参考文献/References:
[1] Woelk T,Sigismund S,Penengo L,et al.The ubiquitination code:a signalling problem[J].Cell Division,2007,2(1):11.
[2] Suryadinata R,Roesley SN,Yang G,et al.Mechanisms of generating polyubiquitin chains of different topology[J].Cells(Basel,Switzerland),2014,3(3):674-689.
[3] Hicke L,Schubert HL,Hill CP.Ubiquitin-binding domains[J].Nature Reviews Molecular Cell Biology,2005,6(8):610-621.
[4] Hurley JH,Lee S,Prag G.Ubiquitin-binding domains[J].Biochemical Journal,2006,399(3):361-372.
[5] Ikeda F,Crosetto N,Dikic I.What determines the specificity and outcomes of ubiquitin signaling?[J].Cell,2010,143(5):677-681.
[6] Song AX,Zhou CJ,Peng Y,et al.Structural transformation of the tandemubiquitin-interacting motifs in ataxin-3 and their cooperative interactions with ubiquitin chains[J].PLoS One,2010,5(10):e13202.
[7] Tyrrell A,Flick K,Kleiger G,et al.Physiologically relevant and portable tandem ubiquitin-binding domain stabilizes polyubiquitylated proteins[J].Proceedings of the National Academy of Sciences of the United States of America,2010,107(46):19796-19801.
[8] Winget JM,Mayor T.The diversity of ubiquitin recognition:hot spots andvaried specificity[J].Molecular Cell,2010,38(5):627-635.
[9] Dikic I,Wakatsuki S,Walters KJ.Ubiquitin-binding domains-from structures to functions[J].Nature Reviews Molecular Cell Biology,2009,10(10):659-671.
[10] Komander D,Rape M.The ubiquitin code[J].Annu Rev Biochem,2012(81):203-229.
[11] Rahighi S,Ikeda F,Kawasaki M,et al.Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappa B activation[J].Cell,2009,136(6):1098-1109.
[12] Bomar MG,D'souza S,Bienko M,et al.Unconventional ubiquitin recognition by the ubiquitin-binding motif within the Y family DNA polymerases iota andRev1[J].Molecular Cell,2010,37(3):408-417.
[13] Zhang DN,Chen T,Ziu I,et al.Together,Rpn10 and Dsk2 can serve as apolyubiquitin chain-length sensor[J].Molecular Cell,2009,36(6):1018-1033.
[14] Fushman D,Walker O.Exploring the linkage dependence of polyubiquitin conformations using molecular modeling[J].Journal of Molecular Biology,2010,395(4):803-814.
[15] Rahighi S,Ikeda F,Kawasaki M,et al.Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappa B activation[J].Cell,2009,136(6):1098-1109.
[16] Komander D,Reyes-turcu F,Licchesi JD,et al.Molecular discriminationof structurally equivalent Lys 63-linked and linear polyubiquitin chains[J].EMBO Reports,2009,10(5):466-473.
[17] Budhidarmo R,Day CL.The ubiquitin-associated domain of cellular inhibitor of apoptosis proteins facilitates ubiquitylation[J].Journal of Biological Chemistry,2014,289(37):25721-25736.
[18] Ortega Roldan JL,Casares S,Ringkjobing Jensen M,et al.Distinct ubiquitin binding modes exhibited by SH3 domains:molecular determinants and functional implications[J].PLoS One,2013,8(9):e73018.
[19] Liu J,Shaik S,Dai X,et al.Targeting the ubiquitin pathway for cancertreatment[J].Biochimicaet Biophysica Acta,2015,1855(1):50-60.
[20] Hoeller D,Dikic I.Targeting the ubiquitin system in cancer therapy[J].Nature,2009,458(7237):438-444.