.984，P<0.05)。结论HIF-2α在胰腺癌组织中高表达可能与肿瘤发生、发展密切相关，HIF-2α有望成为胰腺癌新的治疗靶点和预后标志物。
Abstract:
ObjectiveTo investigate the expression of hypoxia inducible factor alpha-2(HIF-2α) in pancreatic cancer，and to observe the effect of HIF-2α on prognosis．MethodsThe expression of HIF-2α in 62 pancreatic carcinoma specimen were detected by immunohistochemical method，and their relationships with clinicopathologic characteristics and prognosis of human pancreatic carcinoma were analyzed．ResultsThe positive expression rate in pancreatic carcinoma specimen was 51.6%，while there was no positive expression in 10 normal pancreatic specimen．HIF-2α positive expression in cytoplasm．The expression of HIF-2α in pancreatic cancer was associated with TNM staging and vascular invision，the difference was statistically significant (χ2=6.452，4.089；P<0.05)，however there was nosignificant correlation between the expression of HIF-2α in pancreatic cancer with sex，age，tumor location，tumor size，lymph node metastasis and histological grade (χ2=0.008，0.001，0.518，1.004，2.325，1.617；P>0.05)．3 year survival rate of HIF-2α negative patients was 30%，and that of HIF-2α positive patients was 6.25%，the difference was statistically significant between the two groups (χ2=5.984，P<0.05)．ConclusionThe high expression of HIF-2αin pancreatic cancer is closely related with carcinogenesis and aggression，and it can be used as a new therapeutic target and prognostic marker of pancreatic carcinoma．

参考文献/References:

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备注/Memo

备注/Memo:
基金项目：陕西省2012科技计划项目(NO.2012K13-01-14)。 作者简介：党珊(1980-)，女，硕士，副主任医师，主要从事消化系统疾病的诊治和研究，E-mail：brightsandy@126.com。
更新日期/Last Update: 1900-01-01