[1]张明威,洪 骏,戴 雯,等.脑脊液中性粒细胞与淋巴细胞比值(NLR)对神经外科开颅术后颅内感染的诊断价值[J].现代检验医学杂志,2021,36(03):7-9.[doi:10.3969/j.issn.1671-7414.2021.03.002]
 ZHANG Ming-wei,HONG Jun,DAI Wen,et al.Diagnostic Value of Ratio of Neutrophil to Lymphocyte in Patients withIntracranial Infection in Cerbrospinal Fluid after Craniotomy[J].Journal of Modern Laboratory Medicine,2021,36(03):7-9.[doi:10.3969/j.issn.1671-7414.2021.03.002]
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脑脊液中性粒细胞与淋巴细胞比值(NLR)对神经外科开颅术后颅内感染的诊断价值()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年03期
页码:
7-9
栏目:
论 著
出版日期:
2021-05-31

文章信息/Info

Title:
Diagnostic Value of Ratio of Neutrophil to Lymphocyte in Patients withIntracranial Infection in Cerbrospinal Fluid after Craniotomy
文章编号:
1671-7414(2021)03-007-04
作者:
张明威洪 骏戴 雯
(中国人民解放军东部战区总医院临床检验科,南京 210002)
Author(s):
ZHANG Ming-wei HONG Jun DAI Wen WU Jia TANG Hai-xia
(Department of Clinical Laboratory, General Hospital of Eastern Theater Command, Nanjing 210002, China)
关键词:
中性粒细胞与淋巴细胞比值脑脊液颅内感染
分类号:
R651.11;R446.14
DOI:
10.3969/j.issn.1671-7414.2021.03.002
文献标志码:
A
摘要:
目的 探讨脑脊液中性粒细胞与淋巴细胞比值(neutrophil and lymphocyte ratio,NLR)对神经外科开颅术后导致颅内感染患者的诊断价值。方法 选取在东部战区医院神经外科经过开颅术后,确诊颅内感染的患者 53 例,无颅内感染的患者 23 例,分别检测脑脊液和血液中白细胞计数 (WBC)、中性粒细胞百分比 (percentage of neutrophil,NEUT)、淋巴细胞百分比(percentage of lymphocyte,LYMPH)以及超敏 C 反应蛋白 (hs-CRP) 水平,比较两组患者的差异,并采用受试者工作特性曲线 (receiver operating curve, ROC) 比较各参数的诊断性能。结果 与非感染组相比较,感染组血液指标 WBC 和 NEUT 结果差异无统计学意义 (Z=-1.076,-1.629,均 P>0.05),LYMPH,NLR 以及 hs-CRP 结果差异有统计学意义 (Z=-2.054,-1.978,-2.370,均 P<0.05);而感染组脑脊液中 WBC, NEUT, LYMPH 以及 NRL 的差异均有统计学意义 (Z=-4.342,-2.882,-2.882,-2.882,P<0.05)。ROC 曲线显示,除 LYMPH 外,其它项目的 AUC 均大于70.0%,敏感度以 NEUT 最高,为 72.0%,特异度以 WBC 最高,为 92.9%。结论 脑脊液中 NLR 水平对开颅术后患者颅内感染的发生具有较好的临床诊断价值。

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金项目(81572074)。
作者简介:张明威(1988-),男,医学学士,技师,主要从事临床检验相关研究,E-mail:bbmchong@163.com。
通讯作者:唐海霞(1984-),女,医学硕士,主管技师,主要从事临床检验相关研究,E-mail:bbmchong@163.com。
更新日期/Last Update: 1900-01-01