[1]顾园竹,张文静,查才军,等.B细胞激活因子~BAFF与抗磷脂综合征血栓形成关系的研究进展[J].现代检验医学杂志,2021,36(02):161-164.[doi:doi:10.3969/j.issn.1671-7414.2021.02.038]
 GU Yuan-zhu,ZHANG Wen-jing,ZHA Cai-jun,et al.Research Progress on the Relationship between B Cell Activating Factor (BAFF) and Thrombosis in Antiphospholipid Syndrome[J].Journal of Modern Laboratory Medicine,2021,36(02):161-164.[doi:doi:10.3969/j.issn.1671-7414.2021.02.038]
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B细胞激活因子~BAFF与抗磷脂综合征血栓形成关系的研究进展()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第36卷
期数:
2021年02期
页码:
161-164
栏目:
综 述
出版日期:
2021-04-30

文章信息/Info

Title:
Research Progress on the Relationship between B Cell Activating Factor (BAFF) and Thrombosis in Antiphospholipid Syndrome
文章编号:
1671-7414(2021)02-161-04
作者:
顾园竹张文静查才军
(哈尔滨医科大学附属第二医院检验科, 哈尔滨 150086)
Author(s):
GU Yuan-zhuZHANG Wen-jingZHA Cai-jun et al
(Department of Clinical Laboratory,the Sencond Affiliated Hospital of Harbin Medical University,Harbin 150086,China)
关键词:
B细胞激活因子(BAFF)抗磷脂综合征血栓形成
分类号:
R543;R392.11
DOI:
doi:10.3969/j.issn.1671-7414.2021.02.038
文献标志码:
A
摘要:
B细胞激活因子(B-cell activation factor,BAFF)在B细胞生长、发育和分化中起到关键作用,后者与抗体的产生密切相关,因而在自身免疫性疾病中被广泛研究。目前许多研究表明,BAFF与血栓事件的发生存在联系,而抗磷脂综合征(antiphospholipid syndrome,APS)是一种以反复动静脉血栓形成为表现的自身免疫性疾病,可见BAFF与抗磷脂综合征的关系值得深入研究。该文将从BAFF与抗磷脂综合征血栓形成“二次打击”学说的角度,概述其与抗磷脂综合征内皮细胞功能紊乱、炎症反应、动脉粥样硬化、血小板活化和补体激活的联系,为抗磷脂综合征血栓发生机制研究和临床药物靶向治疗提供参考。

参考文献/References:

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备注/Memo

备注/Memo:
作者简介:顾园竹(1994-),女,硕士在读,专业:临床检验诊断学,E-mail:gyz9400@163.com。
通讯作者:刘彦虹,Tel:0451-86605610,E-mail: liuusa2016@163.com。
更新日期/Last Update: 2021-04-10