[1]包安裕.血清25-(OH)D水平在胃癌患者中的临床意义[J].现代检验医学杂志,2016,31(02):133-135,138.[doi:10.3969/j.issn.1671-7414.2016.02.040]
　BAO An-yu.Clinical Significance of Serum 25-Hydroxyvitamin D Level of Gastric Cancer Patients[J].Journal of Modern Laboratory Medicine,2016,31(02):133-135,138.[doi:10.3969/j.issn.1671-7414.2016.02.040]
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血清25-(OH)D水平在胃癌患者中的临床意义()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年02期
页码:
133-135,138
栏目:
检验与临床
出版日期:
2016-06-01

文章信息/Info

Title:
Clinical Significance of Serum 25-Hydroxyvitamin D Level of Gastric Cancer Patients
作者:
包安裕
武汉大学人民医院检验科,武汉 430060
Author(s):
BAO An-yu
Department of Clinical Laboratory, Renmin Hospital of Wuhan University,Wuhan 430060,China
关键词:
胃癌;  25-羟基维生素D
分类号:
R735.2; R730.43
DOI:
10.3969/j.issn.1671-7414.2016.02.040
文献标志码:
A
摘要:
目的 研究血清25-羟基维生素D[25-(OH)D]水平在胃癌患者中的临床意义,并且探讨血清25-(OH)D与胃癌进展的关系。方法 采用免疫电化学发光法检测胃癌患者和健康对照者的血清25-(OH)D浓度,进行统计学分析,比较胃癌患者和健康对照者的血清25-(OH)D浓度有无统计学差异,比较不同临床分期、组织分化程度、肿瘤大小、远行转移等指标下对应的胃癌患者血清25-(OH)D水平的差异有无统计学意义。结果 胃癌组血清25-(OH)D水平(10.12±5.78ng/ml)显著低于对照组(18.12±7.36 ng/ml)(t=8.51,P<0.001)。胃癌Ⅰ期的血清25-(OH)D水平显著高于胃癌Ⅲ期(P=0.01)和胃癌Ⅳ期(P=0.006)的水平。胃癌高分化组患者的血清25-(OH)D水平显著高于中分化、低分化和未分化组的水平(均P<0.001)。血清25-(OH)D水平与胃癌淋巴结转移、远行转移、肿瘤大小、肿瘤位置均无显著相关性(均P>0.05)。结论 胃癌患者25-(OH)D比健康对照者低; 胃癌的临床分期越晚,维生素D水平越低; 组织学分化程度越低,维生素D水平越低。
Abstract:
Objective To explore the significance of serum 25-hydroxyvitamin D[25-(OH)D] level and the risk of gastric cancer,and investigate the correlation between 25-(OH)D level and the clinic-pathologicalcharacteristics of patients with gastric cancer.Methods The immune-chemiluminescence method was used to measure the serum 25-(OH)D level in order to compare the difference of gastric cancer patients and healthy controls.The general features of patients with gastric cancer(such as age,gender,nationality,sampling season,smoking and drinking status)and clinic-pathological data(such as clinical stage,histological differentiation,lymph node metastasis,tumor size,tumor metastasis,tumor site)were collected.Explored therelationship between various clinic-pathological features and 25-(OH)D level in gastric cancer patients.Analysis of variance and t-test were used to compare the differences of 25-(OH)D level at various indexes such as clinical stage,differentiation degree,tumor size and metastasis.Results 25-(OH)D level was 10.12±5.78 ng/ml and 18.12±7.36 ng/ml in gastriccancer group and control group,respectively.Serum 25-(OH)D level of the gastric cancer group was significantly lower than that in the control group(t=8.51,P<0.001).There was a significant difference of serum 25-(OH)D in different clinical stages of gastric cancer patients(F=3.26,P=0.025).Serum 25-(OH)D level of Gastric cancer stage Ⅰpatients was significantly higher than that of stage Ⅲ(P=0.01)and stage IV(P=0.006).With the improvementof the tumor differentiation,serum 25-(OH)D levels showed an increasing trend.Serum 25-(OH)D level of high differentiated group was significantly higher than that of low differentiation,moderate differentiated and undifferentiated group(P<0.001).No significant relationship were found between serum 25-(OH)D level and lymph node metastasis,tumor metastasis,tumor size,and tumor site(P>0.05).Conclusion Serum 25-(OH)D level represented the vitamin D status of the body.This study elucidated the vitamin D level in patients with gastric cancer was lower than that in healthy controls.Low vitamin D level may be the prediction of high risk of gastric cancer.The later clinical stage,the lower vitamin D level.The poorer the histological differentiation degree,the lower level of vitamin D.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助,项目编号81502087。 作者简介:包安裕(1981-),男,博士,主治医师,研究方向为激素与肿瘤,E-mail:baoanyu2008@163.com。
更新日期/Last Update: 2016-02-20