[1]左江成a,邓琛琛a,杨　洁a,等.湖北宜昌市育龄妇女和母婴巨细胞病毒感染现状调查及感染风险评估[J].现代检验医学杂志,2020,35(06):91-94.[doi:doi:10.3969/j.issn.1671-7414.2020.06.022]
　ZUO Jiang-cheng a,DENG Chen-chen a,YANG Jie a,et al.Investigation on Status and Risk Assessment of Cytomegalovirus Infection inWomen of Childbearing Age and Maternals and Infants in Yichang, Hubei[J].Journal of Modern Laboratory Medicine,2020,35(06):91-94.[doi:doi:10.3969/j.issn.1671-7414.2020.06.022]
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湖北宜昌市育龄妇女和母婴巨细胞病毒感染现状调查及感染风险评估()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年06期
页码:
91-94
栏目:
论著
出版日期:
2020-12-30

文章信息/Info

Title:
Investigation on Status and Risk Assessment of Cytomegalovirus Infection inWomen of Childbearing Age and Maternals and Infants in Yichang, Hubei
文章编号:
1671-7414（2020）06-091-05
作者:
左江成a ; 邓琛琛a ; 杨　洁a ; 谭艳蓉a ; 李子豪a ; 杨金华b
（宜昌市夷陵区妇幼保健院 a. 检验科；b. 孕产保健科 , 湖北宜昌 443100）
Author(s):
ZUO Jiang-cheng a ;  DENG Chen-chen a ; YANG Jie a ; TAN Yan-rong a ;  LI Zi-hao a ;  YANG Jin-hua b
(a. Departement of Medical Laboratory; b. Department of Obstetrics and Gynecology, Maternal and Child Health Hospitalof Yiling District, Hubei Yichang 443100,China)
关键词:
育龄妇女; 婴儿; 人巨细胞病毒; 感染; 风险评估
分类号:
R373.1；R446
DOI:
doi:10.3969/j.issn.1671-7414.2020.06.022
文献标志码:
A
摘要:
目的　调查宜昌市育龄妇女和母婴巨细胞病毒（cytomegalovirus, CMV）感染现状，并评估孕产妇及婴儿的感染风险。方法　2015 年 7 月至 2018 年 12 月，应用 ELISA 检测 4 802 例非妊娠妇女、6 102 例孕妇、1 342 例婴儿血清 CMV-IgG/IgM 抗体和部分样本的 IgG 抗体亲和力；荧光定量 PCR（FQ-PCR）检测 1 671 例婴儿尿液和 / 或母乳中 CMV-DNA。结果　育龄妇女 CMV-IgG 阳性率为 96.8%，CMV-IgG 和 IgM 双抗体阳性率为 0.4%，妊娠与非妊娠妇女 CMV 抗体阳性率比较差异无统计学意义（χ 2 =0.001，P=0.979）。CMV 先天感染和围生期感染率分别为 0.1% 和 9.0%，围生期 CMV感染率高于先天性感染（χ 2 =85.138，P=0.00）。CMV-IgG 和 IgM 双抗体阳性的 18 例经 CMV-IgG 亲和力和 CMV-DNA检测，结合年龄推测 CMV 原发感染 6 例，复发感染 10 例，IgM 假阳性 2 例；核酸检测婴儿 CMV 感染率为 33.3%，新生儿，1~3 月龄和≥ 4 月龄组 CMV 感染率分别为 9.9%，51.2% 和 71.3%。在母乳 CMV-DNA 阳性组中，新生儿和婴儿CMV 感染率分别为 20.2% 和 74.6%，均高于母乳 CMV-DNA 阴性组新生儿 0.5% 和婴儿 42.9% 的感染率（χ 2 =33.592，P=0.000；χ 2 =10.559，P=0.001）。结论　宜昌市育龄妇女 CMV 感染率为 96.8%，妊娠没有增加 CMV 的感染风险。婴儿 CMV 感染率为 33.3%，感染随年龄的增加而增高。含 CMV 母乳是婴儿感染 CMV 的重要途径，出生一个月内进行适当干预是减少婴儿 CMV 感染的最佳时期。

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更新日期/Last Update: 2020-12-20