[1]张灵玲,张朝明,谢国丽.中性粒VCS参数表达的性别差及差异表达的临床应用[J].现代检验医学杂志,2015,30(06):86-88.[doi:10.3969/j.issn.1671-7414.2015.06.025]
　ZHANG Ling-ling,ZHANG Chao-ming,XIE Guo-li.Gender Differences of Neutrophil VCS Parameter Expression and Clinical Application of Differential Expression[J].Journal of Modern Laboratory Medicine,2015,30(06):86-88.[doi:10.3969/j.issn.1671-7414.2015.06.025]
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中性粒VCS参数表达的性别差及差异表达的临床应用()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第30卷
期数:
2015年06期
页码:
86-88
栏目:
研究简报·实验技术
出版日期:
2015-12-30

文章信息/Info

Title:
Gender Differences of Neutrophil VCS Parameter Expression and Clinical Application of Differential Expression
作者:
张灵玲; 张朝明; 谢国丽
成都中医药大学附属医院检验科，成都610072
Author(s):
ZHANG Ling-ling; ZHANG Chao-ming; XIE Guo-li
Department of Clinical Laboratory，the Affiliated Hospital of Chengdu University of Traditional Chinese Medicine，Chengdu 610072，China
关键词:
VCS参数; 参考区间; 细菌感染; 急性髓系白血病; 差异表达
分类号:
R446.111
DOI:
10.3969/j.issn.1671-7414.2015.06.025
文献标志码:
A
摘要:
目的建立健康人群中性粒细胞体积、浆核比例、胞浆颗粒的参考区间并探讨其在细菌感染和急性髓系白血病中的应用。方法挑选2014年1～6月159例健康体检标本(男性79例，女性80例)，80例血液细菌感染标本和59例急性髓系白血病标本，统计分析健康男性与女性中性粒细胞VCS参数(MNV，MNC，MNS)的差异性并建立其参考区间；同时分析该指标在健康人群、细菌感染与急性髓系白血病中的表达差异性并分析原因。结果男性与女性中性粒细胞VCS参数MNV(fl)，MNC，MNS分别为140.1±7.9，161.5±4.5，155.7±6.5和140.3±7.6，162.9±3.8，155.3±9.7，采用独立样本t检验，两组间差异无统计学意义(t值分别为0.681，0.423和0.395，均P>0.05)，建立健康人群中性粒细胞VCS参数参考区间：MNV 140.2±7.7 fl，MNC 162.2±4.4，MNS 155.5±8.2；MNV(fl)，MNC，MNS在健康人、细菌感染和急性髓系白血病中的表达分别为140.2±7.7，162.2±4.4，155.5±8.2；168.3±13.7，154.2±5.5，133.2±11.1和180.1±13.9，150.9±10.7，125.1±17.1。采用非参数检验，三组间的差异有统计学意义(H值分别为58.683，43.101和37.536，均P<0.05)；健康人和细菌感染组间的差异具有统计学意义(z值分别为-6.545，-6.104和-4.325，均P<0.05)，健康人和急性髓系白血病组间的差异有统计学意义(z值分别为-5.337，-3.867和-5.264，均P<0.05)，但是细菌感染和急性髓系白血病组间的表达差异无统计学意义(z值分别为-0.843，-0.811和-1.177，均P>0.05)。结论中性粒细胞VCS参数的表达不受性别的影响，可作为一种快速、经济的临床筛检指标，提示细菌感染和白血病等疾病的存在。
Abstract:
ObjectiveTo establish the reference intervals of the neutrophil volume，nucleus-cytoplasm ratio and the granules of plasma in healthy subjects，and discuss its application in bacterial infection and acute myeloid leukemia．MethodsSelected 159 healthy specimens (including 79 males and 80 females)，80 cases of bacterial infections of the blood samples and 59 acute myeloid leukemia specimens from 2014 1～6 month．Analysed the difference of neutrophil VCS (MNV，MNC，MNS)expression between healthy male and female　and to established its reference intervals．At the same time，analysed the different expression of the index in healthy population　and bacterial infection，healthy people and acute myeloid leukemia，bacterial infection and　leukemia expression and analysed the reason．ResultsThe neutrophil VCS parameters (MNV，MNC，MNS) of male and female were 140.1±7.9 fl，161.5±4.5，155.7±6.5 and 140.3±7.6 fl，162.9±3.8，155.3±9.7 respectively．The difference between the two groups were not statistically significant(t value were 0.681，0.423 and 0.395，all P>0.05) by using the independent sample t test，then established the reference intervals of neutrophil VCS parameters：MNV 140.2±7.7 fl，MNC 162.2±4.4，MNS 155.5±8.2．The MNV(fl)，MNC，MNS level of healthy people，bacterial infection and leukemia were 140.2±7.7，162.2±4.4，155.5±8.2；168.3±13.7，154.2±5.5，133.2±11.1 and 180.1±13.9，150.9±10.7，125.1±17.1 respectively.The difference among the three groups was statistically significant(H value were 58.683，43.101 and 37.536，all P<0.05)，the difference between healthy people and patients was statistically significant (z valuewere -6.545，-6.104 and -4.325，all P<0.05)，the difference between healthy people and patients with leukemia was statistically significant (z value were -5.337，-3.867 and -5.264，all P<0.05)，but the difference in patients with acute myeloid leukemia and bacterial infection was not statistically significant (z value were -0.843，-0.811 and -1.177，all P>0.05) by using non-parametric test．ConclusionThe expression of neutrophil VCS parameters is not influenced by gender，that can be a kind of fast and economic clinical screening index to effectively filter bacterial infection and leukemia．

参考文献/References:

［1］李滔，张平安，梅冰，等．中性粒细胞VCS参数联合炎症标志物在脓毒血症早期诊断中的作用［Ｊ］．现代检验医学杂志，2013，28(3)：53-57，60． Li T，Zhang PA，Mei B，et al．Value of neutrophil VCS parameters combined with inflammatory biomarkers for early diagnosis of sepsis［J］．Journal of Modern Laboratory Medicine，2013，28(3)：53-57，60．
[2]王娜，乐家新，兰晓梅，等．白细胞VCS参数及多种细胞因子诊断细菌感染性疾病的探讨［Ｊ］．中华医院感染学杂志，2013，23(4)：740-742． Wang N，Lue JX，Lan XM，et al．Value of WBC，VCS parameters，C-reactive protein and inrerleukin-6 in diagnosis of bacterial infections［J］．Chinese Journal of Nosocomiology，2013，23(4)：740-742．
[3]Al-Gwaiz LA，Babay HH．The diagnostic value of absolute neutrophil count，band count and morphologic changes of neutrophils in predicting bacterial infections［J］．Med Princ Pract，2009，16(5)：344-347．

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备注/Memo

备注/Memo:
作者简介：张灵玲(1983-)，女，硕士，主管技师，从事临床基础检验和质量控制工作，Tel：13982230767，E-mail：lindaling610@163.com。 通讯作者：张朝明，主任技师，研究生导师，从事临床化学及实验室管理工作
更新日期/Last Update: 1900-01-01