[1]达晶,张超,吴红葵,等.急性心肌梗死患者血浆miRNA-423-5p 与整合素连接激酶水平表达对评价近期临床预后的价值[J].现代检验医学杂志,2020,35(05):33-37.[doi:10.3969/j.issn.1671-7414.2020.05.009]
　DA Jing,ZHANG Chao,WU Hong-kui,et al.Expression of Plasma miRNA-423-5p and Integrin-linked Kinase Levels in Patients with Acute Myocardial Infarction for Evaluating Recent Clinical Outcomes[J].Journal of Modern Laboratory Medicine,2020,35(05):33-37.[doi:10.3969/j.issn.1671-7414.2020.05.009]
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急性心肌梗死患者血浆miRNA-423-5p 与整合素连接激酶水平表达对评价近期临床预后的价值()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年05期
页码:
33-37
栏目:
论著
出版日期:
2020-11-01

文章信息/Info

Title:
Expression of Plasma miRNA-423-5p and Integrin-linked Kinase Levels in Patients with Acute Myocardial Infarction for Evaluating Recent Clinical Outcomes
文章编号:
1671-7414（2020）05-033-05
作者:
达晶1; 张超1; 吴红葵1; 刘刚1; 王文科1; 孙向阳2
1. 宝鸡市中心医院老年心脑血管病科，陕西宝鸡，721000；2. 达州市中心医院心内科，四川达州 635000
Author(s):
DA Jing 1; ZHANG Chao 1; WU Hong-kui 1; LIU Gang 1; WANG Wen-ke 1; SUN Xiang-yang 2
1.Department of Geriatric Cardio Cerebrovascular Disease, Baoji Central Hospital, Shaanxi Baoji 721000,China; 2. Department of Cardiology, Dazhou Central Hospital, Sichuan Dazhou 635000，China
关键词:
miRNA-423-5p; 整合素连接激酶; 急性心肌梗死
分类号:
R541；R446.11
DOI:
10.3969/j.issn.1671-7414.2020.05.009
文献标志码:
A
摘要:
目的　急性心肌梗死（acute myocardial infarction, AMI）患者血浆miRNA-423-5p 与整合素连接激酶水平表达 对评价近期临床预后的价值。方法　按照研究标准，从宝鸡市中心医院老年心脑血管病科2016 年1 月~2018 年1 月 收治患者中选取160 例作为研究对象，将80 例急性心肌梗死患者随机编入实验组，80 例稳定性心绞痛患者编入对照 组，开展临床研究分析。结合抽血检查结果分析患者的心肌酶谱（LDH,AST,CK 和ALT），心肌损伤（cTnl，Mb 和 CK-MB）指标，血浆miRNA-423-5p，利用酶联免疫法分析整合素连接激酶的表达水平，并在此基础上将实验组患者 编入高表达组与低表达组，分析心室重构情况及生活质量评分。结果　治疗后, 血浆miRNA-423-5p 相对表达量实验组 （0.6±0.2）高于对照组（0.3±0.1），差异具有统计学意义（t=12.000，P ＜ 0.05）；整合素连接激酶表达水平实验组 （3.2±0.4）高于对照组（1.8±0.1），差异具有统计学意义（t=30.370，P ＜ 0.05）；对照组心肌酶谱指标、心肌损伤 指标、心室重构指标和生活质量评分均优于观察组，两组差异具有统计学意义（t=0.043~102.176，均P ＜ 0.05）。结论　 血浆miRNA-423-5p 与整合素连接激酶均可作为急性心肌梗死近期预后监测的评估依据。
Abstract:
Objective　To evaluate the value of the expression of miRNA-423-5p and integrin linked kinase in patients with acute myocardial infarction(AMI). Methods　According to the research standard, 160 patients were selected from the Elderly Cardio Cerebrovascular Disease of Baoji Central Hospital from January 2016 to January 2018. 80 patients with (AMI) were randomly assigned to the experimental group and 80 patients with stable angina were assigned to the control group for clinical study and analysis. Combined with the results of blood sampling, the myocardial enzyme spectrum (LDH, AST, CK and ALT), myocardial injury (CTnl, MB and CK-MB), plasma miRNA-423-5p were analyzed. The expression level of integrin linked kinase was analyzed by enzyme-linked immunosorbent assay. On this basis, the patients in the experimental group were divided into high expression group and low expression group, and the ventricular remodeling and quality of life scores were analyzed. Results　 After treatment, the relative expression of miRNA-423-5p in the experimental group was 0.6±0.2, which was higher than that in the control group (0.3±0.1), and the difference was statistically significant (t = 12.000, P < 0.05). The expression level of integrin linked kinase in the experimental group was 3.2 ± 0.4，which was higher than that in the control group (1.8 ± 0.1),and the difference was statistically significant (t = 30.370, P < 0.05). The indexes of myocardial enzyme spectrum, myocardial injury, ventricular remodeling and quality of life in the control group were better than those in the observation group, and the difference was statistically significant (t=0.043~102.176, all P < 0.05). Conclusion　The plasma miRNA-423-5p and integrin linked kinase can be used as the evaluation basis for the short-term prognosis monitoring of AMI.

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备注/Memo

备注/Memo:
基金项目：四川省达州市科技局项目（项目编号201503）。
作者简介：达晶（1984-），女，硕士，主治医师，研究方向：急性心肌梗死基础与临床，E-mail：2797177362@qq.com。
通讯作者：孙向阳，男，硕士，副主任医师，研究方向: 急性心肌梗死基础与临床，E-mail：22514578@qq.com。
更新日期/Last Update: 2020-10-30