[1]薛 丽,黄 芳,张彦平,等.丙肝患者血清HCV-RNA含量与肝功能及血常规指标的相关性[J].现代检验医学杂志,2017,32(05):110-114.[doi:10.3969/j.issn.1671-7414.2017.05.017]
　XUE Li,HUANG Fang,ZHANG Yan-ping,et al.Relevance of Serum HCV-RNA Level with Routine Liver Function Indices and Blood Routine Parameters in Patients with Hepatitis C[J].Journal of Modern Laboratory Medicine,2017,32(05):110-114.[doi:10.3969/j.issn.1671-7414.2017.05.017]
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丙肝患者血清HCV-RNA含量与肝功能及血常规指标的相关性()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第32卷
期数:
2017年05期
页码:
110-114
栏目:
论著
出版日期:
2017-11-02

文章信息/Info

Title:
Relevance of Serum HCV-RNA Level with Routine Liver Function Indices and Blood Routine Parameters in Patients with Hepatitis C
文章编号:
1671-7414(2017)05-110-05
作者:
薛 丽1; 黄 芳1; 张彦平1; 雷 娜1; 王 妍1; 魏 伟1; 黎 明2; 李步荣1; 耿 燕1
1.西安交通大学医学院第二附属医院检验科,西安 710004; 2.西安交通大学医学院第一附属医院心血管外科,西安 710061
Author(s):
XUE Li1; HUANG Fang1; ZHANG Yan-ping1; LEI Na1; WANG Yan1; WEI wei1;  LI Ming2; LI Bu-rong1; GENG Yan1
1.Department of Clinical Laboratory, the Second Affiliated Hospital of Xi'an Jiaotong University Medical College, Xi'an 710004,China; 2.Department of Cardiovascular Surgery,the First Affiliated Hospital of Xi'an Jiaotong University Medical College,Xi'an 710061,China
关键词:
丙型肝炎;  HCV-RNA 含量;  肝功能指标;  血细胞计数参数
分类号:
R512.63; R446.112
DOI:
10.3969/j.issn.1671-7414.2017.05.017
文献标志码:
A
摘要:
目的 探讨丙肝患者血清HCV-RNA含量与肝功能和血常规指标的相关性,为丙肝患者早期诊断和治疗效果监测提供参考依据。方法 选取丙肝患者651例,应用实时荧光定量PCR法检测血清HCV-RNA含量。根据血清HCV-RNA 含量分为六组,分析患者血清HCV-RNA含量与肝功能和血常规指标的关系。结果 随着丙肝患者血清HCV-RNA含量增加,血清丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST),AST/ALT,谷氨酰基转移酶(GGT)和总胆红素(TBIL)均呈升高趋势,而清蛋白/球蛋白比值(A/G)呈下降趋势(ALT,AST,AST/ALT,GGT,TBIL和A/G的最低值与最高值分别是32.3±9.7 U/L与96.2±13.6 U/L,31.1±8.38 U/L与113.5±15.9U/L,0.86±0.09与1.19±0.11,29.2±14.5 U/L与52.7±16.2 U/L,17.2±4.32 μmol/L与26.0±5.58 μmol/L,0.98±0.07与1.35±0.14),差异有统计学意义(F=457.1,656.4,149.1,40.18,46.56和146.98,均P<0.01)。血细胞计数结果显示,随着血清HCV-RNA含量增加,白细胞(WBC)、中性粒细胞比值(NEUT%)、红细胞(RBC)、血红蛋白(Hb)和血小板(PLT)呈下降趋势而淋巴细胞比值(LY%)呈上升趋势[WBC,NEUT%,LY%,RBC,Hb和PLT的最低值与最高值分别是(4.30±0.22)×109/L与(6.02±0.27)×109/L,(48.13±3.56)%与(59.28±3.40)%,(31.05±3.41)%与(38.81±4.65)%,(3.73±1.70)×1012/L与(4.65±1.88)×1012/L,(122.01±5.58)g/L与(135.37±8.50)g/L,(102.65±16.87)×109/L与(148.21±14.40)×109/L],除RBC的差异无统计学意义(F=1.926,P>0.05),WBC,NEUT%,LY%,Hb和PLT的差异均具有统计学意义(F=349.0,132.145,43.65,38.91和52.21,均P<0.01)。结论 丙肝患者肝功能和血细胞计数指标与血清HCV-RNA含量有关,联合检测血清HCV-RNA含量与肝功能和血细胞计数指标对丙型肝炎的诊断及疗效观察有指导意义。
Abstract:
Abstract:Objective To explore the correlation of serum HCV-RNA level with liver function indices and blood routine parameters in patients with hepatitis C,and provide the references for the early diagnosis and monitoring the prognosis of hepatitis C.Methods The study population comprised 651 patients who were diagnosed with hepatitis C in the Second Affiliated Hospital of Medical College of Xi'an Jiaotong University.Serum level of HCV RNA was determined by quantitative real-time polymerase chainreaction(real-time PCR).The data obtained were divided into six groups according to the result of HCV RNA level.Then the correlation of serum HCV-RNA levelwith liver function indices and blood routine parameters was analyzed.Results With the rising level of serum HCV-RNA,the levels of liver function indices including ALT,AST,AST/ALT,GGT and TBIL were all significant increased in hepatitis C patients.However,A/G presented a declining trendwith the increase of serum HCV-RNA level.The lowest value and highest value ofALT,AST,AST/ALT,GGT,TBIL and A/G were 32.3±9.7 U/L and 96.2±13.6 U/L,31.1±8.38 U/L and 113.5±15.9 U/L,0.86±0.09 and 1.19±0.11,29.2±14.5 U/L and 52.7±16.2 U/L,17.2±4.32 μmol/L and 26.0±5.58 μmol/L,0.98±0.07 and 1.35±0.14,respectively.Significant differences in ALT,AST,AST/ALT,GGT,TBIL and A/G were observed among these groups(F value was 457.1,656.4,149.1,40.18,46.56 and 146.98,respectively.all P<0.01).Moreover,the levels of blood routine parameters including WBC,NEUT%,RBC,Hb and PLT were all significant decreased while that of LY% was increased with the rising level of serum HCV-RNA in hepatitis C patients.The lowest value andhighest value of WBC,NEUT%,LY%,RBC,Hb and PLT were(4.30±0.22)×109/Land(6.02±0.27)×109/L,(48.13±3.56)% and(59.28±3.40)%,(31.05±3.41)% and(38.81±4.65)%,(3.73±1.70)×1012/L and(4.65±1.88)×1012/L,(122.01±5.58)g/L and(135.37±8.50)g/L,(102.65±16.87)×109/L and(148.21±14.40)×109/L,respectively.There was no significant difference in RBC among groups(F=1.926,all P<0.05).However,the differences in other blood routine parameters than RBC among groups were statistically significant(F value of WBC,NEUT%,LY%,Hb and PLT was 349.0,132.145,43.65,38.91 and 52.21,respectively.all P<0.01).ConclusionSerum HCV-RNA level was correlated with routine liver function indices and blood routine parameters.It is important to perform the combined detection of serum HCV-RNA level,routine liver function indices and blood routine parameters in hepatitis C patients,which can help to guide diagnosis and to evaluate the prognosis.

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备注/Memo

备注/Memo:
基金项目:中央高校基本科研业务经费(No.xjj2016109)。 作者简介:薛 丽,女,博士,主管技师,主要从事分子生物学检验工作,E-mail:xuelially@163.com。 通讯作者:耿 燕,E-mail:gengyanjyk@126.com。
更新日期/Last Update: 1900-01-01