[1]杨 阳,吴 嘉,汪俊军.FIB和D-二聚体联合GRACE评分与急性冠脉综合征的风险预测[J].现代检验医学杂志,2017,32(01):99-102.[doi:10.3969/j.issn.1671-7414.2017.01.027]
　YANG Yang,WU jia,WANG Jun-jun.FIB and D-D with GRACE Risk Score to Predict the Risk of Acute Coronary Syndrome[J].Journal of Modern Laboratory Medicine,2017,32(01):99-102.[doi:10.3969/j.issn.1671-7414.2017.01.027]
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FIB和D-二聚体联合GRACE评分与急性冠脉综合征的风险预测()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第32卷
期数:
2017年01期
页码:
99-102
栏目:
论著
出版日期:
2017-01-25

文章信息/Info

Title:
FIB and D-D with GRACE Risk Score to Predict the Risk of Acute Coronary Syndrome
文章编号:
1671-7414(2017)01-099-04
作者:
杨 阳1; 2; 吴 嘉1; 汪俊军1
1.南京大学医学院附属金陵医院临床检验科,南京 210002;
2.金坛区人民医院检验科,江苏常州 213200
Author(s):
YANG Yang1; 2; WU jia1; WANG Jun-jun1
1.Department of Clinical Laboratory,Jinling Hospital Affiliated to School of Medical, Nanjing University,Nanjing 210002,China;
2.Department of Clinical Laboratory, People's Hospital of Jintan District,Jiangsu Changzhou 213200,China
关键词:
急性冠脉综合征;  纤维蛋白原;  D-二聚体;  全球急性冠状动脉事件注册评分
分类号:
R543.3; R446.112
DOI:
10.3969/j.issn.1671-7414.2017.01.027
文献标志码:
A
摘要:
目的 探讨纤维蛋白原(FIB)、D-二聚体(D-D)联合GRACE评分对急性冠脉综合征(ACS)患者风险预测。方法 分别检测90例ACS患者,23例健康体检者血浆FIB,D-D,GRACE评分及ACS患者冠状动脉病变支数,分析其相关性。结果 ACS患病组FIB,D-D和GRACE评分分别为2.77±0.79g/L,1.67±2.13 mg/L,147.19±32.50分,与对照组(2.77±0.13 g/L,0.21±0.08 mg/L,92.30±19.5分)比较显著增高,差异有统计学意义(t=6.256,6.465,10.317,P值均＜0.001); 血浆D-D,FIB含量在不同的危险分层比较,差异有统计学意义(F=18.475,9.426,P值均＜0.001); 相关性分析显示ACS患者血浆D-D(r=0.485,P＜0.000 1),FIB(r=0.357,P＜0.000 6)含量与GRACE评分呈正相关关系。结论 ACS患者血浆的FIB,D-D和GRACE评分均升高,FIB和D-D可作为ACS的风险预测因子,D-D的预测价值优于FIB。
Abstract:
Objective To investigate FIB and D-D with GRACE risk score to predict the risk of acute coronary syndrome(ACS)during hospitalization.Methods Plasma FIB,D-D and GRACE risk score were measured in 90 patients with ACS and 23 healthy controls,the number of coronary artery lesions of ACS patients also was obtained.Results The results of FIB,D-D levels and GRACE risk score in ACS group were 2.77±0.79 g/L,1.67±2.13 mg/L,147.19±32.50,respectively.Compared to controls,FIB,D-D and GRACE risk score in ACS group were significantly increased(t=6.256,6.465,10.317,all P＜0.001).There were significant differences in plasma D-D and FIB levels in different risk stratification(F=18.475,9.426,all P＜0.001).FIB(r=0.485,P＜0.000 1)and D-D(r=0.357,P＜0.000 6)levels were found positively related with GRACE risk score.Conclusion Pasma FIB,D-D levels and GRACE risk score were increasedin ACS group.FIB and D-D can be used as indicators to predict the risk stratification for ACS patients, and D-D was better than FIB.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金(81271904,81401742,81572073,81572074); 国家重大科学仪器设备开发专项(2012YQ03026109)。
作者简介:杨 阳(1986-),女,本科,初级技师,免疫检验与生化检验,E-mail:vipyyang@126.com。
通讯作者:汪俊军,男,硕士,主任技师,硕士研究生导师,E-mail:wangjj6@lonline.com。
更新日期/Last Update: 2017-01-20