[1]李文生,魏绪仓,严晓华,等.滤泡树突状细胞表达模式变化 在淋巴瘤病理鉴别诊断中的应用价值[J].现代检验医学杂志,2015,30(01):8-10.[doi:10.3969/j.issn.1671-7414.2015.01.003]
　LI Wen-sheng,WEI Xu-cang,YAN Xiao-hua,et al.Differential Diagnostic Value of Morphological Changes of Follicular Dendritic Cell Meshwork between Different Subtypes of Lymphoma[J].Journal of Modern Laboratory Medicine,2015,30(01):8-10.[doi:10.3969/j.issn.1671-7414.2015.01.003]
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滤泡树突状细胞表达模式变化 在淋巴瘤病理鉴别诊断中的应用价值()

《现代检验医学杂志》[ISSN:/CN:]

卷:
第30卷
期数:
2015年01期
页码:
8-10
栏目:
论著
出版日期:
2015-01-30

文章信息/Info

Title:
Differential Diagnostic Value of Morphological Changes of Follicular Dendritic Cell Meshwork between Different Subtypes of Lymphoma
文章编号:
1671-7414(2015)01-008-04
作者:
李文生,魏绪仓,严晓华,陈 琳,姜亚卓,马 钰,孙亚丽,王 华
陕西省人民医院,西安交通大学医学院第三附属医院,西安 710068
Author(s):
LI Wen-sheng,WEI Xu-cang,YAN Xiao-hua,CHEN Lin,JANG Ya-zhuo,MA Yu, SUN Ya-li,WANG Hua
Shaanxi Provincial People's Hospital,theThird Affiliated Hospital of Medical School,Xi'an Jiaotong University,Xi'an 710068,China
关键词:
滤泡树突状细胞网;  淋巴瘤;  病理诊断
分类号:
R733; R446.8
DOI:
10.3969/j.issn.1671-7414.2015.01.003
文献标志码:
A
摘要:
目的 探讨滤泡树突状细胞(follicular dendritic cell,FDC)网在各种类型淋巴瘤中的形态变化模式及其在鉴别诊断中的临床应用价值。方法 采用免疫组化方法对56例各种类型的淋巴瘤进行CD21免疫组化染色,观察FDC网的形态变化模式。其中包括弥漫大B细胞淋巴瘤8例、伯基特淋巴瘤2例、小淋巴细胞性淋巴瘤6例、浆细胞瘤6例、MALT淋巴瘤3例、外周T细胞淋巴瘤6例、间变性大细胞淋巴瘤5例、NK/T细胞淋巴瘤8例、滤泡性淋巴瘤4例、套细胞淋巴瘤3例、AITL 3例、FDC肉瘤2例。结果 FDC网在各种类型淋巴瘤中的形态变化可归为4种模式:①破坏消减型:绝大部分淋巴瘤FDC网完全或部分破坏,包括弥漫大B细胞淋巴瘤、伯基特淋巴瘤、小淋巴细胞性淋巴瘤、浆细胞瘤、外周T细胞淋巴瘤、间变性大细胞淋巴瘤、NK/T细胞淋巴瘤; ②存在型:FDC网存在,甚至有数量增多,包括MALT淋巴瘤、滤泡性淋巴瘤、套细胞淋巴瘤; ③增生紊乱型:FDC网增多、变形、紊乱,如AITL; ④全表达型:FDC网在肿瘤组织中每个细胞表达,如FDC肉瘤。结论 FDC在各种类型淋巴瘤中存在不同的形态变化模式,在淋巴瘤鉴别诊断中具有重要的临床应用价值。
Abstract:
Objective To explore the differentiated diagnostic value of the morphological changes of follicular dendritic cell(FDC)meshwork between different subtype of lymphoma.Methods CD21 was stained by immunohistochemistry(IHC)method,FDC meshwork pattern was studiedin 56 cases of various lymphomas(including 8 cases of diffuse large B cell lymphoma,2 cases of burkitts lymphoma,6 cases of small lymphocytic lymphoma,6 cases of plasmacytoma,3 cases of MALT lymphoma,6 cases of peripheral T cell lymphoma,3 cases of anaplastic large cell lymphoma,8 cases of NK/T cell lymphoma,4cases of follicular lymphoma,3 cases of mantle cell lymphoma,3 cases of AITL,2 cases of FDC sarcoma).Results FDC meshwork in the morphological changes of various subtypes of lymphoma could be classified into four patterns:①FDC form a disappeared and disintegrated meshwork,most of the lymphoma FDC meshwork fully or partially destroyed,including diffuse large B celllymphoma,burkitt lymphoma,small lymphocytic lymphoma,plasmacytoma,peripheral T cell lymphoma,anaplastic large cell lymphoma,NK/T cell lymphoma; ②FDC meshtwork existence,even hyperplasia,including follicular lymphoma,mantle cell lymphoma,MALT lymphoma; ③FDC meshtwork proliferation,disorder and deformation,such as AITL; ④Full expression subtype:such as FDC sarcoma.Conclusion The morphologic pattern of the FDC meshwork in lymphomas of follicular origin was differs according to the lymphoma subtypes,and it has important clinical value in lymphoma differential diagnostic.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目:陕西省科技攻关课题(No2010K12-02)。
作者简介:李文生(1968-),男,医学博士,主任医师,研究生导师,主要从事肿瘤病理及肿瘤生物研究工作。E-mail:liwensheng263@sohu.com。
更新日期/Last Update: 2015-01-30