[1]谭婷婷,程 莉,魏红霞,等.尿α1-酸性糖蛋白在早期糖尿病肾病诊断中的应用价值[J].现代检验医学杂志,2016,31(01):80-82.[doi:10.3969/j.issn.1671-7414.2016.01.023]
　TAN Ting-ting,CHENG Li,WEI Hong-xia,et al.Value of Urinary α1-Acid Glycoprotein in Early Diagnosis of Diabetic Nephropathy[J].Journal of Modern Laboratory Medicine,2016,31(01):80-82.[doi:10.3969/j.issn.1671-7414.2016.01.023]
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尿α1-酸性糖蛋白在早期糖尿病肾病诊断中的应用价值()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年01期
页码:
80-82
栏目:
论著
出版日期:
2016-01-25

文章信息/Info

Title:
Value of Urinary α1-Acid Glycoprotein in Early Diagnosis of Diabetic Nephropathy
作者:
谭婷婷; 程 莉; 魏红霞; 张 葵
南京大学医学院附属鼓楼医院检验科,南京 210008
Author(s):
TAN Ting-ting; CHENG Li; WEI Hong-xia; ZHANG Kui
Department of Medical Laboratory,Drum Tower Hospital Affiliated to Medical School of Nanjing University,Nanjing 210008,China
关键词:
糖尿病;  α1-酸性糖蛋白;  糖尿病肾病
分类号:
R587.2; R446.112
DOI:
10.3969/j.issn.1671-7414.2016.01.023
文献标志码:
A
摘要:
目的 探讨尿α1-酸性糖蛋白(AAG)在早期糖尿病肾病(DN)诊断中的应用价值。方法 选取2013年5月～2014年10月南京大学医学院附属鼓楼医院诊治的2型糖尿病(T2DM)患者266例,根据尿微量清蛋白/肌酐(ACR)水平,将患者分为单纯糖尿病组(Non-DN)152例和糖尿病肾病组(DN)114例,其中DN组包括低尿微量清蛋白/肌酐组(LUA)49例,高尿微量清蛋白/肌酐组(HUA)32例和极高尿微量清蛋白/肌酐组(VHUA)33例。选取健康体检者63例为正常对照组(NC),骨折患者66例为应激对照组。测定尿AAG及各项生化指标。结果 DN组尿AAG水平明显高于应激对照组、Non-DN组和NC组,差异具有统计学意义(t=7.951,7.985和8.021,P均<0.05); 随DN病程进展,尿AAG水平从LUA组、HUA组到VHUA组呈依次递增趋势,各组间差异具有统计学意义(P<0.05)。尿AAG与血尿酸、血肌酐、C-反应蛋白和ACR均呈正相关(r=0.169,0.286,0.373和0.606,P均<0.01)。逐步Logistic回归分析表明尿AAG是DN的独立危险因素(P<0.05)。结论 尿AAG在早期DN诊断和监测病程进展等方面具有良好的应用前景。
Abstract:
Objective To investigate the clinical value ofurinary α1-acid glycoprotein(AAG)in the early diagnosis of diabetic nephropathy(DN).Methods 266 cases of diabetic patients in Drum Tower Hospital Affiliated to Medical School of Nanjing University from May 2013 to October 2014 were recruited,and patients were divided into four groups basedon the urine albumin/creatinine(ACR)levels,as follows:non-diabetic nephropathy group(Non-DN)152 cases,low urinary albumin/creatinine group(LUA)49 cases,high urinary albumin/creatinine group(HUA)32 cases,and very high urinaryalbumin/creatinine group(VHUA)33 cases.63 cases of healthy subjects(NC group)and 66 cases of fracture patients(stress group)were recruited as control group.The urinary AAG and other biochemical indicators were measured for all subjects.Results The level of urinary AAG in DN group was significantly higher than that in stress group,Non-DN group and NC group(t=7.951,7.985,8.021,P<0.05),and gradually increased from LUA,HUA to VHUA group(P<0.05).The urinary AAG level was positively correlated with UA,Cr,CRP and ACR(r=0.169,0.286,0.373,0.606,P<0.01).Stepwise logisticregression analysis showed that the urinary AAG was the independent risk factorof DN(P<0.05).Conclusion The level of urinary AAGhas good application value in the early diagnosis and monitoring progression ofDN.

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备注/Memo

备注/Memo:
基金项目:南京市科技发展重点项目(ZKX09030)。 作者简介:谭婷婷(1986-),女,硕士,技师,主要从事临床生化检验,E-mail:trxtt@126.com。 通讯作者:张 葵(1961-),女,硕士,主任技师,E-mail:13505151066@163.com。
更新日期/Last Update: 2016-01-20