[1]张 蕾,任亚女,曾婷婷,等.晚期非小细胞肺癌患者血液实验指标和病理分期等因素对生存时间的影响分析[J].现代检验医学杂志,2016,31(02):83-86.[doi:10.3969/j.issn.1671-7414.2016.02.025]
　ZHANG Lei,REN Ya-n,ZENG Ting-ting,et al.Analysis of Prognosis Related Factors in Patients with Advanced Non-Small Cell Lung Cancer[J].Journal of Modern Laboratory Medicine,2016,31(02):83-86.[doi:10.3969/j.issn.1671-7414.2016.02.025]
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晚期非小细胞肺癌患者血液实验指标和病理分期等因素对生存时间的影响分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年02期
页码:
83-86
栏目:
论著
出版日期:
2016-06-01

文章信息/Info

Title:
Analysis of Prognosis Related Factors in Patients with Advanced Non-Small Cell Lung Cancer
作者:
张 蕾; 任亚女; 曾婷婷; 粟 军
四川大学华西医院实验医学科,成都 610041
Author(s):
ZHANG Lei; REN Ya-nü; ZENG Ting-ting; SU Jun
Department of Laboratory Medicine,West China Hospital of Sichuan University,Chengdu 610041,China
关键词:
非小细胞肺癌;  生存时间;  纤维蛋白原
分类号:
R734.2; R730.43
DOI:
10.3969/j.issn.1671-7414.2016.02.025
文献标志码:
A
摘要:
目的 探讨影响晚期非小细胞肺癌预后的相关因素。方法 回顾性分析118例晚期非小细胞肺癌患者的临床资料,分析影响其预后的相关因素。结果 ①单因素分析:患者年龄37～79岁,中位值为60岁,低年龄组(≤60岁)和高年龄组(>60岁)中位生存期分别为641天和513天(P=0.015); 纤维蛋白原为1.99～9.99 g/L,中位值为4.00 g/L,低纤维蛋白原组(≤4.00 g/L)和高纤维蛋白原组(>4.00 g/L)中位生存期分别为692天和421天(P=0.005); 病理类型:腺癌、鳞癌、腺鳞癌中位生存期依次递减(P=0.020); PS评分越高,中位生存期越短(P=0.018); 性别、PLRNLR,T/N分期,CYFRA21-1,吸烟对晚期非小细胞肺癌患者生存时间的影响差异无统计学意义。②通过 Cox回归分析进行多因素分析,仅纤维蛋白原为影响晚期非小细胞肺癌预后的独立因素。结论 单因素分析显示年龄、纤维蛋白原、PS评分和病理类型对于晚期非小细胞肺癌预后有影响,且年龄、纤维蛋白原、PS评分与预后生存期呈负相关,腺癌的生存时间较鳞癌和腺鳞癌长; 多因素Cox分析提示纤维蛋白原是影响晚期非小细胞肺癌预后的独立危险因素,且纤维蛋白原越高,预后越差。
Abstract:
Objective To investigate the related factors which affect the prognosis of advanced non-small cell lung cancer.Methods 118 patients with advanced non-small cell lung cancer were involved in a retrospective analysis and clinical data were analyzed.Results ① Univariate analysis showed that the median survival time ofthe younger(≤60)and older age group(>60)were 641 days and 513 days,respectively(P=0.015)(patients age 37～79 years old,median age 60 years old).Low fibrinogen group(≤4.00 g/L)and high fibrinogen group(>4.00 g/L)in median survival were 692 days and 421 days(P=0.005),respectively(fibrinogen 1.99～9.99 g/L,median value 4.00 g/L).The median survival time of adenocarcinoma,squamous cell carcinoma,adenosquamous carcinoma were in a descending order(P=0.020); Patients with higher PS score had shorter median survival time(P=0.018); Gender,PLR,NLR,T/N staging,CYFRA21-1 and smokinghad no impact on lung cancer patients with advanced non-small cell survival time.②Cox regression analysis showed that fibrinogen was the only independent factors affecting advanced non-small cell lung cancer prognosis.Conclusion Univariate analysis showed that age,fibrinogen,PS score andhistological type were affected factors of advanced non-small cell lung cancerprognosis.Age,fibrinogen and PS score were negatively correlated with survivaltime.Adenocarcinoma had longer median survival than squamous cell carcinoma and adenosquamous carcinoma.Multivariate Cox analysis showed that fibrinogen is an independent risk factor affecting advanced non-small cell lung cancer prognosis,patients with higher concentration of fibrinogen had worse prognosis.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金青年科学基金项目(No.81301493)。 作者简介:张 蕾(1991-),女,学士,技师,Tel:18302805115,E-mail:372144045@qq.com。 任亚女,女,本科学历,E-mail:ryn0226@163.com,同为第一作者。 通讯作者:粟 军,女,主任技师,研究方向:临床血液学,E-mail:sjhuaxi1667@163.com。
更新日期/Last Update: 2016-02-20