[1]党小军,张华,王欣.人附睾蛋白4(HE4)在乳腺癌诊断中的价值[J].现代检验医学杂志,2015,30(06):84-85.[doi:10.3969/j.issn.1671-7414.2015.06.024]
 DANG Xiao-jun,ZHANG Hua,WANG Xin.Value of Human Epididymis Protein 4(HE4) in Diagnosis of Breast Cancer[J].Journal of Modern Laboratory Medicine,2015,30(06):84-85.[doi:10.3969/j.issn.1671-7414.2015.06.024]
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人附睾蛋白4(HE4)在乳腺癌诊断中的价值()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第30卷
期数:
2015年06期
页码:
84-85
栏目:
论著
出版日期:
2015-12-30

文章信息/Info

Title:
Value of Human Epididymis Protein 4(HE4) in Diagnosis of Breast Cancer
作者:
党小军1张华1王欣2
1.陕西省人民医院检验科,西安710068; 2.陕西省核工业215医院检验科,陕西咸阳712000
Author(s):
DANG Xiao-jun1ZHANG Hua1WANG Xin2
1.Department of Clinical Laboratory, Shaanxi Provincial People’s Hospital,Xi’an 710068,China;2.Department of Clinical Laboratory, Nuclear Industry 215 Hospital of Shaanxi Province,Shaanxi Xianyang 712000,China
关键词:
人附睾蛋白糖链抗原乳腺癌
分类号:
R737.9;R730.43
DOI:
10.3969/j.issn.1671-7414.2015.06.024
文献标志码:
A
摘要:
目的探讨血清中人附睾蛋白4(HE4)在辅助诊断乳腺癌中的临床价值。方法收集73例乳腺癌患者(I,II期患者28例,III,IV期患者45例,年龄31~60岁,平均年龄为45.7岁)、62例乳腺良性疾病患者(年龄23~65岁,平均年龄为41.1岁)及50例女性正常对照人群(年龄为28~60岁,平均年龄为40.2岁)的血清,用电化学发光法检测血清CA153和HE4的含量。结果正常对照组HE4 (81.5±34.5 pg/L)和乳腺良性疾病组HE4 (87.0±38.0 pg/L)分别与乳腺癌组HE4(213.4±136.5 pg/L)结果进行比较,差异均有统计学显著性意义(t=3.442,3.016;P<0.01);正常对照组和乳腺良性疾病组比较差异无统计学意义(t=0.779,P>0.05)。在乳腺癌患者中CA153的敏感度(43.8%)高于HE4(37.0%),而特异度则是HE4(68.70%)高于CA153(66.95%),将HE4与CA153联合检测,其敏感度(52.0%)与特异度(70.59%)均高于单独检测。结论HE4在乳腺癌中有一定程度的表达,具有临床价值,HE4与CA153联合检测,检出率会有所提高。
Abstract:
ObjectiveTo investigate the clinical value of serum human epididymis protein 4 (HE4) in diagnosis of breast cancer.MethodsCollected with serum of 73 cases of breast cancer patients (38 cases of stage I and II patients,35 patients with stage III and IV,31~60 years old,average age for 45.7 years),62 cases of benign breast disease patients (aged from 23 to 65 years,mean age was 41.1 years) and 50 cases of female normal control groups (age for 28~60 years,average age was 40.2 years) and detected the contents of CA153 and HE4 in the serum by electrochemiluminescence assay.ResultsThere were significant difference (t=3.442,3.016,P<0.01) between normal control group (81.5±34.5 pg/L) / benign breast disease group (87.0±38.0 pg/L) and breast cancer group (213.4±136.5 pg/L) compared with the HE4 results of them and having statistical significance.But normal control group and breast benign disease group had no statistical significance (t=0.779,P>0.05).In patients with breast cancer the sensitivity of CA153 (43.8%) was higher than that of HE4 (37.0%),but the specificity of HE4 (68.70%) was higher than that of CA153 (66.95%).Combined detection of HE4 and CA153,its sensitivity (52.0%) and specificity (70.59%) were higher than that of single detection.ConclusionHE4 had a certain degree of expression in breast cancer,and it has clinical value.Combined detection of HE4 and CA153,the detection rate can be improved.

参考文献/References:

[1]Jemal A,Bray F,Center MM,et al.Global cancer sta-tistics[J].CA Cancer J Clin,2011,61(2):69-90.
[2]孙萍,陈光意,陈晓香.CA153及CA125联合检测在乳腺癌诊断中的意义[J].中国实用医刊,2011,38(2):32-33. Sun P,Chen GY,Chen XX.Significance of combined detection of CA153 and CA125 in diagnosis of breast cancer[J].Chinese Journal of Practical Medicine,2011,38(2):32-33.
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[5]朱自力,戴伟萍,肖春红,等.血清HE4,CA125联合ROMA指数在卵巢癌预测和诊断中的应用价值[J].现代检验医学杂志,2014,29(2):76-77,80. Zhu ZL,Dai WP,Xiao CH,et al.Value of combined assays of human epididymis protein4,CA125 and ROMA index in patients with ovarian cancer[J].Journal of Modern Laboratory Medicine,2014,29(2):76-77,80.
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备注/Memo

备注/Memo:
作者简介:党小军(1971-),男,副主任技师,长期从事免疫学临床检验及科研工作,Tel:13891928992,E-mail:DXJ2323@126.com。
更新日期/Last Update: 1900-01-01