[1]陈宇翔,洪煜婧,赵 枰,等.心脏瓣膜置换术后检测sEPCR的临床价值分析[J].现代检验医学杂志,2017,32(03):146-148.[doi:10.3969/j.issn.1671-7414.2017.03.041]
 CHEN Yu-xiang,HONG Yu-jin,ZHAO Ping,et al.Clinical Analysis of Human Soluble Endothelial Protein C Receptor after Heart Valve Replacement[J].Journal of Modern Laboratory Medicine,2017,32(03):146-148.[doi:10.3969/j.issn.1671-7414.2017.03.041]
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心脏瓣膜置换术后检测sEPCR的临床价值分析()
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《现代检验医学杂志》[ISSN:/CN:]

卷:
第32卷
期数:
2017年03期
页码:
146-148
栏目:
检验与临床
出版日期:
2017-05-25

文章信息/Info

Title:
Clinical Analysis of Human Soluble Endothelial Protein C Receptor after Heart Valve Replacement
文章编号:
1671-7 414(2017)03-146-03
作者:
陈宇翔1洪煜婧2赵 枰1朱易华1
1 .南通大学第二附属医院检验科,江苏南通 226001;
2.南通大学公共卫生学院预防医学141班,江苏南通 226019
Author(s):
CHEN Yu-xiang1HONG Yu-jin2ZHAO Ping1ZHU Y i-hua1
1.Department of Clinical Laboratory,the Second Affiliated Hosp ital of Nantong University,Jiangsu Nantong 226001,China;
2.Preventive Medicine Class 14 1, School of Public Health,Nantong University,Jiangsu Nantong 226019,China
关键词:
心脏瓣膜置换术可溶性内皮细胞蛋白c受体血栓栓塞国际 标准化比值
分类号:
R654.2;R392.11
DOI:
10.3969/j.issn.1671-7414.2017.03.041
文献标志码:
A
摘要:
目的 分析血浆可溶性内皮细胞蛋白C受体(sEPCR)对心脏瓣 膜置换术后抗凝治疗及检测的临床价值。方法 收集2005年1月~201 6年6月于南通大学第二附属医院开展心脏瓣膜置换术的78例患者为研究对象,将其分为栓塞 组(38例)和对照组(40例),两组均于术前1天、术后监测INR稳定后检测INR和sEPCR,两组间 INR和sEPCR值的比较分析采用t检验。结果 两组间术前1天及术 后INR(术前:1.24±0.32 vs 1.23±0.19;术后:1.86±0.95 vs 1.93±0.97)的 差异均无统计学意义(术前:t=0.17,P=0.868;术后:t=0.32,P=0.748);sEPCR 术前(34.91±9.14 μg/L vs 35.56±10.22 μg/L)差异均无统计学意义(t=0.30,P =0.768)。栓塞组栓塞时sEPCR(101.33±27.15 μg/L)显著高于对照组(41.67±11.8 2 μg/L)(t=12.69,P=0.000)。结论 栓塞组sEPCR显著高于 对照组,对其进行检测可以有效地指导临床开展抗凝治疗。
Abstract:
Objective To investigate the clinical value of human soluble endothelial protein C receptor (sEPCR) after heart valve replaceme nt.Methods 78 cases of patients with heart valve replace ment in the Second Affiliated Hospital of Nantong University from January 2005 t o June 2016 were selected as the research objects,who were divided into embolic group and control group,38 cases in embolic group and 40 cases in control grou p,the index of two groups 1 d preoperative,while dynamic monitoring internatio nal standardization ratio (INR) and embolism,were detected,of which INR and sE PCR were examined.The INR and sEPCR oftwo groups was compared with t test.〖WT 5”HZ〗Results The INR and sEPCR of two groups 1 d preoperative had no significant difference (1.24±0.32 vs 1.23±0.19,34.91±9.14 μg/L vs 35.56±10.22 μg/L;t=0.17,P=0.868;t=0.30,P=0.768,respectively).T he average value of dynamic monitoring INR in control group had no significant d ifference when compared with the results of embolism (1.86±0.95 vs 1.93±0. 97,t=0.32,P=0.748).But the sEPCR had significant difference (101.33±2 7.15 μg/L vs 41.67±11.82 μg/L,t=12.69,P=0.000).Conclus ion The important indexes of sEPCR could effectively guide the antic oagulant treatment,especially those who with the sEPCR value too high,the embo lic threatening should be paid attention to.

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备注/Memo

备注/Memo:

作者简介:陈宇翔(1973-),男,大学本科,主管技师,主要从事免疫学检验工作,Tel :18912252296,E-mail:ntyycyx@163.com。
更新日期/Last Update: 2017-06-25