[1]季红兵,唐芹芳,陈思聪,等.血清肿瘤标志物HE4对肺癌的诊断价值[J].现代检验医学杂志,2017,32(02):110-113.[doi:10.3969/j.issn.1671-7414.2017.02.030]
　JI Hong-bin,TANG Qin-fang,CHEN Si-cong,et al.Application of Serum HE4 in the Diagnosis of Lung Cancer[J].Journal of Modern Laboratory Medicine,2017,32(02):110-113.[doi:10.3969/j.issn.1671-7414.2017.02.030]
点击复制

血清肿瘤标志物HE4对肺癌的诊断价值()
分享到：

《现代检验医学杂志》[ISSN:/CN:]

卷:
第32卷
期数:
2017年02期
页码:
110-113
栏目:
论著
出版日期:
2017-03-25

文章信息/Info

Title:
Application of Serum HE4 in the Diagnosis of Lung Cancer
文章编号:
1671-7414(2017)02-110-04
作者:
季红兵; 唐芹芳; 陈思聪; 孙 静
东南大学医学院附属盐城医院检验科,江苏盐城 224001
Author(s):
JI Hong-bin; TANG Qin-fang; CHEN Si-cong; SUN Jing
Department of Clinical Laboratory,Affiliated Yancheng Hospital of Southeast University Medicine School,Jiangsu Yancheng 224000,China
关键词:
癌胚抗原;  细胞角蛋白片段21-1;  神经元特异性烯醇化酶;  人附睾蛋白4;  肺癌;  诊断
分类号:
R734.2; R730.43
DOI:
10.3969/j.issn.1671-7414.2017.02.030
文献标志码:
A
摘要:
目的 探讨血清肿瘤标志物人附睾蛋白4(human epididymis, HE4)对肺癌的诊断价值。方法 以80例肺癌患者为病例组,30例肺部良性疾病患者为良性对照组,30例健康人为健康对照组,检测所有研究对象的血清癌胚抗原(CEA),细胞角蛋白片段21-1(CYFRA21-1),神经元特异性烯醇化酶(NSE)和HE4水平。结果 病例组血清CEA,NSE,CYFRA21-1和HE4水平均高于良性对照组或健康对照组(P<0.05)。四种标志物诊断肺癌患者的受试者工作特征曲线(ROC曲线)下面积(AUC)分别为0.870,0.818,0.746和0.897。腺癌患者血清CEA和HE4,鳞癌患者血清CYFRA21-1,小细胞肺癌(SCLC)患者血清NSE水平较高(P<0.05)。血清CYFRA21-1(AUC=1.000),CEA(AUC=0.727)和HE4(AUC=0.622)水平检测对鳞癌诊断有价值(P<0.05),血清CEA(AUC=0.954)和HE4(AUC=0.944)水平检测对腺癌诊断有价值(P<0.05),检测血清NSE(AUC=0.876)水平对SCLC诊断有价值(P<0.05)。结论 肺癌患者血清HE4,CEA,NSE和CYFRA21-1等肿瘤标志物表达异常,患者血清HE4水平与肿瘤的病理类型及转移情况相关,血清HE4对腺癌有较高的敏感度,血清HE4水平检测可用于肺癌辅助诊断及病情评估。
Abstract:
Objective To investigate the diagnostic valuesof human epididymis(HE4)in lung cancer.Methods 80 patients with lung cancer were the experimental group,30 patients with benign pulmonary disease were the benign control group,and 30 healthy people were healthycontrol group.The levels of carcinoma embryonic antigen(CEA),cytokeratin protein fragment 21-1(CYFRA21-1),neuron specific enolase(NSE)and HE4 in serumwere detected.Results The levels of CEA,NSE,CYFRA21-1 and HE4 in lung cancer patients were higher than those in both the benign control group and the healthy control group(P<0.05).The areas(AUC)under thereceiver operating characteristic(ROC curve)were 0.870,0.818,0.746 and 0.897 for serum CEA,NSE,CYFRA21-1 and HE4 levels in diagnosis of lung cancer.The levels of CEA and HE4 were higher in patients with adenocarcinoma,the level of CYFRA21-1 was higher in patients with squamous cell carcinoma,the levelof NSE was higher in patients with small cell lung cancer(SCLC)(P<0.05).The detections of CYFRA21-1(AUC=1.000),CEA(AUC=0.727)and HE4(AUC=0.622)in serum are favorable for the diagnosis of squamous cell carcinoma,The detections of serum CEA(AUC=0.954)and HE4(AUC=0.944)levels are favorable forthe diagnosis of adenocarcinoma,and the detections of NSE(AUC=0.876)was favorable for the diagnosis of SCLC(P<0.05).Conclusion The levels of CEA,NSE,CYFRA21-1 and HE4 in serum were abnormal in patientswith lung cancer.The HE4 level in the patients was correlated with the pathological types and the metastasis of lung cancer.The detection of serum HE4 couldbe used in the diagnosis and evaluation of lung cancer.

参考文献/References:

[1] Jiang Y,Wang C,Lu B,et al.Expression level of serum human epididymis 4 and its prognostic significance in human non-small cell lung cancer[J].Int J Clin Exp Med,2014,7(12):5568-5572.
[2] Guo YD,Wang JH,Lu H,et al.The human epididymis protein 4 acts as a prognostic factor and promotes progression of gastric cancer[J].Tumour Biol,2015,36(4):2457-2464.
[3] Jr NB,Bhattoa HP,Steiber Z,et al.Serum human epididymis protein(HE4)as a tumor marker in men with lung cancer[J]. Clin Chem Lab Med,2014,52(11):1639-1648.
[4] Iwahori K,Suzuki H,Kishi Y,et al.Serum HE4 as a diagnostic and prognostic marker for lung cancer[J].Tumour Biol,2012,33(4):1141-1149.
[5] Siegel R,Ma J,Zou Z,et al.Cancer statistics,2014[J].CA Cancer J Clin,2014,64(1):9-29.
[6] 中华人民共和国卫生部.2013年中国卫生统计年鉴[M].北京:中国协和医科大学出版社,2013. Ministry of Health of the People's Republic of China.Yearbook ofChinese Health Statistics,2013[M].Beijing:Chinese Peking Union Medical College Press,2013.
[7] 中华人民共和国卫生部.2014年中国卫生统计年鉴[M].北京:中国协和医科大学出版社,2014. Ministry of Health of the People's Republic of China.Yearbook of Chinese Health Statistics,2014[M].Beijing:Chinese Peking Union Medical College Press,2014.
[8] 孙 炜,田小平,庄惠芹,等.肺癌患者血清HE4表达临床意义的初步探讨[J].现代检验医学杂志,2013,28(6):50-51,54. Sun W,Tian XP,Zhuang HQ,et al.Preliminary study of the clinicalsignificance of serum human epididymis protein HE4 in patients with lung cancer[J].Journal of Modern Laboratory Medicine,2013,28(6):50-51,54.
[9] Liu GL,Liu X,Lu XB,et al.miR-148b functions as a tumor suppressor innon-small cell lung cancer by targeting carcinoembryonic antigen(CEA)[J].Int J Clin Exp Med,2014,7(8):1990-1999.
[10] Qin HF,Qu LL,Liu H,et al.Serum CEA level cha-nge and its significance before and after gefitinib therapy on patients with advanced non-small cell lung cancer[J].Asian Pac J Cancer Prev,2013,14(7):4205-4208.
[11] Cui C,Sun X,Zhang J,et al.The value of serum Cyfra21-1 as a biomarker in the diagnosis of patients with non-small cell lung cancer:a meta-analysis[J].J Cancer Res Ther,2014,10(Suppl):C131-134.
[12] Szturmowicz M, Rudziński P, Kacprzak A,et al.Prognostic value of serum C-reactive protein(CRP)and cytokeratin 19 fragments(Cyfra 21-1)but notcarcinoembryonic antigen(CEA)in surgically treated patients with non-small cell lung cancer[J].Pneumonol Alergol Pol,2014,82(5):422-429.
[13] Jung M,Kim SH,Lee YJ,et al.Prognostic and predictive value of CEA and CYFRA 21-1 levels in advanced non-small cell lung cancer patients treated with gefitinib or erlotinib[J].Exp Ther Med,2011,2(4):685-693.
[14] Yan HJ,Tan Y,Gu W.Neuron specific enolase and prognosis of non-smallcell lung cancer:a systematic review and meta-analysis[J].J BUON,2014,19(1):153-156.
[15] Alm El-Din MA,Farouk G,Nagy H,et al.Cytokeratin-19 fragments,nucleosomes and neuron-specific enolase as early measures of chemotherapy responsein non-small cell lung cancer[J].Int J Biol Markers,2012,27(2):e139-146.
[16] Macedo AC,da Rosa MI,Lumertz S,et al.Accuracy of serum human epididymis protein 4 in ovarian cancer diagnosis:a systematic review and meta-analysis[J].Int J Gynecol Cancer,2014,24(7):1222-1231.
[17] Ferraro S,Panteghini M.Is serum human epididymis protein 4 ready for prime time[J].Ann Clin Biochem,2014,51(Pt 2):128-136.
[18] Wang X,Fan Y,Wang J,et al.Evaluating the expression and diagnostic value of human epididymis protein 4(HE4)in small cell lung cancer[J].TumourBiol,2014,35(7):6847-6853.

相似文献/References:

[1]朱 晶,翟海军.血清CEA,Ferritin和血浆D-D对肺癌化疗的效果评估[J].现代检验医学杂志,2015,30(04):144.[doi:10.3969/j.issn.1671-7414.2015.04.044]
　ZHU Jing,ZHAI Hai-jun.Evaluation on the Effect of Serum CEA,Ferritin and Plasma D-D on Lung Cancer Chemotherapy[J].Journal of Modern Laboratory Medicine,2015,30(02):144.[doi:10.3969/j.issn.1671-7414.2015.04.044]
[2]詹颉,常宁宁,李小侠,等.CEA，AFP，CA125，CA199和CA72-4联合检测在鉴别卵巢良恶性疾病中的应用价值[J].现代检验医学杂志,2015,30(05):50.[doi:10.3969/j.issn.1671-7414.2015.05.015]
　ZHAN Jie,CHANG Ning-ning,LI Xiao-xia,et al.Clinical Value of Combined Detection of CEA，AFP，CA125，CA199 and CA72-4 in the Identification of Ovarian Benign and Malignant Disease[J].Journal of Modern Laboratory Medicine,2015,30(02):50.[doi:10.3969/j.issn.1671-7414.2015.05.015]
[3]王芳胜,熊敦勇,寇辉,等.血清AFP，CEA，CA-199与TAP在肝癌诊断中的应用价值[J].现代检验医学杂志,2015,30(05):148.[doi:10.3969/j.issn.1671-7414.2015.05.047]
　WANG Fang-sheng,XIONG Dun-yong,KOU Hui,et al.Application Value of Serum AFP，CEA，CA-199 and TAP in the Diagnosis of Hepatocellular Carcinoma[J].Journal of Modern Laboratory Medicine,2015,30(02):148.[doi:10.3969/j.issn.1671-7414.2015.05.047]
[4]张 华a,李小侠a,刘 婧a,等.胸腔积液中CEA,FDP和DD检测对良恶性胸腔积液鉴别的意义[J].现代检验医学杂志,2017,32(06):122.[doi:10.3969/j.issn.1671-7414.2017.06.001]
　ZHANG Huaa,LI Xiao-xiaa,LIU Jinga,et al.Diagnosis Value of CEA,FDP and DD in the Pleural Effusion Specimens for Benign and Malignant Pleural Effusion[J].Journal of Modern Laboratory Medicine,2017,32(02):122.[doi:10.3969/j.issn.1671-7414.2017.06.001]
[5]陈绪阳a,吉茂礼b,刘雪花b,等.外周血MPV,PDW与血清CEA联合检测对胃癌和胃溃疡的鉴别诊断作用[J].现代检验医学杂志,2019,34(01):107.[doi:10.3969/j.issn.1671-7414.2019.01.028]
　CHEN Xu-yanga,JI Mao-lib,LIU Xue-huab,et al.Differential Diagnosis of Gastric Cancer and Gastric Ulcer by Joint Detection of Peripheral Blood MPV，PDW and Serum[J].Journal of Modern Laboratory Medicine,2019,34(02):107.[doi:10.3969/j.issn.1671-7414.2019.01.028]
[6]刘　涛,杨　燕,刘　博,等.联合检测胸腹腔积液sCD44V6,CEA,CYFRA21-1,CA199，NSE,CA125 对良恶性疾病鉴别诊断价值研究[J].现代检验医学杂志,2020,35(02):53.[doi:10.3969/j.issn.1671-7414.2020.02.016]
　LIU Tao,YANG Yan,LIU Bo,et al.Value of Combined Detection of sCD44V6, CEA,CYFRA21-1,CA199,NSEand CA125 in the Differential Diagnosis of Benign and MalignantPleural and Peritoneal Effusion[J].Journal of Modern Laboratory Medicine,2020,35(02):53.[doi:10.3969/j.issn.1671-7414.2020.02.016]

备注/Memo

备注/Memo:

作者简介:季红兵(1972-),男,本科,副主任技师,主要从事免疫学检验,Tel:13921872299,E-mail: jhb72@163.com。
更新日期/Last Update: 2017-04-10