[1]林金端a,刘红伟a,张欣宁b,等.Mybl2在不同病变程度宫颈组织中的表达[J].现代检验医学杂志,2017,32(02):141-142，145.[doi:10.3969/j.issn.1671-7414.2017.02.039]
　LIN Jin-duana,LIU Hong-weia,ZHANG Xin-ningb,et al.Expression Level and Clinical Significance of Mybl2 in Cervical Tissues[J].Journal of Modern Laboratory Medicine,2017,32(02):141-142，145.[doi:10.3969/j.issn.1671-7414.2017.02.039]
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Mybl2在不同病变程度宫颈组织中的表达()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第32卷
期数:
2017年02期
页码:
141-142，145
栏目:
研究简报·实验技术
出版日期:
2017-03-25

文章信息/Info

Title:
Expression Level and Clinical Significance of Mybl2 in Cervical Tissues
文章编号:
1671-7414(2017)02-141-03
作者:
林金端a; 刘红伟a; 张欣宁b; 李介华a
广州医科大学附属第六医院a.检验科; b.妇产科,广东清远 511500
Author(s):
LIN Jin-duana; LIU Hong-weia; ZHANG Xin-ningb; LI Jie-huaa
a.Department of Laboratory Medicine; b.Department of Gynecology and Obstetrics,the Sixth Affiliated Hospital of Guangzhou Medical University,Guangdong Qingyuan,511500,China
关键词:
Mybl2;  宫颈癌;  酶联免疫吸附试验;  宫颈上皮内瘤变
分类号:
R737.33; R730.43
DOI:
10.3969/j.issn.1671-7414.2017.02.039
文献标志码:
A
摘要:
目的 探讨Mybl2在不同病变程度宫颈组织中的表达情况及差异。方法 收集宫颈组织74例,采用ELISA法检测组织中的Mybl2蛋白表达水平,分析Mybl2蛋白浓度与临床病理资料的关系。结果 宫颈组织中的Mybl2表达量随着宫颈病变程度的增加而增加,组间差异有统计学意义(F=27.39,P<0.05); 同一病变组中,高龄组的Mybl2表达量高于非高龄组,但差异无统计学意义(P均>0.05)。结论 随着宫颈病变程度的增加,Mybl2的表达量也增加,Mybl2在宫颈癌组织中高表达,可能与宫颈癌的发生发展有关。
Abstract:
Objective To study the expression and clinicalsignificance of Mybl2 in Cervical tissues.Methods 74 cases of cervical tissues were obtained from the department of obstetrics and gynecology.The expression level of Mybl2 was detected by Elisa method,and the relationship with clinical pathology was analyzed.Results Elisa results showed that the expression of Mybl2 was significant among inflammation,CINI,CINII,CINIII and ICC groups(F=27.39,P<0.05).The expression level of Mybl2 was higher in the older group that the younger one which were in the same clinical pathology degree,but it was not was significant(P>0.05).Conclusion The expression levels of Mybl2 were related with the pathological changes of cervix.Disturb expression level of Mybl2 maybe induce the development of cervical cancer.

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备注/Memo

备注/Memo:
基金项目:清远市科技计划项目(编号:2013B042)。
作者简介:林金端(1983-),女,在读博士,副主任检验师,主要研究领域为临床检验诊断(分子生物学方向),Tel:0763-3113890,E-mail:linjinduan4@163.com。
通讯作者:李介华,主任技师,E-mail:13828501998@126.com。
更新日期/Last Update: 2017-04-10