[1]段发兰a,李亚新b,杨飞翔a,等.2型糖尿病患者血清铁代谢相关指标检测意义[J].现代检验医学杂志,2015,30(03):151-152.[doi:10.3969/j.issn.1671-7414.2015.03.046]
　Study on Iron Metabolism in Type Diabetes Patients.Study on Iron Metabolism in Type 2 Diabetes Patients[J].Journal of Modern Laboratory Medicine,2015,30(03):151-152.[doi:10.3969/j.issn.1671-7414.2015.03.046]
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2型糖尿病患者血清铁代谢相关指标检测意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第30卷
期数:
2015年03期
页码:
151-152
栏目:
检验与临床
出版日期:
2015-06-10

文章信息/Info

Title:
Study on Iron Metabolism in Type 2 Diabetes Patients
文章编号:
1671-7414(2015)03-151-03
作者:
段发兰a; 李亚新b; 杨飞翔a; 王 艳a
湖北医药学院附属东风医院 a.检验科; b.综合医疗科,湖北十堰 442000
Author(s):
Study on Iron Metabolism in Type 2 Diabetes Patients
a.Department of Clinical Laboratory;
b.Department of Geriatric, Dongfeng Hospital Affiliated to Medicine of Hubei University,Hubei Shiyan442008,China
关键词:
2型糖尿病;  铁调素;  铁蛋白;  转铁蛋白受体;  血清铁
分类号:
R587.1; R446.112
DOI:
10.3969/j.issn.1671-7414.2015.03.046
文献标志码:
A
摘要:
目的 探讨2型糖尿病患者血清铁调素(Hepcidin)、铁蛋白(SF)、转铁蛋白受体(sTfR)和血清铁(SI)的变化与临床意义。方法 130例2型糖尿病患者,分为两组,A组为微量蛋白尿组45例(mAlb30～300 mg/24 h),B组为正常蛋白尿组85例(mAlb＜30 mg/24 h),另选同期45例健康体检者为对照C组。各组均取空腹晨血5 ml离心取血清检测铁调素,SF,sTfR和SI含量。结果 A组患者血清铁调素和SF水平(42.27±32.12 ng/ml,211.6±107.2 ng/ml)均显著高于B组(26.12±18.36 ng/ml,179.1±109.7 ng/ml; P均＜0.05)和C组(9.47±1.65 ng/ml,84.41±47.10 ng/ml),(P均＜0.01); B组患者铁调素和SF水平显著高于C组(P均＜0.01)。各组之间SI水平(15.26 μmol/L,18.65 μmol/L,17.71 μmol/L)和sTfR水平(1.12 μg/L,1.05 μg/L,1.16 μg/L)差异均无统计学意义(t=0.469～1.176,P均＞0.05)。相关分析显示,2型糖尿病患者铁调素与SF呈显著正相关(r=0.329,P＜0.05),铁调素与sTfR,SI无显著相关性(r=0.169,P＞0.05; r=-0.149,P＞0.05)。结论 2型糖尿病患者体内存在以血清铁调素、SF增高为主的铁超负荷和铁代谢紊乱,并与尿微量清蛋白的排泄呈正相关。因此,检测血清铁调素和SF可作为糖尿病早期肾功能损伤的重要预测因子。
Abstract:
Objective To investigate the change and clinical significance of serum hepcidin,serum ferritin(SF),transferrin receptor(sTfR)and serum iron(SI)in patients in type 2 diabetes(T2DM).Methods130 patients with T2DM were divided into 2 groups according to the24 hour urine microalbumin(mAlb)quantitative:group A for trace microalbumin group 45 cases(mAlb30～300 mg/24 h),group B for normal albuminuria group of 85 cases,an alternate period of 45 cases of healthy physical examination for groupC(control group).Results Serum hepcidin and SF of groupA(42.27±32.12 ng/ml,211.6±107.2 ng/ml)were significantly higher than those in group B(26.12±18.36 ng/ml,179.1±109.7 ng/ml)and the healthy control group(P＜0.05),hepcidin and SF of group B was significantly higher than that of the control group(9.47±1.65 ng/ml,84.41±47.10 ng/ml,P＜0.01),SI and transferrin receptor(sTfR)has no statistical significance betweenthe three groups(P＞0.05).Correlation analysis showed that patients withtype 2 diabetes hepcidin was positively related with SF(P＜0.05),hepcidinand sTfR,SI had no significant correlation.Conclusion These results indicated that there existed serum hepcidin and SF increased ironoverload and iron metabolism disorder in type 2 diabetes.Therefore,detection of serum iron and SF can be used as a predictor of diabetes early renal damage.

参考文献/References:

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备注/Memo

备注/Memo:
作者简介:段发兰(1972-),女,本科,副主任技师,主要从事临床免疫检验工作,Tel:13972453082,E-mail:dfllhl@126.com。
通讯作者:李亚新,主任医师,Tel:13636255099,E-mail:lyx276@126.com。
更新日期/Last Update: 2015-06-10