[1]魏欣辉,刘　艳.老年糖尿病患者血清Irisin和PEDF水平检测在早期肾损伤风险筛查中的应用价值[J].现代检验医学杂志,2021,36(02):85-88.[doi:doi:10.3969/j.issn.1671-7414.2021.02.020]
　WEI Xin-hui,LIU Yan.Application Value of Serum Irisin and PEDF in Screening Early Renal Injury Risk in Elderly Patients with Diabetes Mellitus[J].Journal of Modern Laboratory Medicine,2021,36(02):85-88.[doi:doi:10.3969/j.issn.1671-7414.2021.02.020]
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老年糖尿病患者血清Irisin和PEDF水平检测在早期肾损伤风险筛查中的应用价值()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年02期
页码:
85-88
栏目:
论　著
出版日期:
2021-04-30

文章信息/Info

Title:
Application Value of Serum Irisin and PEDF in Screening Early Renal Injury Risk in Elderly Patients with Diabetes Mellitus
文章编号:
1671-7414（2021）02-085-05
作者:
魏欣辉; 刘　艳
（宝鸡市人民医院老年病科，陕西宝鸡 721000）
Author(s):
WEI Xin-hui;  LIU Yan
（Department of Geriatrics, Baoji People’s Hospital, Shaanxi Baoji 721000,China）
关键词:
血清鸢尾素; 血清色素上皮衍生因子; 老年糖尿病; 肾损伤
分类号:
R587.1；R392.11
DOI:
doi:10.3969/j.issn.1671-7414.2021.02.020
文献标志码:
A
摘要:
目的　研究老年糖尿病患者血清鸢尾素（Irisin）、色素上皮衍生因子（pigment epithelium-derived factor, PEDF）在早期肾损伤风险筛查中的应用价值。方法　收集2018年3月～2020年9月102例糖尿病患者，根据病情将102例患者分为A组（28例，单纯糖尿病）、B组[24例，早期糖尿病肾病（diabetic nephropathy, DN）]及C组（50例，临床DN）。比较三组血清Irisin和PEDF水平。根据肾小球滤过率（eGFR）是否<60ml/min·1.73 m2，记录肾损伤发生率。采用Cox风险回归模型分析糖尿病肾损伤的独立影响因素，以受试者工作曲线（receiver operating characteristic, ROC）分析血清Irisin，PEDF预测肾损伤的价值。结果　A，B和C三组患者血清Irisin，PEDF水平比较，差异均有统计学意义（F=34.47，48.64，均P<0.05）。102例糖尿病患者中，30例发生肾损伤，发生率为29.41%。血清Irisin（95%CI=0.24~0.65，HR=0.40，P<0.01）、血清PEDF（95%CI=1.77~2.30，HR=2.02，P<0.01）是老年糖尿病早期肾损伤的独立影响因素。血清Irisin和PEDF联合检测判断老年糖尿病患者发生肾损伤风险的AUC为0.77（95%CI=0.66~0.88，P<0.01），敏感度和特异度分别为0.85和0.59。结论　血清Irisin，PEDF参与老年糖尿病病理进程，血清Irisin与PEDF联合检测作为早期筛查老年糖尿病患者发生肾损伤风险的方法，敏感度高。

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备注/Memo

备注/Memo:
作者简介：魏欣辉（1983-），男，本科，主治医师，研究方向：内分泌，E-mail:baijweixinhui@163.com。
通讯作者：刘艳（1985-），女，本科，主治医师，研究方向：内分泌，E-mail：82896042@qq.com。
更新日期/Last Update: 2021-04-10