[1]谢而付,黄珮珺,赵中建,等.HCMV感染婴儿尿液病毒载量与肝脏损伤指标的相关性分析[J].现代检验医学杂志,2016,31(01):25-27.[doi:10.3969/j.issn.1671-7414.2016.01.007]
　XIE Er-fu,HUANG Pei-jun,ZHAO Zhong-jian,et al.Correlation between Urine HCMV Virus Load and Liver Function Indications among HCMV-Infected Infants[J].Journal of Modern Laboratory Medicine,2016,31(01):25-27.[doi:10.3969/j.issn.1671-7414.2016.01.007]
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HCMV感染婴儿尿液病毒载量与肝脏损伤指标的相关性分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年01期
页码:
25-27
栏目:
论著
出版日期:
2016-01-25

文章信息/Info

Title:
Correlation between Urine HCMV Virus Load and Liver Function Indications among HCMV-Infected Infants
作者:
谢而付; 黄珮珺; 赵中建; 陈 丹; 张炳峰; 潘世扬
南京医科大学第一附属医院检验学部,南京 210029
Author(s):
XIE Er-fu; HUANG Pei-jun; ZHAO Zhong-jian; CHEN Dan; ZHANG Bing-feng; PAN Shi-yang
Department of Laboratory Medicine, the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China
关键词:
人巨细胞病毒;  人巨细胞病毒脱氧核糖核酸;  尿液;  肝脏损伤指标
分类号:
R373; R392.11
DOI:
10.3969/j.issn.1671-7414.2016.01.007
文献标志码:
A
摘要:
目的 定量检测人巨细胞病毒(HCMV)感染婴儿尿液中HCMV DNA含量,检测肝脏损伤指标,并比较尿液HCMV病毒载量与肝脏损伤指标的相关性。方法 选取HCMV感染的婴儿,收集其新鲜尿液,使用荧光定量聚合酶链式反应法(FQ-PCR)检测HCMV DNA,定量检测血清ALT,AST,ALP,GGT,T-Bil和D-Bil肝脏损伤指标,并进行阳性率统计; 将尿液HCMV DNA取对数后,分别与ALT,AST,ALP,GGT,T-Bil和D-Bil进行Spearman相关性分析。结果 444例HCMV感染婴儿尿液HCMV分布范围为<2.70～7.90; 血清ALT,AST,ALP,GGT,T-Bil和D-Bil的阳性率分别为24.8%,59.0%,95.7%,31.1%,16.7%和16.3%; 尿液HCMV DNA对数与GGT存在一定的相关性,相关系数为0.099(P<0.05),而与ALT,AST,ALP,T-Bil和D-Bil均不存在相关性。结论 HCMV感染婴儿肝损伤指标具有一定的阳性率,且尿液HCMV病毒载量与GGT具有一定的相关性,与其它指标无相关性。
Abstract:
Objective To quantifying the urine human cytomegalovirus(HCMV)DNA from the HCMV infection infants and its corresponding liverfunction indications,and investigate the relationship between their concentrations.Methods The urine samples were collected from HCMVinfection infants.HCMV DNA was measured by fluorescence quantitative polymerase chain reaction(FQ-PCR).Serum ALT,AST,ALP,GGT,T-Bil and D-Bil liver function indications were detected and the positive rate was analyzed,simultaneously.The correlation between the logarithm urine HCMV DNA(log HCMV DNA)concentration and ALT,AST,ALP,GGT,T-Bil and D-Bil were analyzed by Spearman correlation analysis.Results The distribution range ofurine log HCMV DNA in 444 HCMV infection infants was <2.70～7.90; the positive rate of serum ALT,AST,ALP,GGT,T-Bil and D-Bil were 24.8%,59.0%,95.7%,31.1%,16.7% and 16.3%,respectively.The urine log HCMV DNA was associated with GGT and the correlation coefficient was 0.099(P<0.05),but no associated with ALT,AST,ALP,T-Bil and D-Bil.Conclusion The positive rate of liver function indications will rise in HCMV infection infants,theurine log HCMV DNA was associated with GGT,but not associated with other liverfunction indications.

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备注/Memo

备注/Memo:
基金项目:江苏省实验诊断学重点实验室基金(XK201114); 国家自然科学基金(81101322); 江苏高校优势学科建设工程资助项目。 作者简介:谢而付(1978-),男,博士在读,副主任技师,主要从事临床免疫学研究与临床工作,E-mail:xieerfu791010@163.com。 通讯作者:黄珮珺,E-mail:hpj63@163.com。
更新日期/Last Update: 2016-01-20