[1]邓永超,唐喜春,杨 娟,等.平均血小板质量与降钙素原在儿童川崎病诊断中的应用价值[J].现代检验医学杂志,2016,31(05):144-146.[doi:10.3969/j.issn.1671-7414.2016.05.043]
 DENG Yong-chao,TANG Xi-chun,YANG Juan,et al.Clinical Value of Mean Platelet Mass and the Procalcitonin in Diagnosis of Kawasaki Disease[J].Journal of Modern Laboratory Medicine,2016,31(05):144-146.[doi:10.3969/j.issn.1671-7414.2016.05.043]
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平均血小板质量与降钙素原在儿童川崎病诊断中的应用价值()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第31卷
期数:
2016年05期
页码:
144-146
栏目:
检验与临床
出版日期:
2016-10-21

文章信息/Info

Title:
Clinical Value of Mean Platelet Mass and the Procalcitonin in Diagnosis of Kawasaki Disease
文章编号:
1671-7414(2016)05-144-03
作者:
邓永超唐喜春杨 娟黄彩芝莫丽亚
湖南省儿童医院检验科,长沙 410007
Author(s):
DENG Yong-chaoTANG Xi-chunYANG JuanHUANG Cai-zhiMO Li-ya
Department of Clinical Laboratory,Hunan Children's Hospital,Changsha 410007,China
关键词:
平均血小板质量 川崎病 儿童
分类号:
R55; R446.11
DOI:
10.3969/j.issn.1671-7414.2016.05.043
文献标志码:
A
摘要:
目的 探讨平均血小板质量(mean platelet mass,MPM)与降钙素原(procalcitonin,PCT)在儿童川崎病(kawasaki disease,KD)诊断中的应用价值。方法 分别测定117例急性期川崎病患儿的MPM与血小板计数(PLT)、平均血小板体积(MPV)、血小板体积分布宽度(PDW)以及降钙素原(PCT)的水平,且与126例正常对照组儿童进行比较,并同时比较各指标的阳性率及相关性。结果 ①川崎病儿童急性期MPM水平显著低于对照组,PLT,MPV及PCT水平显著高于对照组(P<0.05,α=0.05); 两组PDW水平比较差异无统计学意义(P>0.05,α=0.05)。②MPM阳性率明显高于其它指标(P<0.05,α=0.05)。结论 MPM对儿童川崎病诊断具有较好的应用价值,可作为一项实验室辅助诊断指标在临床推广。
Abstract:
Objective To investigate the clinical value of mean platelet mass(MPM)and the procalcitonin(PCT)in diagnosis of Kawasaki disease(KD).Methods A Total of 117 children with KD in the acute stage and 126 children of the control group were detected respectively andcompared each other.The indexes contain MPM,PLT,MPV,PDW and PCT.Meanwhile,the comparison of each index's positive rate and the linear correlation analysis of each index were conducted.Results ①The level of MPM of the KD group was significant lower than that of the control group,PLT,MPVand PCT significant higher than those(P<0.05,α=0.05).The differenceof PDW between the two groups was no statistical significance(P>0.05,α=0.05).②The positive rate of the MPM was significant higher than that of the other indexes(P<0.05,α=0.05).Conclusion The detection of MPM is helpful to the diagnosis of KD and can be used as an indicatorof KD clinically.

参考文献/References:

[1] 李晓惠.川崎病诊断与治疗新进展[J].中华实用儿科临床杂志,2013,28(1):9-13. Li XH.Advances in diagnosis and treatment of Ka-wasaki disease[J].Chinese Journal of Applied Clinical Pediatrics,2013,28(1):9-13.
[2] Ayusawa M,Snonobe T,Uemura S,et al.Revision of diagnostic guidelinesfor Kawasaki disease(the 5th revised edition)[J].Pediatr Int,2005,47(2):232-234.
[3] 胡淑玲,党小军,崔化龙,等.西安地区健康成人血小板参数的调查分析[J].现代检验医学杂志,2014,29(4):101-102. Hu SL,Dang XJ,Cui HL,et al.Investigation and a-nalysis of healthy adults'plate-let parameters in Xi'an[J].Journal of Modern Laboratory Medcine,2014,29(4):101-102,105.
[4] Jia S,Li C,Wang G,et al.The T helper type 17/regulatory T cell imbalance in patients with acute Kawasaki disease[J].Clin Exp Immunol,2010,162(1):131-137.
[5] 杨 波,朱义杰,罗 军,等.川崎病流行病学、病因和发病机制的新进展[J].临床儿科杂志,2014,32(2):189-192. Yang B,Zhu YJ,Luo J,et al.Advances in epidemiology,etiology andpathogenesis of Kawasaki disease[J].Journal of Clinical Pediatrics,2014,32(2):189-192.
[6] 朱美华,梁 敏,王志坚,等.1991~2001年与2002~2011年川崎病临床特点的异同[J].中华实用儿科临床杂志,2013,28(9):686-689. Zhu MH,Liang M,Wang ZJ,et al.Clinical similarities and differences in Kawasaki disease during 1991~2001 and 2002~2011 periods[J].Chinese Journal of Applied Clinical Pediatrics,2013,28(9):686-689.
[7] 张小平,李亚蕊.血清降钙素原水平在早期辅助诊断不完全川崎病中的价值[J].中国药物与临床,2013,13(11):1476-1477. Zhang XP,Li YR.The value of serum procalcitonin in the early auxiliary diagnosis of incomplete kawasaki disease[J]Chinese Remedies & Clinics,2013,13(11):1476-1477.
[8] 梁 深.川崎病患儿治疗前后血清hs-CRP,IL-6和PCT检测的临床意义[J].放射免疫学杂志,2012,25(6):639-640. Liang S.The clinical significance of the serum hs-CRP,IL-6 and PCT before and after treatment in children with kawasaki disease[J].Journal of Radioimmunology,2012,25(6):639-640.
[9] 刘 健,万 磊,冯云霞,等.四种风湿病患者血小板参数变化及外周血BTLA,Treg观察[J].中国免疫学杂志,2014,30(4):508-511. Liu J,Wan L,Feng YX,et al.Observation changes of platelet parameters and BTLA,Treg in four kinds of rheumatic diseases[J].Chinese Journal ofImmunology,2014,30(4):508-511.
[10] 高锦萍,胡 丹.动态观察血小板参数对川崎病的临床意义[J].医学理论与实践,2012,25(20):2538-2539. Gao JP,Hu D.The clinical significance of the dyna-mic observation of the platelet parameters to kawasaki disease[J].The Journal of Medical Theory and Practice,2012,25(20):2538-2539.
[11] 高艳霞,李 莉,李 毅,等.血小板参数在感染性休克患者中的变化[J].中华危重病急救医学,2014,26(1):28-32. Gao YX,Li L,Li Y,et al.Change of platelet para-meters in septic shock patients[J].Chinese Critical Care Medcine,2014,26(1):28-32.

备注/Memo

备注/Memo:

作者简介:邓永超(1979-),男,硕士,副主任技师,从事临床血液学检验和研究工作,Tel:13487580732,E-mail:dyc_mail2000@sina.com。
更新日期/Last Update: 2016-10-30