[1]尚天明,毕开湘.唾液 α- 突触核蛋白 (SNCA) 与嗅觉评估在帕金森病早期筛查中的应用研究[J].现代检验医学杂志,2020,35(06):95-97.[doi:doi:10.3969/j.issn.1671-7414.2020.06.023]
　SHANG Tian-ming,BI Kai-xiang.Application Research of Olfactory Assessment and Salivary SNCA in EarlyScreening of Parkinson’s Disease[J].Journal of Modern Laboratory Medicine,2020,35(06):95-97.[doi:doi:10.3969/j.issn.1671-7414.2020.06.023]
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唾液 α- 突触核蛋白 (SNCA) 与嗅觉评估在帕金森病早期筛查中的应用研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第35卷
期数:
2020年06期
页码:
95-97
栏目:
论著
出版日期:
2020-12-30

文章信息/Info

Title:
Application Research of Olfactory Assessment and Salivary SNCA in EarlyScreening of Parkinson’s Disease
文章编号:
1671-7414（2020）06-095-04
作者:
尚天明; 毕开湘
(宝鸡市康复医院精神科 , 陕西宝鸡 721000)
Author(s):
SHANG Tian-ming;  BI Kai-xiang
(Department of Psychiatry, Baoji Rehabilitation Hospital,Shaanxi Baoji 721000, China)
关键词:
嗅觉评估; 唾液 α- 突触核蛋白; 帕金森病; 早期筛查
分类号:
R744.6；R446.112
DOI:
doi:10.3969/j.issn.1671-7414.2020.06.023
文献标志码:
A
摘要:
目的　研究唾液 α- 突触核蛋白 (α-synuclein, SNCA) 与嗅觉评估在帕金森病 (parkinson’s disease, PD) 早期筛查中的应用。方法　选取宝鸡市康复医院 2018 年 2 月 ~2020 年 2 月 45 例 PD 患者为观察组，另选取同期 45 例体检健康者为对照组。比较两组的 16 种气味识别 (SS-16) 评分和唾液 SNCA。参照改良 H-Y 临床分级量表，将观察组 45 例 PD患者进一步分为早、中和晚期，分别比较不同分期患者的 SS-16 评分和唾液 SNCA。探究 PD 病情发展程度与 SS-16 评分和唾液 SNCA 的关系，采用受试者工作曲线 (ROC) 分析 SS-16 评分与唾液 SNCA 在 PD 早筛中的价值。结果　观察组的 SS-16 评分为 8.51±3.79 分，嗅觉障碍共 34 例，嗅觉障碍率为 75.56%，唾液 SNCA 为 1 272.13±38.52pg/ml。对照组的 SS-16 评分为 11.04±3.96 分，嗅觉障碍 11 例，嗅觉障碍率为 24.44%，唾液 SNCA 为 1 235.16±23.46pg/ml。两组的 SS-16 评分（t=3.096）、嗅觉障碍率（χ 2 =23.511）和唾液 SNCA（t=5.499）差异均具有统计学意义 ( 均 P <0.05)。不同程度 PD 患者 SS-16 评分（H=7.456）和唾液 SNCA（F=5.130）差异有统计学意义 ( P <0.05)。经 Spearman 秩相关分析显示 PD 病情发展程度与 SS-16 评分呈显著负相关关系 (r=-0.351， P =0.000)，其与唾液 SNCA 呈显著正相关关系(r=0.426， P =0.000)。ROC 分析结果显示 SS-16 评分和唾液 SNCA 联合检测概率判断早期 PD 的 AUC 为 0.807，显著高于 SS-16 评分（ P <0.05）和唾液 SNCA（ P <0.05）单项检测。结论　SS-16 评分和唾液 SNCA 与 PD 发生发展密切相关，联合检测 SS-16 评分和唾液 SNCA 有助于 PD 的早期筛查。

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更新日期/Last Update: 2020-12-20