[1]李晓晴,惠海英,骆志成.香叶醇、β-香茅醇和丁香酚抗念珠菌活性的体外研究[J].现代检验医学杂志,2016,31(02):87-89.[doi:10.3969/j.issn.1671-7414.2016.02.026]
　LI Xiao-qing,HUI Hai-ying,LUO Zhi-cheng.Study on Anticandidal Activities of Geraniol, β-Citronellol and Eugenol in Vitro[J].Journal of Modern Laboratory Medicine,2016,31(02):87-89.[doi:10.3969/j.issn.1671-7414.2016.02.026]
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香叶醇、β-香茅醇和丁香酚抗念珠菌活性的体外研究()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年02期
页码:
87-89
栏目:
论著
出版日期:
2016-06-01

文章信息/Info

Title:
Study on Anticandidal Activities of Geraniol, β-Citronellol and Eugenol in Vitro
作者:
李晓晴1; 惠海英1; 骆志成2
1.陕西省人民医院皮肤科,西安 710068; 2.兰州大学第二医院皮肤科,兰州 730030
Author(s):
LI Xiao-qing1; HUI Hai-ying1; LUO Zhi-cheng2
1.Department of Dermatology,Shaanxi Provincial People's Hospital,Xi'an 710068,China; 2.Department of Dermatology,the Second Hospital of Lanzhou University,Lanzhou 730030,China
关键词:
中药单体;  念珠菌;  微生物敏感性试验
分类号:
R379.4; R446.5
DOI:
10.3969/j.issn.1671-7414.2016.02.026
文献标志码:
A
摘要:
目的 探讨香叶醇、β-香茅醇和丁香酚3种中药单体体外抗念珠菌活性。方法 先采用纸片法药敏试验对3种中药单体抗念珠菌活性进行初筛实验,再参照CLSI-M27-A方案中的微量稀释法检测3种中药单体对61株临床分离致病念珠菌的最小抑菌浓度(MIC)。结果 3种中药单体对61株临床分离念珠菌均具有较强的抑菌活性,对念珠菌属的平均MIC分别为:香叶醇424.70±387.33 μg/ml,β-香茅醇411.70±419.05 μg/ml和丁香酚579.15±468.81 μg/ml。结论 香叶醇、β-香茅醇和丁香酚3种中药单体对临床常见条件致病性念珠菌均具有不同程度的抑制作用; CLSI M27-A方案中的酵母菌微量稀释法适合于抗真菌中药的筛选。
Abstract:
Objective To determine the anticandidal activities of three Chinese herbal monomers(Geraniol,β-Citronellol and Eugenol)invitro.Methods The anticandidal activities of the threecompounds were examined by disc diffusion method,then the minimum inhibitory concentration(MIC)was tested in 61 clinically isolated Candida strains by CLSI-M27-A microdilution method.Results All of testedCandida strains were susceptible to Geraniol,β-Citronellol and Eugenol,and their MICs were 424.70±387.33 μg/ml,411.70±419.05 μg/ml and 579.15±468.81 μg/ml,respectively.Conclusion Geraniol,β-Citronellol and Eugenol were of anticandidal activities in vitro.Microdilutionmethod from M27-A is be available for the susceptibility-testing of Candida toChinese herbs in vitro.

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备注/Memo

备注/Memo:
作者简介:李晓晴(1980-),女,硕士研究生,主治医师,研究方向:医学真菌病,E-mail:medlixq@126.com。
更新日期/Last Update: 2016-02-20