[1]顾熙东a,章晓鹰a,孙学华b.非酒精性脂肪肝患者ALT升高相关危险因素分析[J].现代检验医学杂志,2017,32(03):140-143.[doi:10.3969/j.issn.1671-7414.2017.03.039]
　GU Xi-Donga,ZHANG Xiao-yinga,SUN Xue-huab.Analysis of the Related Risk Factors for Elevated ALT Level in Patients with Non-Alcoholic Fatty Liver Diseases[J].Journal of Modern Laboratory Medicine,2017,32(03):140-143.[doi:10.3969/j.issn.1671-7414.2017.03.039]
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非酒精性脂肪肝患者ALT升高相关危险因素分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第32卷
期数:
2017年03期
页码:
140-143
栏目:
检验与临床
出版日期:
2017-05-25

文章信息/Info

Title:
Analysis of the Related Risk Factors for Elevated ALT Level in Patients with Non-Alcoholic Fatty Liver Diseases
文章编号:
1671- 7414(2017)03-140-04
作者:
顾熙东a; 章晓鹰a; 孙学华b
上海中医药大学附 属曙光医院a.检验科；
b.肝炎科，上海 201203
Author(s):
GU Xi-Donga; ZHANG Xiao-yinga; SUN Xue-huab
a.Department of Clinical Laboratory；
b.Department of H epatology，Shanghai University of Traditional Chinese Medical Affiliated Shuguang Hospital，Shanghai 2012 03，China
关键词:
非酒精性脂肪肝; 谷氨酸氨基转移酶; 尿酸; 游离脂肪酸
分类号:
R575.5；R446.112
DOI:
10.3969/j.issn.1671-7414.2017.03.039
文献标志码:
A
摘要:
目的 分析非酒精性脂肪肝(non-alcoholic fatty liver diseases，NAFLD)ALT升高相关危险因素。方法 选择非酒精性脂肪 肝ALT升高患者56例(男性25例，女性31例)与ALT正常患者153例(男性64例，女性89例)，正 常人群160例(男性80例，女性80例)。应用速率法测定ALT，酶法测定总胆固醇(TC)、三酰甘 油 (TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、尿酸(UA)，比浊 法测定游离脂肪酸(FFA)。将ALT与TC，TG，LDL-C，HDL-C，UA，FFA进行spearman相关分 析，并利用二元Logistic回归分析ALT升高的危险因素。结果 尽管 男性与女性非酒精性脂肪肝患者(包括ALT升高与ALT正常组)TC，TG，LDL-C，UA，FFA水平 明显高于正常组，HDL-C明显低于正常组，差异具有统计学意义。但是，Logistic回归分析 与Spearman相关分析显示只有UA与FFA为ALT升高的危险因素，并与ALT呈显著的正相关。男 性UA，FFA异常分别可使ALT升高危险性增加3.96倍(95CI%=1.40～11.22，P=0.010) 与3.27倍(95%CI=1.14～9.40，P=0.028)，二者与ALT相关系数分别为0.40(P= 0.000)，0.29(P=0.006)；女性UA，FFA升高，ALT升高Exp(B)值则分别为4.49 (95C I%=1.79～11.28，P=0.001)与3.17 (95CI%=1.25～8.04，P=0.015)，相关 系数分别为0.34(P=0.000)，0.27(P=0.003)。结论 非 酒精性脂肪肝ALT升高并非与血脂异常相关而是与UA，FFA水平相关，二者可以作为预测肝损 程度的候选指标。
Abstract:
Objective To analysis the risk factors for elev ated ALT level in patients with Non-alcoholic fatty liver diseases(NAFLD)． Met hod Fifty-six (male 25，female 31) NAFLD patients with elevated ALT and 153 NAF LD patients (male 64，female 89) with normal ALT and 160 (male 80，female 80) he alth subjects were selected．ALT was detected by rate assay，total cholesterol ( TC)，triglycerides (TG)，low-density lipoprotein cholesterols (LDL-C)，high-d ensity cholesterol (HDL-C) and uric acid (UA) were detected by enzymatic method ．Free fatty acid (FFA) was detected by immunoturbidimetry assay．Spearman corre lation was used to analysis the relation between ALT and TC，TG，LDL-C，HDL-C ，UA and FFA．Logistic regression was used to analyses the risk factor for eleva ted ALT level．Results TC，TG，LDL-C，UA and FFA levels were significantly higher in NAFLD group (including normal ALT group and elevate d ALT group) than those in health group no matter male and female，HDL-C was si gnificantly lower in these two groups when compared to control group，but binary logistic regression and spearman analysis showed that only UA and FFA were the risk factors for elevated ALT level and significantly positively correlated with ALT level，abnormal UA and FFA for male were associated with 3.96-fold(95CI%= 1.40～11.22，P=0.010) and 3.27-fold(95%CI=1.14～9.40，P=0.028) of increased risk of elevated ALT level respectinely，correlation coefficient we re 0.40(P=0.000)，0.29(P=0.006)，Meanwhile Exp(B) of elevated ALT l evel for female with abnormal UA，FFA were 4.49 (95CI%=1.79～11.28，P=0. 001)　and 3.17 (95CI%=1.25～8.04，P=0.015)，correlation coefficient were 0.34(P=0.000)，0.27(P=0.003)．Conclusion Ele vated ALT level was not associated with dyslipidemias，but related to UA and FFA ．They can be used as candidate markers for predicting severity of liver damage ．

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备注/Memo

备注/Memo:

作者简介：顾熙东(1985-)，男，大学本科，检验师，从事临床医学检验，E-mail：2102164288@qq .com。
通讯作者：章晓鹰，主任技师，E-mail：zhangxy_10@126.com
更新日期/Last Update: 2017-06-25