[1]刘　敏,李承红,刘　双,等.诱导痰 Galectin-3BP 及相关炎症因子水平检测在中性粒细胞型哮喘诊断中的价值[J].现代检验医学杂志,2020,35(06):56-58.[doi:doi:10.3969/j.issn.1671-7414.2020.06.014]
　LIU Min,LI Cheng-hong,LIU Shuang,et al.Value of Induced Sputum Galectin-3BP and Related InflammatoryFactors in the Diagnosis of Neutrophil Asthma[J].Journal of Modern Laboratory Medicine,2020,35(06):56-58.[doi:doi:10.3969/j.issn.1671-7414.2020.06.014]
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诱导痰 Galectin-3BP 及相关炎症因子水平检测在中性粒细胞型哮喘诊断中的价值()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年06期
页码:
56-58
栏目:
论著
出版日期:
2020-12-30

文章信息/Info

Title:
Value of Induced Sputum Galectin-3BP and Related InflammatoryFactors in the Diagnosis of Neutrophil Asthma
文章编号:
1671-7414（2020）06-056-04
作者:
刘　敏; 李承红; 刘　双; 王小江; 钟金男; 石　奕
（江汉大学附属医院武汉市第六医院呼吸内科，武汉 430015）
Author(s):
LIU Min;  LI Cheng-hong;  LIU Shuang;  WANG Xiao-jiang;  ZHONG Jin-nan;  SHI Yi
（Department of Respiratory Medicine,Wuhan No.6 Hospital, Affiliated Hospital of Jianghan University,Wuhan 430015,China）
关键词:
诱导痰; 半乳糖凝集素 -3 结合蛋白; 中性粒细胞型哮喘
分类号:
R562.25；R392.11
DOI:
doi:10.3969/j.issn.1671-7414.2020.06.014
文献标志码:
A
摘要:
目的　探讨诱导痰半乳糖凝集素 -3 结合蛋白（Galectin-3BP）及相关炎症因子水平检测在中性粒细胞型哮喘诊断中的价值。方法　选择 2018 年 10 月 ~2019 年 6 月江汉大学附属医院呼吸与危重症医学科收治的 65 例哮喘患者为研究对象，其中中性粒细胞型哮喘组（NA）27 例，嗜酸粒细胞型哮喘组 (EA)38 例，ELISA 法检测两组患者诱导痰Galectin-3BP 的表达水平，并分析 Galectin-3BP 与诱导痰炎症细胞及炎症因子的相关性。结果　NA 组诱导痰 Galectin-3BP 水平与 EA 组比较 (102.86 ±24.08ng/ml vs 64.02 ±18.93ng/ml)，差异有统计学意义（t= 47.314，P<0.05）。直线相关分析显示诱导痰 Galectin-3BP 与 IL-1β，IL-6 和 IL-8 均呈正相关（r=0.670，0.632 和 0.651, 均 P<0.001），与诱导痰中性粒细胞、巨噬细胞及淋巴细胞数均呈正相关（r=0.475，0.461 和 0.454, 均 P<0.05），与嗜酸性粒细胞数无明显相关性 (r=-0.219, P>0.05)。结论　诱导痰 Galectin-3BP 在 NA 患者中高表达，且与中性粒细胞相关炎症因子呈正相关，可作为 NA 的生物标志物。

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更新日期/Last Update: 2020-12-20